CTSW Proteins

CTSW (Cathepsin W) is a Protein Coding gene. Diseases associated with CTSW include Autoimmune Atrophic Gastritis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSF.

CUSABIO has five systems (E. coli, In vitro E.coli, Yeast, Insect Baculovirus, Mammalian) from prokaryotic to eukaryotic to express the recombinant protein, and a very strict QC system so that the quality can be guaranteed. And the following CTSW proteins are produced under the system.
CTSW proteins produced by CUSABIO are featured with high purity, low endotoxin, multi-Sources & tags, animal-free, etc. And you will have many choices on sizes from μg to mg. In addition, CTSW custom service is also available for research with more specific needs.

CTSW Proteins Catalog

CTSW Proteins for Homo sapiens (Human)

CTSW Proteins for Mus musculus (Mouse)

CTSW Proteins for Felis catus (Cat) (Felis silvestris catus)

CTSW Proteins for Mus musculus(Mouse)

CTSW Background

Cathepsin W, a cysteine endopeptidase of the papain family, is encoded by the CTSW gene that mapped to 11q13.1 [1]. The CTSW gene is tightly linked to cathepsin F, on human chromosome 11q13 [2]. So CTSW is highly similar to CTSF. CTSW consists of a putative 21-residue signal peptide, a 106-residue propeptide, and a 252-residue mature protein [3]. A 21-aa insertion between the His291 (numbering from the Met start residue) and Asn331 that contains a serine-proline-glutamine rich stretch (SSQSQPQPP) in CTSW makes it unique in the cathepsins. CTSW contains a fourth disulfide bond that is absent in other cathepsins, as well as an “orphan” cysteine (Cys132) capable of contributing to dimerization [4]. The 8-aa C-terminal extension in CTSW is also not found in other cathepsins [3]. CTSW is mainly expressed in CD8+ lymphocytes and natural killer (NK) cells [5] and may exert a role in cell-mediated cytotoxicity [3][6]. The expression of CTSW is upregulated by interleukin (IL)-2 [7]. CTSW is detected in up to 65% of CD45+ cells in autoimmune gastritis [8]. In contrast, the number of CTSW-expressing cells in Crohn's disease and ulcerative colitis is much lower [8]. These differences imply a distinct involvement of cytotoxic cells expressing CTSW in the pathogenesis among these diseases.

[1] Wex T, Levy B, et al. Genomic structure, chromosomal localization, and expression of human cathepsin W [J]. Biochem Biophys Res Commun. 1998 Jul 20; 248(2):255-61.
[2] Wex, T., Buhling, F., et al. Human Cathepsins F and W: A New Subgroup of Cathepsins [J]. Biochem. Biophys. Res. Commun. 1999, 259, 401-407.
[3] Linnevers, C., Smeekens, S. P., et al. Human Cathepsin W, a Putative Cysteine Protease Predominantly Expressed in CD8+ T-lymphocytes [J]. FEBS Lett. 1997, 405, 253-259.
[4] Brinkworth, R. I., Tort, J. F., et al. Phylogenetic Relationships and Theoretical Model of Human Cathepsin W (Lymphopain), a Cysteine Proteinase From Cytotoxic T Lymphocytes [J]. Int. J. Biochem. Cell Biol. 2000, 32, 373-384.
[5] T. Wex, H. Wex, R. Hartig, et al. Functional involvement of cathepsin W in the cytotoxic activity of NK-92 cells [J]. FEBS Lett., 552 (2003), pp. 115-119.
[6] Wex T, Bühling F, et al. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum [J]. J Immunol. 2001 Aug 15; 167(4):2172-8.
[7] Thomas Wex, Frank Bühlin, et al. Human Cathepsin W, a Cysteine Protease Predominantly Expressed in NK Cells, Is Mainly Localized in the Endoplasmic Reticulum [J]. J Immunol August 15, 2001, 167 (4) 2172-2178.
[8] Frank Buhling, Udo Kellner, et al. Characterization of Novel Anti-Cathepsin W Antibodies and Cellular Distribution of Cathepsin W in the Gastrointestinal Tract [J]. Biol. Chem. 2002, 383, 1285-1289.


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