BCL2A1 (BCL2 Related Protein A1) is a Protein Coding gene. Diseases associated with BCL2A1 include Gingival Recession and Endogenous Depression. Among its related pathways are Direct p53 effectors and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
The following recombinant BCL2A1 proteins are manufactured in house under a complete QC system by CUSABIO. They are expressed by Yeast, E.coli, Baculovirus, Mammalian cell, In Vivo Biotinylation in E.coli. Highlights of these recombinant BCL2A1 proteins as follow:
High purity, Low endotoxin, Multiple Tags, Animal-free, Wide applications (Cell assay, Protein-protein interaction, Drug-related studies, Enzymatic activity in vitro, Protein structure analysis, etc.)
In addition, various options on sizes, excellent technical support, and recombinant BCL2A1 proteins custom service will be also offered.
BCL2A1 Proteins for Homo sapiens (Human)
In Vivo Biotinylation in E.coli
BCL2A1 Proteins for Bos taurus (Bovine)
In Vivo Biotinylation in E.coli
Bcl-2-related protein A1 also called Bcl-2 related gene expressed in fetal liver (Bfl-1), is a protein in humans that is encoded by the BCL2A1 gene on chromosome 15q24.3 . BCL2A1 possesses four BH-domain: BH1-BH4. Crystal structures of BCL2A1 in complex with BH3-peptides revealed that it displays a similar hydrophobic groove as observed on all related anti-apoptotic Bcl-2 (B-cell lymphoma 2) proteins . Although BCL2A1 does not exhibit a well-defined C-terminal transmembrane domain identified in other anti-apoptotic Bcl-2 proteins, its C-terminus is essential for the anti-apoptotic function and the subcellular localization of BCL2A1 . BCL2A1 protein is particularly important in the hematopoietic system  and executes its anti-apoptotic function by sequestering pro-apoptotic BCL2 proteins . The transcription of BCL2A1 is induced by NF-kappa B, retinoic X receptors (RXR) agonists , and WT-1 , but inhibited by the plasma cell transcription factor PRDI-BF1/Blimp-1 . The identification of BCL2A1 as an NF-κB target gene shows that the formation of inflammasomes may also induce the expression of BCL2A1, thus promoting the survival of the pro-inflammatory cells during inflammation. The stability of BCL2A1 protein is regulated by proteasomal degradation . BCL2A1 overexpression has been found in various hematological malignancies  as well as solid tumors  and seems to be notably associated with advanced or metastatic disease stages . Besides a potential role in tumorigenesis, BCL2A1 overexpression is also involved in the resistance for chemotherapy.
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