CTSZ (Cathepsin Z) is a Protein Coding gene. Diseases associated with CTSZ include Cercarial Dermatitis and Mitochondrial Complex V Deficiency, Nuclear Type 5. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSC.
Based on more than 13 years of development, CUSABIO has established a mature and efficient system for antibody preparation. The following CTSZ antibodies are manufactured under the system.
These CTSZ antibodies are featured with high specificity & sensitivity and wide species reactivity. In order to meet different requirements, CUSABIO is trying to include more antibody types (Monoclonal, Polyclonal, Recombinant, etc) and do more validations so that the researchers can break limits and discover more. In addition, CUSABIO also provides CTSZ antibody custom service in case you have specific needs for your research.
CTSZ Antibodies for Homo sapiens (Human)
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The CTSZ gene mapped to chromosome 20q13 codes for a unique lysosomal cysteine cathepsin Z , which is expressed primarily by antigen-presenting cells. CTSZ is the only enzyme with strict carboxypeptidase activity . Like other cathepsins, CTSZ is produced as a pre-pro-cathepsin Z and then processed to pro-cathepsin Z containing an RGD motif. The RGD motif is located in a highly exposed region of the propeptide, which may allow binding of the proenzyme to RGD-recognizing integrins , and thus modulating the attachment of migrating cells to ECM components. In the context of neoplasia, there is recent in vivo evidence for a tumor-promoting role for the carboxypeptidase as well as for the RGD function of CTSZ . CTSZ can upregulate the proteins associated with extracellular matrix (ECM) remodeling such as MMP2, MMP3, and MMP9, thus indicating that CTSZ might play an important role in hepatocellular carcinoma invasion and metastasis . CTSZ is disproportionately expressed and secreted by both microglia and astrocytes in response to neuronal damage and inflammatory stimulus, both in culture and in vivo . It was reported that dendritic cells in the aging brains of mice had increased expression of CTSZ that associated with known markers of neuroinflammation . Euan R. O. Allan et al. demonstrated that CTSZ promotes the IL-1β-Th17 axis leading to more severe neuroinflammation during experimental autoimmune encephalomyelitis (EAE) and may support a new role for CTSZ in the propagation of IL-1β-driven neuroinflammation . And it may suggest that CTSZ plays a role in the development of multiple sclerosis (MS), as proposed by Huynh et al.  .
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 Euan R. O. Allan, Rhiannon I. Campden, et al. A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis [J]. J Neuroinflammation. 2017; 14: 103.
 Huynh JL, Garg P, et al. Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains [J]. Nat Neurosci. 2014 Jan; 17(1):121-30.