Study provides potential therapies for an inherited form of muscular dystrophy
Study provides potential therapies for an inherited form of muscular dystrophyBy screening existing compounds and experimental drugs, a team of researchers from Fred Hutchinson Cancer Research Center, Saint Louis University, the University of Rochester Medical Center, and Leiden University Medical...
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MicroRNA could modulate the development of nicotine dependence
MicroRNA could modulate the development of nicotine dependenceA new research has unveiled a previously unrecognized role for microRNA in nicotine dependence. The research would help understand why it's so difficult for people to stop smoking. A paper describing the res...
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Possible approach discovered for treating fragile X Syndrome
Possible approach discovered for treating fragile X SyndromeThe chromatin binding protein, Brd4, could be a drug target for a common form of inherited intellectual disability, according to a study published in the 17 August 2017 issue of the journal Cell. The study w...
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New study offers a potential way to overcome cancer resistance to treatment
New study offers a potential way to overcome cancer resistance to treatmentResearchers from the University of California San Francisco (UCSF) have shown that the enzyme GPX4 could be targeted to prevent acquired drug resistance. The discovery would improve cancer treatment in the future. ...
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New research will improve diagnosis and treatment of a rare form of kidney disease
New research will improve diagnosis and treatment of a rare form of kidney diseaseSeveral researchers at the Departments of Pathology and Genome Sciences of the University of Washington have identified a putative autoantigen in an uncommon kidney disease. Fibrillary glomerulonephritis (GN) is a con...
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Study sheds light on human immunity against mouth fungus
Study sheds light on human immunity against mouth fungusA new study "Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin," which is published in Science Immunology last week, sheds light on how the immune sy...
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More powerful vaccines for the flu developed
More powerful vaccines for the flu developedTwo papers appearing in the Journal of Virology demonstrate the effectiveness of a flu vaccine candidate in animals. The research was carried out by scientists from the University of Georgia (UGA) and Sanofi-Pasteur. ...
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Study suggests fibrinogen as a therapeutic target for myelin-related disorders
Study suggests fibrinogen as a therapeutic target for myelin-related disordersA study, carried out by researchers from the USA, Germany, and Australia, opens up a new avenue for treatment of neurological disorders like multiple sclerosis (MS). Lead researcher of the study is Dr. Kater...
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Gut bacteria influence response to the anti-cancer drug irinotecan
Gut bacteria influence response to the anti-cancer drug irinotecanIrinotecan, a first-line chemotherapy agent for colon cancer, can cause a wide spectrum of side effects, ranging from mild to severe. Irinotecan has been studied extensively in clinical trials, and it's estimated that 40...
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Lipids produced by gut bacteria contribute to atherosclerosis
Lipids produced by gut bacteria contribute to atherosclerosisAccording to the World Health Organization, ischaemic heart disease and stroke were responsible for a combined 15 million deaths in 2015, making them the commonest killers worldwide. Heart disease and stroke have been li...
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Klotho gene therapy holds promise for suppressing aging-associated cognitive decline
Klotho gene therapy holds promise for suppressing aging-associated cognitive declineInvestigators have developed a gene therapy with the potential to reduce aging-associated cognitive decline. The study would have implications for neurodegenerative diseases like Alzheimer's disease and multiple sclerosi...
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Study sheds light on aging-induced immunodeficiency
Study sheds light on aging-induced immunodeficiencyThe decline of immune function and the increase of systemic inflammation have been seen in the process of aging. But the precise mechanisms underlying these alterations remain unclear. Now, scientists from t...
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Research reveals a mechanism of acquired resistance to immunotherapy in lung cancer
Research reveals a mechanism of acquired resistance to immunotherapy in lung cancerA multidisciplinary team has identified genetic alterations that occur during immunotherapy and underlie treatment resistance in lung cancer. The study, titled "Impaired HLA Class I Antigen Processing and Pr...
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Scientists develop a candidate vaccine for HIV
Scientists develop a candidate vaccine for HIVA study, carried out by the University of Maryland in collaboration with Duke University, has demonstrated in rabbits that a synthetic glycopeptide (or called protein-sugar) could be a potential vaccine against HIV. Find...
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New animal model facilitates research on genetic hearing loss
New animal model facilitates research on genetic hearing lossScientists have developed a gene therapy for an extremely rare genetic disorder, known as USH3. The gene therapy constrains hearing loss in a new USH3 mouse model. USH3, a subtype of Usher syndrome (USH), is an autoso...
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Why does dietary restriction increase lifespan?
Why does dietary restriction increase lifespan?A study in the worm C. elegans suggests that regulating mitochondrial function by dietary restriction or genetic method can increase lifespan. The findings, available in this month's online edition of the journal Cell Me...
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Potential way to combat acute myeloid leukemia
Potential way to combat acute myeloid leukemiaNumerous genetic alterations have been identified in tumor samples from individuals with acute myeloid leukemia (AML). But the translation of these discoveries into clinical practice has remained a big challenge. This is...
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High IMP2 linked to poor prognosis in gallbladder cancer
High IMP2 linked to poor prognosis in gallbladder cancerGallbladder cancer is a relatively uncommon but highly lethal malignancy, which forms in the gallbladder -- a small organ that plays a role in digestion by storing bile made by the liver. The median survival of patients ...
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The fallopian tubes may be the origin site of ovarian cancer
The fallopian tubes may be the origin site of ovarian cancerOvarian cancer is one of the commonest causes of cancer-related mortality among women. The overall survival rate of ovarian cancer has remained low, although numerous efforts have been undertaken to design novel diagnost...
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R-Spo1 protein rebalances gut microbiota
R-Spo1 protein rebalances gut microbiotaIn the human gut, there is a complex community of microorganisms, collectively known as the gut microbiota. It is well-established that the gut microbiota has a huge impact on people body health. The balance of the gut m...
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Genetic study reveals genetic variants that would improve breast cancer screening
Genetic study reveals genetic variants that would improve breast cancer screeningA large-scale genetic study has identified 65 new genetic variants that increase the risk of breast cancer. Published online 23 Oct. 2017 in Nature, the study (Association analysis identifies 65 new breast cancer risk lo...
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Persistent activation of T cells perturbs neurotransmitter production in the brain
Persistent activation of T cells perturbs neurotransmitter production in the brainT cells, a subset of white blood cells, are of key importance to the body's immune response to infection and disease. Although it's known that activated T cells reorganize their metabolism to perform their function, the ...
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Oral bacteria can worsen bowel disease
Oral bacteria can worsen bowel diseaseA team composed of researchers from Japan, the USA, Israel, Egypt, and Singapore has made a breakthrough in discerning the cause of bowel disease. Described in the journal Science last week, their experiments indicate th...
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New tool will accelerate research on protein aggregation-relevant diseases
New tool will accelerate research on protein aggregation-relevant diseasesProtein aggregation, an abnormal deposition of proteins, has been found in a wide variety of disorders, particularly neurodegenerative diseases. In addition to neurodegenerative diseases, some other diseases like type 2 ...
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Targeting p53 through modulation of USP7 is a potential therapeutic strategy for cancer
Targeting p53 through modulation of USP7 is a potential therapeutic strategy for cancerp53 is a well-studied tumor suppressor gene. Because of its near universal alteration in cancer, p53 has long been identified as a therapeutic target for cancer. However, extensive research suggested that p53 is extremel...
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Animal experiments prove the efficacy of an anti-obesity therapeutic
Animal experiments prove the efficacy of an anti-obesity therapeuticThere is a worldwide concern of the epidemic of obesity. Obesity has been connected with a wide range of health problems. Therefore, a lot of pharmaceutical companies and research institutions are trying to seek effectiv...
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Study sheds light on how neutralizing antibodies prevent EBV from entering host cells
Study sheds light on how neutralizing antibodies prevent EBV from entering host cellsResearchers report that they have found a new clue to how EBV enters and infect the host cell. The finding would guide the development of therapies and vaccines for the common virus. Researchers participatin...
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A Fer/FerT inhibitor shows anti-cancer activity in vitro and in vivo
A Fer/FerT inhibitor shows anti-cancer activity in vitro and in vivoA team of researchers headed by Professor Uri Nir at Bar-Ilan University has developed a compound that inhibits enzymes critical for the survival of cancer cells. The compound has anti-cancer activity both in vitro and i...
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Novel tumor-specific target for colorectal cancer
Novel tumor-specific target for colorectal cancerScientists have identified a tumor-specific therapeutic target for colorectal cancers with mutations in the APC gene. Mutations in APC play a role in the vast majority of colorectal cancer cases. The APC gen...
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Study reveals an important neurological role of p75 protein
Study reveals an important neurological role of p75 proteinOur bodies' ability to feel touch, pressure, pain, temperature, position, and movement is dependent on a population of neurons, known as sensory neurons. But relatively little is known about the molecular mechanisms unde...
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ERG protects against liver disease
ERG protects against liver diseaseA team composed of researchers from Imperial College London and the University of Birmingham has demonstrated a protective role of the endothelial transcription factor ETS-related gene (ERG) in the liver. De...
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Lack of CLOCK triggers epilepsy, study suggests
Lack of CLOCK triggers epilepsy, study suggestsPublished in the October 11 issue of the journal Neuron, a study reveals that loss of a protein called CLOCK leads to abnormalities in brain circuits that trigger epilepsy. The study is led by Dr. Judy Liu a...
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Dual role of the androgen receptor in kidney cancer metastasis
Dual role of the androgen receptor in kidney cancer metastasisResearchers have identified a dual role of the androgen receptor (AR) in the metastasis of clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer. ccRCC is a gender-biased tumor. Men ...
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Worm study provides insight into aging
Worm study provides insight into agingThe Kruppel-like transcription factors (KLFs), a family of transcriptional factors, regulate autophagy and lifespan in the worm C. elegans, according to a study published online last week in the journal Nature Communicat...
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Research reveals a critical role of PRMT1 in antibody response
Research reveals a critical role of PRMT1 in antibody responseA new study has demonstrated a critical role of the enzyme PRMT1 in the activation and differentiation of B cells, the cells that produce antibodies to clear infections. The work was conducted by researchers...
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Multinational team identifies genetic variants associated with congenital heart disease
Multinational team identifies genetic variants associated with congenital heart diseaseCHD, short for congenital heart disease, is the most common type of birth defect, affecting 1 out of every 100 live births. The symptoms of CHD vary considerably. Some people display no symptoms. But for many people, the...
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Study identifies MKK6 as a therapeutic target for obesity
Study identifies MKK6 as a therapeutic target for obesityObesity is an increasingly serious problem in many countries in the world. There are an estimated 2.2 billion people being overweight or obese. So, scientists have been trying for years to uncover the secrets of obesity ...
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ALK inhibitor may treat ALK-negative cancers?
ALK inhibitor may treat ALK-negative cancers?Targeted therapy is a newer type of medical treatment for cancer. It blocks cancer cell growth by targeting specific molecules needed for cancer development and progression. Since targeted therapy can more precisely iden...
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Newly discovered mechanism of p53-mediated tumor suppression
Newly discovered mechanism of p53-mediated tumor suppressionp53 acts as a tumor suppressor, which is well-known in the field of cancer research. However, the mechanisms of p53-mediated tumor suppression have not been completely characterized. A new study (A p53 Super...
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Alzheimer's disease research finds TREM2 deficiency mitigates brain damage induced by tau pathology
Alzheimer's disease research finds TREM2 deficiency mitigates brain damage induced by tau pathologyResearchers studying Alzheimer's disease have a new insight into the roles of the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2). Their findings have important implications in the development ...
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Newly identified compound induces apoptosis in AML cells
Newly identified compound induces apoptosis in AML cellsScientists from Albert Einstein College of Medicine and Dana-Farber Cancer Institute find a compound that induces apoptosis -- a form of programmed cell death -- in acute myeloid leukemia (AML) cells. Notabl...
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UCLA study finds a novel combination treatment for glioblastoma
UCLA study finds a novel combination treatment for glioblastomaA team of scientists from David Geffen UCLA School of Medicine, Dana-Farber Cancer Institute, Roche Innovation Center, and the University of California San Diego have found a new treatment combination that would improve ...
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Why do defective viral genomes contribute to persistent infection?
Why do defective viral genomes contribute to persistent infection?Some viruses often cause acute infections, such as RSV, measles, and Ebola. But sometimes, these viruses trigger persistent infections following acute infections. Why this occurs remains largely unknown. Now...
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Study sheds light on the repair of a type of DNA damage
Study sheds light on the repair of a type of DNA damageA group of researchers from the USA and Spain has identified a protein involved in the repair of a type of DNA damage, called DNA-protein crosslinks (DPCs). The discovery provides clues to the repair pathway of DPCs. ...
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Cell-based therapy shows promise in ameliorating renal anemia
Cell-based therapy shows promise in ameliorating renal anemiaResearchers in Japan have developed a cell-based therapy for renal anemia, a common complication of chronic kidney disease. The cell-based therapy worked well in mice. The paper, "Human pluripotent stem cell-derived e...
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CRISPR-Cas9 technique helps identify drug targets for KRAS-mutated cancer
CRISPR-Cas9 technique helps identify drug targets for KRAS-mutated cancerA study, funded in part by the National Institutes of Health and led by the University of California San Diego School of Medicine, has identified genes affecting the growth of KRAS-mutated colorectal cancer cell lines in...
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Researchers identify an attractive target for a deadly form of ovarian cancer
Researchers identify an attractive target for a deadly form of ovarian cancerEpithelial ovarian cancer (EOC), the most common type of ovarian cancer, is extremely hard to treat because of its high tumor heterogeneity. More than 70% of the patients respond to initial treatment, but most of them wi...
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Neuroserpin protects against glaucoma, study suggests
Neuroserpin protects against glaucoma, study suggestsAustralian researchers have made progress in understanding the mechanism of glaucoma, a common eye disease that can lead to permanent vision loss. Published online 16 August 2017 in the journal Scientific Reports, the st...
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Genetic mutations reduce the efficacy of an anti-cancer drug
Genetic mutations reduce the efficacy of an anti-cancer drugAzacitidine (AZA) is an anti-cancer drug that is approved by the US FDA for the treatment of myelodysplastic syndrome (MDS). Sometimes, it is also used to treat acute myeloid leukemia (AML). So far, the factors that affe...
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Study deepens understanding of a dangerous parasite
Study deepens understanding of a dangerous parasiteSchistosoma haematobium (S. haematobium) is a parasite that is originally distributed in Africa and the Middle East. It triggers urogenital schistosomiasis, a debilitating disease affecting as many as 112 million people....
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