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Autophagy protein 5 is a protein in humans that is encoded by ATG5 gene. Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
The following Atg5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Atg5 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002293GA01HU | ATG5 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA028037 | ATG5 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA931023 | ATG5 Antibody |
Human,Mouse,Rat | ELISA,IHC |
| CSB-PA15499A0Rb | ATG5 Antibody |
Human | ELISA, IHC, IF |
| CSB-PA15499B0Rb | ATG5 Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA334611 | ATG5 Antibody |
Human,Mouse,Rat | IHC, ELISA |
| CSB-MA518180 | ATG5 Monoclonal Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-MA172954 | ATG5 Monoclonal Antibody |
Human,Mouse,Rat | ELISA,IHC |
Atg5 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA880718XA01DOA | ATG5 Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Drosophila melanogaster (Fruit fly)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA895235XA01DLU | Atg5 Antibody |
Drosophila melanogaster (Fruit fly) | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Oryza sativa subsp. indica (Rice)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002293XA01OFF | ATG5 Antibody |
Oryza sativa subsp. indica (Rice) | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Oryza sativa subsp. japonica (Rice)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA761620XA01OFG | ATG5 Antibody |
Oryza sativa subsp. japonica (Rice) | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002293XA01STA | ATG5 Antibody |
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA619592XA01SVG | ATG5 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA765661XA01DOT | ATG5 Antibody |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) | ELISA, WB (ensure identification of antigen) |
Atg5 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002293XA01SXV | atg5 Antibody |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
Atg5 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293CTL CSB-EP002293CTL CSB-BP002293CTL CSB-MP002293CTL CSB-EP002293CTL-B |
Recombinant Cryptococcus neoformans var. neoformans serotype D Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293CTK CSB-EP002293CTK CSB-BP002293CTK CSB-MP002293CTK CSB-EP002293CTK-B |
Recombinant Cryptococcus neoformans var. neoformans serotype D Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293AVC CSB-EP002293AVC CSB-BP002293AVC CSB-MP002293AVC CSB-EP002293AVC-B |
Recombinant Aspergillus clavatus Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293NEZ CSB-EP002293NEZ CSB-BP002293NEZ CSB-MP002293NEZ CSB-EP002293NEZ-B |
Recombinant Neosartorya fischeri Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Oryza sativa subsp. indica (Rice)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293OFF CSB-EP002293OFF CSB-BP002293OFF CSB-MP002293OFF CSB-EP002293OFF-B |
Recombinant Oryza sativa subsp. indica Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293SXM CSB-EP002293SXM CSB-BP002293SXM CSB-MP002293SXM CSB-EP002293SXM-B |
Recombinant Scheffersomyces stipitis Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293LLV CSB-EP002293LLV CSB-BP002293LLV CSB-MP002293LLV CSB-EP002293LLV-B |
Recombinant Lodderomyces elongisporus Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293MTM CSB-EP002293MTM CSB-BP002293MTM CSB-MP002293MTM CSB-EP002293MTM-B |
Recombinant Meyerozyma guilliermondii Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293STA CSB-EP002293STA CSB-BP002293STA CSB-MP002293STA CSB-EP002293STA-B |
Recombinant Saccharomyces cerevisiae Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293AUN CSB-EP002293AUN CSB-BP002293AUN CSB-MP002293AUN CSB-EP002293AUN-B |
Recombinant Ajellomyces capsulata Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293STG CSB-EP002293STG CSB-BP002293STG CSB-MP002293STG CSB-EP002293STG-B |
Recombinant Sclerotinia sclerotiorum Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293VDW CSB-EP002293VDW CSB-BP002293VDW CSB-MP002293VDW CSB-EP002293VDW-B |
Recombinant Vanderwaltozyma polyspora Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Pichia angusta (Yeast) (Hansenula polymorpha)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293EVQ CSB-EP002293EVQ CSB-BP002293EVQ CSB-MP002293EVQ CSB-EP002293EVQ-B |
Recombinant Pichia angusta Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293ETH CSB-EP002293ETH CSB-BP002293ETH CSB-MP002293ETH CSB-EP002293ETH-B |
Recombinant Penicillium chrysogenum Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002293SXV CSB-EP002293SXV CSB-BP002293SXV CSB-MP002293SXV CSB-EP002293SXV-B |
Recombinant Schizosaccharomyces pombe Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP607708APT CSB-EP607708APT CSB-BP607708APT CSB-MP607708APT CSB-EP607708APT-B |
Recombinant Aspergillus terreus Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP611707EUG CSB-EP611707EUG CSB-BP611707EUG CSB-MP611707EUG CSB-EP611707EUG-B |
Recombinant Phaeosphaeria nodorum Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP619592SVG CSB-EP619592SVG CSB-BP619592SVG CSB-MP619592SVG CSB-EP619592SVG-B |
Recombinant Saccharomyces cerevisiae Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP627749DUV CSB-EP627749DUV CSB-BP627749DUV CSB-MP627749DUV CSB-EP627749DUV-B |
Recombinant Coccidioides immitis Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP646242CHI CSB-EP646242CHI CSB-BP646242CHI CSB-MP646242CHI CSB-EP646242CHI-B |
Recombinant Chaetomium globosum Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP648816DPA CSB-EP648816DPA CSB-BP648816DPA CSB-MP648816DPA CSB-EP648816DPA-B |
Recombinant Aspergillus oryzae Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Sus scrofa (Pig)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP659534PI CSB-EP659534PI CSB-BP659534PI CSB-MP659534PI CSB-EP659534PI-B |
Recombinant Pig Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP662142BO CSB-EP662142BO CSB-BP662142BO CSB-MP662142BO CSB-EP662142BO-B |
Recombinant Bovine Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP664751RA CSB-EP664751RA CSB-BP664751RA CSB-MP664751RA CSB-EP664751RA-B |
Recombinant Rat Autophagy protein 5 (Atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP687235NGS CSB-EP687235NGS CSB-BP687235NGS CSB-MP687235NGS CSB-EP687235NGS-B |
Recombinant Neosartorya fumigata Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP687438MPM CSB-EP687438MPM CSB-BP687438MPM CSB-MP687438MPM CSB-EP687438MPM-B |
Recombinant Magnaporthe oryzae Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP701596CZD CSB-EP701596CZD CSB-BP701596CZD CSB-MP701596CZD CSB-EP701596CZD-B |
Recombinant Candida albicans Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP701662EKF CSB-EP701662EKF CSB-BP701662EKF CSB-MP701662EKF CSB-EP701662EKF-B |
Recombinant Emericella nidulans Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Dictyostelium discoideum (Slime mold)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP706720DKK CSB-EP706720DKK CSB-BP706720DKK CSB-MP706720DKK CSB-EP706720DKK-B |
Recombinant Dictyostelium discoideum Autophagy protein 5 (atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP722312PYX CSB-EP722312PYX CSB-BP722312PYX CSB-MP722312PYX CSB-EP722312PYX-B |
Recombinant Pongo abelii Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP728218DIS CSB-EP728218DIS CSB-BP728218DIS CSB-MP728218DIS CSB-EP728218DIS-B |
Recombinant Debaryomyces hansenii Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP735097KBK CSB-EP735097KBK CSB-BP735097KBK CSB-MP735097KBK CSB-EP735097KBK-B |
Recombinant Kluyveromyces lactis Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP738280YAP CSB-EP738280YAP CSB-BP738280YAP CSB-MP738280YAP CSB-EP738280YAP-B |
Recombinant Yarrowia lipolytica Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP738895CZI CSB-EP738895CZI CSB-BP738895CZI CSB-MP738895CZI CSB-EP738895CZI-B |
Recombinant Candida glabrata Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Oryza sativa subsp. japonica (Rice)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP761620OFG CSB-EP761620OFG CSB-BP761620OFG CSB-MP761620OFG CSB-EP761620OFG-B |
Recombinant Oryza sativa subsp. japonica Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP765661DOT CSB-EP765661DOT CSB-BP765661DOT CSB-MP765661DOT CSB-EP765661DOT-B |
Recombinant Ashbya gossypii Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP859123MO CSB-EP859123MO CSB-BP859123MO CSB-MP859123MO CSB-EP859123MO-B |
Recombinant Mouse Autophagy protein 5 (Atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP863954HU CSB-EP863954HU CSB-BP863954HU CSB-MP863954HU CSB-EP863954HU-B |
Recombinant Human Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP880718DOA CSB-EP880718DOA CSB-BP880718DOA CSB-MP880718DOA CSB-EP880718DOA-B |
Recombinant Arabidopsis thaliana Autophagy protein 5 (ATG5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Atg5 Proteins for Drosophila melanogaster (Fruit fly)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP895235DLU CSB-EP895235DLU CSB-BP895235DLU CSB-MP895235DLU CSB-EP895235DLU-B |
Recombinant Drosophila melanogaster Autophagy protein 5 (Atg5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Autophagy protein 5 is a protein in humans that is encoded by the ATG5 gene. ATG5 is involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme that is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. ATG5 is also implicated in mitochondrial quality control after oxidative damage and subsequent cellular longevity. It plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. ATG5 is involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through the removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
