Scientists find new treatment targets for retinoblastoma
Scientists find new treatment targets for retinoblastomaRetinoblastoma is a rare cancer that arises from the retina of the eye. It usually develops in early childhood, typically before the age of 5. Most cases of retinoblastoma are caused by mutations in the RB1 gene. RB1 is ...
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Study provides novel way to fight against Helicobacter pylori
Study provides novel way to fight against Helicobacter pyloriHelicobacter pylori (Hp) is a bacterium that specifically colonizes the human gastric epithelium. It is found in approximately two-thirds of the world's population. Many people acquire Hp infection in the early years of ...
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Research offers insight into pathogenicity of fungus in plants
Research offers insight into pathogenicity of fungus in plantsA study from Centre for Plant Biotechnology and Genomics sheds light on the versatility of a fungal protein called Alt a 1. Alt a 1 is a strongly allergenic protein found in the spores of certain Alternaria fungus. Al...
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Scientists identify a new RNA-binding protein in bacterial pathogens
Scientists identify a new RNA-binding protein in bacterial pathogensA study, led by Professor Jörg Vogel from the University of Würzburg, has identified the function of the protein ProQ. Described in the journal PNAS, the study shows that ProQ binds to 98 regulatory RNAs of the bacteri...
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Obesity: one main risk factor of liver cancer
Obesity: one main risk factor of liver cancerThe prevalence rates of obesity and an obesity-related disease -- type 2 diabetes mellitus -- are increasing in many regions of the world. Moreover, rates of liver cancer have steadily climbed. To find whether there is a...
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Eating soy protein during childhood prevents bone loss during adulthood
Eating soy protein during childhood prevents bone loss during adulthoodAccording to a paper published online before print Oct. 12 in The FASEB Journal, a diet rich in soy protein during early life could prevent bone loss during adulthood. The study, carried out by scientists at Arkansas Chi...
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Experimental drug effectively kills glioblastoma cells by blocking cholesterol
Experimental drug effectively kills glioblastoma cells by blocking cholesterolA study appearing in the latest issue of Cancer Cell shows that glioblastoma (GBM) cells import large amounts of cholesterol in order to survive, and an experimental drug can target this process. GBM is the most preva...
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Potential drug target for obesity and diabetes identified
Potential drug target for obesity and diabetes identifiedThe Scripps Research Institute researchers have found a potent target for the treatment of obesity and type 2 diabetes. The study, led by Anutosh Chakraborty, appears in The Journal of Clinical Investigation. Obesity,...
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Running helps repair the damaged brain of mice
Running helps repair the damaged brain of miceIt's well known that exercise has great benefits for one's health. Some scientists believe that exercise can improve cognitive function and slow down the development of neurodegenerative diseases. A recent study appea...
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Scientists find an approach to enhance efficacy of FLT3 inhibitors against AML
Scientists find an approach to enhance efficacy of FLT3 inhibitors against AMLFLT3 inhibitors have shown the potential to combat acute myeloid leukemia (AML) in clinical trials. These drugs, however, can not control the disorder for a long time when used alone. Now, a research team from the Univer...
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Clues to the connection between metabolic and anxiety-related disorders
Clues to the connection between metabolic and anxiety-related disordersWe know that the mind affects the body and vice versa. Earlier studies have reported that psychological trauma has an impact on gene activity. It is believed that metabolic and anxiety-related disorders share some biolog...
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A clinical trial shows JAK inhibitors prevent hair loss
A clinical trial shows JAK inhibitors prevent hair lossJAK inhibitors may be used to treat patients with alopecia areata, according to a new study carried out by scientists at Columbia University Medical Center (CUMC). The study, appearing in the Journal of Clinical Investig...
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Novel pathway implicated in depression
Novel pathway implicated in depressionDepression is incredibly common -- 10 to 20 percent of people will develop this condition during their lifetime. Unfortunately, not all patients respond well to existing antidepressant drugs. A lot of people do not benef...
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New approach to prevent drug resistance to a frontline cancer drug
New approach to prevent drug resistance to a frontline cancer drugRecently, a research team from the University of Bradford and Queen's University Belfast has found an approach to solve the problem of drug resistance in some types of cancers. The study, led by Prof. Mohamed El-Tanani, ...
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Bacterial amyloid protein enhances alpha-synuclein deposition in rat
Bacterial amyloid protein enhances alpha-synuclein deposition in ratA paper appearing in Scientific Reports shows that a bacterial amyloid protein may cause the misfolding of brain proteins, leading to inflammation. The discovery indicates that there might be a link between gut bacteria ...
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Scientists identify the culprit of brain cell death during stroke
Scientists identify the culprit of brain cell death during strokeA research team led by scientists at UT Southwestern Medical Center has found that a protein, called macrophage migration inhibitory factor (MIF), leads to brain cell death during stroke. The study, reported in the journ...
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Blocking LAG3 protein may inhibit the progress of Parkinson's disease
Blocking LAG3 protein may inhibit the progress of Parkinson's diseaseA recent study published in Science shows that an immunotherapy for cancer might also inhibit the progress of the second most common neurodegenerative disorder: Parkinson's disease (PD). The study was conducted by invest...
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Protective protein Ang-1 increases survival rate of mice with malaria
Protective protein Ang-1 increases survival rate of mice with malariaMalaria is a deadly disease caused by the Plasmodium parasite, which can be transmitted to human by the bites of infected mosquitoes. While efforts to control malaria-carrying mosquitoes are decreasing infection rates, m...
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Mosquito saliva protein inhibits the spread of Dengue virus
Mosquito saliva protein inhibits the spread of Dengue virusIn the search for ways to decrease the transmission of Dengue virus (DENV), a research team from Central Michigan University College of Medicine finds that a protein in the saliva of mosquitoes inhibits DENV infection. ...
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Study reveals mechanism by which a natural compound suppresses inflammation
Study reveals mechanism by which a natural compound suppresses inflammationA natural compound called resveratrol can suppress inflammation caused by nontypeable Haemophilus influenzae (NTHi), a type of bacterium responsible for many respiratory diseases. This is the result of a new study from s...
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Non-coding RNA is involved in cancer
Non-coding RNA is involved in cancerIt has been found that more than 98% of the genetic sequence inside each of our cells does not encode proteins. But it does not mean that the non-coding sequence has no function. Recently, researchers at Cold Spring H...
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Scientists reveal the role of oligodendrocytes in ALS
Scientists reveal the role of oligodendrocytes in ALSAmyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease, is a rapidly progressive neurological disease, which is marked by gradual degradation and eventual death of neuronal axons. ALS can cause muscle...
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Calorie restriction prevents abdominal aortic aneurysm
Calorie restriction prevents abdominal aortic aneurysmA research team led by scientists at the Chinese Academy of Medical Sciences and Peking Union Medical College has found that a calorie-restricted diet protected mice from developing abdominal aortic aneurysm (AAA), a lif...
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A gene involved in circadian rhythm is associated with metastasis of breast cancer, study finds
A gene involved in circadian rhythm is associated with metastasis of breast cancer, study findsAccording to an article published Sep. 22 in PLOS Genetics, the National Cancer Institute (NCI) scientists have identified a gene that is associated with the metastasis of estrogen receptor-negative breast cancer. The ge...
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Study reveals a mechanism by which bacteria trigger urinary tract infections
Study reveals a mechanism by which bacteria trigger urinary tract infectionsA urinary tract infection (UTI) is an infection that can occur in any part of the urinary system: the bladder, urethra, ureters and kidneys. It is the second most common type of infection in the body. UTIs can be caused ...
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Anti-CD44 antibody has therapeutic effect on AML
Anti-CD44 antibody has therapeutic effect on AMLAcute myeloid leukemia (AML) is a blood cancer in which immature blood cells fail to mature and therefore cause harmful effects. Recently, researchers at King Abdullah University of Science and Technology (KAUST) have fo...
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New compound prevents growth of fungus responsible for aspergillosis
New compound prevents growth of fungus responsible for aspergillosisAspergillus fumigatus is a species of fungus that causes a range of diseases in human beings, especially in those with an immunodeficiency. It is one of the most prevalent of the airborne fungi. Now, in the journal ACS C...
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Investigational vaccine shows promise in protecting against Zika
Investigational vaccine shows promise in protecting against ZikaZika virus has been linked with congenital disease, and the incidence of Zika infection has exploded in the Americas in 2015. A vaccine that would protect pregnant women and fetuses from Zika infection is in urgent need....
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Scientists reveal how an existing drug kills TB
Scientists reveal how an existing drug kills TBThe Francis Crick Institute investigators say that they have found a novel target for the treatment of tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) bacteria. They have discovered th...
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Research shows a drug prevents non-alcoholic fatty liver disease
Research shows a drug prevents non-alcoholic fatty liver diseaseAs its name suggests, non-alcoholic fatty liver disease (NAFLD) is a medical condition that occurs when fat builds up in the liver due to causes other than excessive alcohol use. NAFLD is becoming more and more common be...
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Novel treatment strategy for inflammatory bowel disease
Novel treatment strategy for inflammatory bowel diseaseInflammatory bowel disease (IBD) is a broad term that describes inflammation of the colon and small intestine. Crohn's disease and ulcerative colitis are the most common types of IBD. It's estimated that 5 million people...
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Cancer research opens the possibility of targeting an enzyme critical for lipid synthesis
Cancer research opens the possibility of targeting an enzyme critical for lipid synthesisA research team led by the Salk Institute has developed a method to target fat synthesis in cancer cells, and therefore block cancer growth. The method, described in Nature Medicine, represents a new weapon to fight canc...
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Scientists use microRNAs to prevent the metastasis of breast cancer
Scientists use microRNAs to prevent the metastasis of breast cancerA new MIT research shows that a novel gene therapy, which uses microRNAs to regulate gene expression, may help prevent the metastasis and invasion of breast cancer cells. The finding is important because metastasis is th...
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How protective antibodies prevent norovirus from infecting cells?
How protective antibodies prevent norovirus from infecting cells?Published in the Proceedings of the National Academy of Sciences, a new study from Vanderbilt University Medical Center and Baylor College of Medicine shows how human antibodies prevent noroviruses from entering cells, a...
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A strain of E. coli hampers kidney infection treatment
A strain of E. coli hampers kidney infection treatmentNew research from the University of California, Los Angeles (UCLA) reveals that antibiotic-resistant bacteria make it harder to treat pyelonephritis, a severe and sudden kidney infection. A variety of viruses and bact...
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Researchers find a compound that forces cells to differentiate in AML mice
Researchers find a compound that forces cells to differentiate in AML miceA compound stops the progression of acute myeloid leukemia (AML) in mice, according to a study carried out by scientists at the Harvard Stem Cell Institute and  Massachusetts General Hospital. The study, which is re...
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Decreasing SET protein may reawaken tumor suppressor p53
Decreasing SET protein may reawaken tumor suppressor p53Researchers at Columbia University have found that decreasing the levels of the SET protein can reawaken the tumor suppressor protein p53. The study, which has been reported in Nature, suggests a way to combat cancer. ...
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Scientists find a novel target for the intervention of obesity
Scientists find a novel target for the intervention of obesityObesity is a fast-growing problem in many regions of the world, especially in developed countries. Obesity is a chronic, medical condition in which too much body fat has accumulated. A certain amount of body fat is neces...
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Zika virus seems to cause brain injury in pigtail macaques
Zika virus seems to cause brain injury in pigtail macaquesA study published online 12 September in Nature Medicine reports that Zika virus can cause brain damage in a species of monkey called pigtail macaque. This may provide a model for therapeutic evaluation. Although 80 p...
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Researchers identify genes associated with blood pressure
Researchers identify genes associated with blood pressureA large-scale study, co-led by researchers at the Queen Mary University of London and the University of Cambridge, has revealed 31 new gene regions that are associated with hypertension and blood pressure. The researcher...
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Aggressive treatment may prolong the lifespan of people with type 2 diabetes
Aggressive treatment may prolong the lifespan of people with type 2 diabetesType 2 diabetes is the most common form of diabetes, accounting for more than 90 percent of all diabetes cases. People with the disorder often have no symptoms at first. But if a person with type 2 diabetes does not keep...
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Mice experiments show zinc finger protein suppresses mutant Huntington's gene
Mice experiments show zinc finger protein suppresses mutant Huntington's geneA new study, led by Imperial College London investigators, has shown that a special protein known as zinc finger may be used to slow the progression of Huntington's disease, a chronic, inherited brain disorder affec...
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Scientists find genetic links to intellectual disability
Scientists find genetic links to intellectual disabilityA collaborative research team has made a breakthrough in the search for new treatments for intellectual disability (ID), a common neurodevelopmental disorder that affects about 1 to 3 percent of the population. The resea...
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New clues about brain changes in autism
New clues about brain changes in autismAutism spectrum disorder (ASD) refers to a group of complex neurodevelopment disorders that cause significant social, communication and behavioral challenges. Now, a new study reports on a potential drug target that incr...
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Bacterial enzyme may be a treatment option for celiac disease
Bacterial enzyme may be a treatment option for celiac diseaseCeliac disease is an immune reaction to eating gluten, a protein found in wheat, barley, rye and other grains. This protein triggers an immune response in patients' small intestine, which harms the lining of the small in...
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Study shows a new drug may be effective in treating melanoma
Study shows a new drug may be effective in treating melanomaAccording to a study published in the scientific journal EBioMedicine, an experimental drug called pevonedistat does not kill cancer cells directly, as originally intended, but blocks proteins that cancer cells rely on t...
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Giving up smoking can benefit people at high risk of lung cancer
Giving up smoking can benefit people at high risk of lung cancerThere is no doubt that smoking is harmful to your health. Smoking is a leading cause of cancer and of death from cancer. Lots of chemicals in tobacco products and secondhand smoke can damage your DNA. It has been found t...
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Study reveals second protective mechanism against HIV/TB co-infection
Study reveals second protective mechanism against HIV/TB co-infectionMonkeys co-infected with TB and a simian strain of HIV have a second line of immune defense against TB. This is the discovery of a new research from Tulane University. Mycobacterium tuberculosis (Mtb) is a bacterium t...
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c-Rel protein may delay development of type 1 diabetes, study finds
c-Rel protein may delay development of type 1 diabetes, study findsType 1 diabetes, an autoimmune disease, makes up 5 percent of all cases of diabetes and usually affects children and young adults. It happens when T cells, white blood cells that normally protect the body from illnesses,...
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Antibiotic exposure may increase the risk of childhood food allergy
Antibiotic exposure may increase the risk of childhood food allergyA study from the University of South Carolina shows that exposure to antibiotics in the first year of life may elevate the risk of food allergy. The study appears in Allergy, Asthma & Clinical Immunology. The rese...
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