Why does drinking alcohol increase your cancer risk?
Why does drinking alcohol increase your cancer risk?Drinking too much alcohol is detrimental to your health. Nearly everyone knows it. It's estimated that 3.6 % of all cancer cases worldwide are attributable to alcohol drinking. But the molecular mechanism of how alcohol ...
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Inhibition of a host enzyme suppresses Ebola infection
Inhibition of a host enzyme suppresses Ebola infectionThe recent outbreaks of Ebola virus have attracted the world's attention. The virus can cause life-threatening illness in people, but at present, no FDA-approved vaccine or medicine is available for it. Thus, it is imper...
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Engineering antibodies in vivo fights autoimmune disorders
Engineering antibodies in vivo fights autoimmune disordersUnder normal conditions, the immune system protects the body from foreign invaders, such as viruses, bacteria, fungi, and parasites. The immune system also helps to fight cancer by detecting and destroying abnormal cells...
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Unique mechanism of cancer metastasis identified
Unique mechanism of cancer metastasis identifiedDescribed in the Proceedings of the National Academy of Sciences, a study titled "RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases" has shown that the RSK2 protein may drive the m...
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What causes postpartum depression?
What causes postpartum depression?The arrival of a new baby is an exciting and happy thing for a family. But some new mothers experience extreme sadness, hopelessness, anxiety, excessive crying, sleep problems, physical pains, eating too little or too mu...
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Reactivation of FoxO3 represents a way to treat pulmonary fibrosis
Reactivation of FoxO3 represents a way to treat pulmonary fibrosisPulmonary fibrosis, a medical condition in which the lungs get scarred over time, can cause severe breathing problems. The pathogenesis of pulmonary fibrosis has not been fully understood, hindering the development of mo...
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The drug hydralazine may have therapeutic effect against aging-related disorders, study finds
The drug hydralazine may have therapeutic effect against aging-related disorders, study findsHydralazine, a drug used to treat high blood pressure and heart failure, successfully extends healthy lifespan (about 25%) in the roundworms C. elegans by activating the NRF2/SKN-1 signaling pathway. This is...
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Different people may eat different diets in order to prevent colorectal cancer
Different people may eat different diets in order to prevent colorectal cancerA team of researchers from Centro Nacional de Investigaciones Oncológicas (CNIO) and Hospital Universitario Ramón y Cajal in Spain has found that what you eat may influence the risk of colorectal cancer. The discovery ...
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Things that you need to know about the flu
Things that you need to know about the fluThe flu is an extremely common illness. Regardless of age, all people may be affected by the flu. Generally, the flu is more common in winter, although it can be detected all the year round. That's why experts recommend ...
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New clues to Aβ pathology in Alzheimer's disease
New clues to Aβ pathology in Alzheimer's diseaseAlzheimer's disease (AD), the leading cause of dementia in old people, is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brains of patients. A lot of research has been carried out on ...
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Tacrolimus shows therapeutic effects in a rat model of Parkinson's Disease
Tacrolimus shows therapeutic effects in a rat model of Parkinson's DiseaseScientists are one step closer to understanding the pathogenesis of Parkinson's Disease (PD), a neurological disorder whose cause is complex and remains unknown. PD affects a person's movement, balance, and ...
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What causes Crohn's disease?
What causes Crohn's disease?Crohn's disease is an inflammatory disease of the digestive tract. The disease was first described by a gastroenterologist called Burrill Bernard Crohn in the 1930s. That's why the disease is so named. Despite decades of...
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IFN-β may have anti-tumor effects in triple-negative breast cancer
IFN-β may have anti-tumor effects in triple-negative breast cancerBreast cancer is one of the most common causes of cancer death in women. According to the World Cancer Research Fund International, there were about 1.7 million new cases of breast cancer worldwide in 2012. Triple-negati...
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Discovery of genetic signature would improve diagnosis of dementia with Lewy bodies
Discovery of genetic signature would improve diagnosis of dementia with Lewy bodiesA genome-wide association study (GWAS) has identified a special genetic signature in dementia with Lewy bodies, a discovery that would have significant implications for the diagnosis and treatment of the devastating diso...
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Inhibition of FKBP51 represents a novel approach to treating diabetes
Inhibition of FKBP51 represents a novel approach to treating diabetesA study, carried out by researchers from the Max Planck Institute of Psychiatry, Helmholtz Zentrum München, Ludwig Maximilians University, and Institute of Organic Chemistry and Biochemistry in Germany, has suggested th...
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Lactic acid bacteria help combat influenza
Lactic acid bacteria help combat influenzaThe flu, or influenza, is an illness caused by an influenza virus. Influenza viruses that infect humans include three types, A, B, and C. Of these virus types, influenza A type is the most common type that causes illness...
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New compound prevents Zika and dengue infections
New compound prevents Zika and dengue infectionsYou may have heard of the dangerous Zika virus (ZIKV). The recent outbreak of ZIKV in Brazil has raised the concern of the whole world. Certain countries in the Americas and Asia are the most heavily affected. Besides, Z...
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Accumulation of urea in the brain plays a role in Huntington's disease
Accumulation of urea in the brain plays a role in Huntington's diseaseAs people age, the risk of dementia increases. Exactly, dementia is not a specific disease. It's a general term for a decline in mental ability that can be caused by many different brain diseases. Typical symptoms of dem...
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Promising gene therapy for a deadly inherited disorder
Promising gene therapy for a deadly inherited disorderSevere combined immunodeficiency (SCID) is a group of inherited diseases that are already present at birth. SCID is caused by a defect in one of several possible genes. SCID-associated genetic mutations disturb the devel...
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An anti-cancer drug treats Huntington's disease in mice
An anti-cancer drug treats Huntington's disease in miceAs well age, we tend to develop age-related diseases and health conditions. One group of diseases strongly linked to age are neurodegenerative diseases, which are progressive, debilitating and largely untreatable conditi...
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Activation of Hedgehog signaling prevents obesity induced by high-fat diet
Activation of Hedgehog signaling prevents obesity induced by high-fat dietThere is no doubt that obesity has become a major health issue that requires personal and societal changes. Considerable literature shows that obesity causes metabolic abnormalities and increases the risk of a variety of...
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Thyroid hormone, a potential therapy for lung fibrosis
Thyroid hormone, a potential therapy for lung fibrosisPulmonary fibrosis is a life-threatening disease that usually affects old people, particularly those with a history of smoking. In pulmonary fibrosis, scars are formed in the lung, impairing lung function. People with pu...
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Study identifies a protein critical for HIV infection
Study identifies a protein critical for HIV infectionHIV infection rates have increased in many countries in the latest several decades, according to recent reports. The precise mechanisms by which the virus infects host cells and evades the host's immune attacks have not ...
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Combinations of epigenetic therapy drugs may improve treatment of lung cancer
Combinations of epigenetic therapy drugs may improve treatment of lung cancerStephen Baylin, who is a professor of oncology and medicine from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, and his team recently found that combinations of epigenetic therapy drugs potentiated anti-...
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Hepatic PTPR-γ may be a target for treatment of type 2 diabetes
Hepatic PTPR-γ may be a target for treatment of type 2 diabetesObesity, which is defined as a body mass index of 30 or greater, has become a major global health challenge. The worldwide prevalence of obesity has increased significantly in recent several decades. A wide range of heal...
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Reason behind gender differences in asthma
Reason behind gender differences in asthmaAsthma Asthma is a common inflammatory disease of the airways in the lungs. It often begins in childhood but can affect people of all ages. So far, no cure exists and current treatments are aimed to relieve...
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Efferocytosis may contribute to bone metastasis in prostate cancer, study shows
Efferocytosis may contribute to bone metastasis in prostate cancer, study showsOne of the mechanisms that the body uses to remove dying/dead cells is called efferocytosis ("to carry to the grave"). In efferocytosis, dying/dead cells are engulfed by phagocytic cells such as macrophages and dendritic...
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Protein found in a helminth parasite induces regulatory T cells
Protein found in a helminth parasite induces regulatory T cellsA multidisciplinary group of immunologists, parasitologists, and molecular biologists, headed by Prof. Rick Maizels of the University of Glasgow, has identified a parasite protein that mimics the cytokine TGF-β in human...
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Findings of a new study would facilitate development of TB vaccines
Findings of a new study would facilitate development of TB vaccinesA research, carried out by several institutions in the United Kingdom and Australia, has provided new clues to how the body responds to the bacteria that cause tuberculosis (TB). The discovery will facilitate the develop...
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Potential way to prevent against a big killer in humans -- heart disease
Potential way to prevent against a big killer in humans -- heart diseaseHeart disease is one of the leading causes of death worldwide. A common form of heart disease, known as coronary artery disease (CAD), is triggered by plaque buildup in the walls of coronary arteries -- the blood vessels...
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Key signaling pathway identified in the regeneration of blood vessels
Key signaling pathway identified in the regeneration of blood vesselsDiscoveries of a new research published in the journal Nature Communications would have important implications for regenerative medicine. The research, carried out by Fangfei Li, Junko Sawada and Masanobu Komatsu from Sa...
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Physical exercise improves memory and boosts beneficial factors that decline with age
Physical exercise improves memory and boosts beneficial factors that decline with ageLife is movement, which means that physical exercise is important for keeping health. People who lead a sedentary life are more likely to fall ill than those who live an active life. The benefits of regular physical acti...
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A modification of Snail1 drives cancer metastasis
A modification of Snail1 drives cancer metastasisCancer is a research hotspot in the field of medicine. Overcoming cancer will extend the lifespan of humans and reduce the amount of early death. But there is still a very long way to go to achieve this goal. More than 1...
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Use of lansoprazole is associated with a reduced rate of TB
Use of lansoprazole is associated with a reduced rate of TBTuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis (Mtb) that often affects the lungs. Despite considerable progress in the prevention, screening, diagnosis, and treatment of the disease, T...
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New insight into the pathophysiology of multiple sclerosis
New insight into the pathophysiology of multiple sclerosisAffecting millions of people globally, multiple sclerosis is still a disease with no cure. This is in part because the pathophysiology of the disease has not been completely elucidated. Now, researchers at C...
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ITGB3 could be targeted to treat autism spectrum disorder
ITGB3 could be targeted to treat autism spectrum disorderInvestigators from Vanderbilt University have made a breakthrough in understanding the genetic and molecular basis of autism spectrum disorder (ASD). Their main finding is that a variation in the integrin beta3 (ITGB3) g...
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Study provides insight into the relationship between vitamin D and rheumatoid arthritis
Study provides insight into the relationship between vitamin D and rheumatoid arthritisVitamin D is an important nutrient. Getting enough vitamin D is critical for our bone health. People who eat a diet deficient in vitamin D and who have inadequate sun exposure are likely to have weak bones. Health expert...
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Structural analysis sheds light on how antibodies recognize a critical protein in malaria parasite
Structural analysis sheds light on how antibodies recognize a critical protein in malaria parasiteMalaria, one of the leading cause of death on our planet, is a preventable illness caused by parasites called plasmodia. To develop effective vaccines, a deep understanding of the parasite-host interactions is essential....
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Some women may be naturally protected against Zika virus
Some women may be naturally protected against Zika virusPregnant mothers and their unborn babies are prone to viral infections. Zika virus is one such threat that has received widespread concern in recent years. In most cases (about 80%), Zika infection is asymptomatic, meani...
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Novel approach to combating triple-negative breast cancer
Novel approach to combating triple-negative breast cancerTriple-negative breast cancer, an aggressive subtype of breast cancer, makes up about 15% of all breast cancer cases. A triple-negative breast cancer diagnosis means that the tumor is clinically negative for expression o...
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Cell therapy based on blood stem cells may provide a cure for type 1 diabetes
Cell therapy based on blood stem cells may provide a cure for type 1 diabetes Scientists have developed a cell therapy with the potential to cure type 1 diabetes (T1D) in mice. Because the cell therapy is based on autotransplantation, it will cause no serious side effects. Described i...
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A double-stranded RNA successfully prevents liver cancer in mice
A double-stranded RNA successfully prevents liver cancer in miceScientists from the University of California in the USA and Fudan University in China have found a preventive strategy for liver cancer, one of the main killers in humans. The discovery is significant, especially for tho...
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Resistin and related molecules may provide new therapies for sepsis
Resistin and related molecules may provide new therapies for sepsisResearchers from the University of California and the University of Pennsylvania have demonstrated in mice that a human protein provides protection against a life-threatening condition known as "sepsis". Sep...
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Lack of the protein ankyrin-B contributes to obesity
Lack of the protein ankyrin-B contributes to obesityWhat is the chief culprit of obesity? There are various possible answers, such as a high fat, high cholesterol diet, and a sedentary lifestyle. However, things are not so simple. In fact, some individuals are more prone ...
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New therapeutic target for treating AML
New therapeutic target for treating AMLAcute myeloid leukemia (AML) is a fast-growing cancer of the myeloid line of blood cells. Most AML patients who achieve complete remission after initial treatment will eventually relapse. That's what makes the disease so...
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Therapeutics that enhance SORLA might combat Alzheimer's disease
Therapeutics that enhance SORLA might combat Alzheimer's diseaseAlzheimer's disease (AD) is the most common irreversible cause of dementia, accounting for 50-70% of all dementia cases. Of the various genetic risk factors linked to AD, apolipoprotein E (ApoE) is the most prevalent one...
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Structure analysis of viral protein provides clues to how RVFV infects a cell
Structure analysis of viral protein provides clues to how RVFV infects a cellViral infections are a serious threat to public health and livestock husbandry. Some viruses can be easily and efficiently transmitted to humans and/or animals by mosquitos. A recent study will help develop novel weapons...
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Eating mushrooms makes you younger?
Eating mushrooms makes you younger?We are told that eating mushrooms is good for our health. Now, a new study provides evidence to this. Researchers, including Michael Kalaras, John Richie, Ana Calcagnotto, and Robert Beelman from the Pennsyl...
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Promising approach to suppress cancer growth by restricting glucose consumption
Promising approach to suppress cancer growth by restricting glucose consumptionScientists from the University of Colorado Anschutz Medical Campus (CU Anschutz) have found an approach to suppress cancer growth by restricting glucose consumption. Oxygen and nutrients like glucose are del...
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Manipulation of RNA splicing causes old cells to become young
Manipulation of RNA splicing causes old cells to become youngA group composed of scientists from the University of Exeter, the University of Brighton, and the University of Oxford, has shown that manipulation of splicing factors -- proteins involved in the removal of introns from ...
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