CTSO Antibodies

CTSO (Cathepsin O) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSS.

Based on more than 13 years of development, CUSABIO has established a mature and efficient system for antibody preparation. The following CTSO antibodies are manufactured under the system.
These CTSO antibodies are featured with high specificity & sensitivity and wide species reactivity. In order to meet different requirements, CUSABIO is trying to include more antibody types (Monoclonal, Polyclonal, Recombinant, etc) and do more validations so that the researchers can break limits and discover more. In addition, CUSABIO also provides CTSO antibody custom service in case you have specific needs for your research.

CTSO Antibodies Catalog

CTSO Antibodies for Homo sapiens (Human)

CTSO Background

CTSO, a gene initially cloned from a breast cancer cell library [1], was found to be mapped to chromosome 4q31-q32, which is a unique localization for cysteine proteases [2]. The gene coding enzyme CTSO is a cysteine endopeptidase that is broadly distributed in tissues, but with the highest expression in the human ovary, kidney, liver, and placenta [2]. The ubiquitous distribution of CTSO is consistent with its role in the involvement in normal cellular protein degradation and turnover [1]. CTSO is synthesized as a 329-amino acid pre-pro-enzyme with more than 50% identity to both human cathepsin S and cathepsin L and 94% identity to a rabbit cDNA, termed OC2, recently isolated from osteoclasts [3]. The sequence contains a signal peptide and a pro-domain presumably involved in maintaining enzyme latency. Removal of the pro-domain activates CTSO in the acidic lysosomal compartment. Preliminary investigations of the enzymatic activity of CTSO expressed in E. coli revealed that CTSO can cleave the substrates Z-Phe-Arg-MCA and Z-Arg-Arg-MCA although at lower rates than cathepsin B. When transfected into COS-7 cells, CTSO displayed potent endoprotease activity against fibrinogen at acid pH [3]. This proteolytic enzyme CTSO is involved in cellular protein degradation and turnover.

[1] Velasco G, Ferrando AA, et al. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues [J]. J Biol Chem. 1994 Oct 28; 269(43):27136-42.
[2] Santamaría I, Pendás AM, et al. Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO) [J]. Genomics. 1998 Oct 15; 53(2):231-4.
[3] G P Shi, H A Chapman, et al. Molecular Cloning of Human Cathepsin O, a Novel Endoproteinase and Homologue of Rabbit OC2 [J]. FEBS Lett, 1995, 357 (2), 129-34.

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