ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Protein Coding gene. Diseases associated with ERN1 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 5 and Ciliary Dyskinesia, Primary, 3. Among its related pathways are Autophagy - animal and Apoptosis-related network due to altered Notch3 in ovarian cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERN2.
Based on more than 13 years of development, CUSABIO has established a mature and efficient system for antibody preparation. The following ERN1 antibodies are manufactured under the system.
These ERN1 antibodies are featured with high specificity & sensitivity and wide species reactivity. In order to meet different requirements, CUSABIO is trying to include more antibody types (Monoclonal, Polyclonal, Recombinant, etc) and do more validations so that the researchers can break limits and discover more. In addition, CUSABIO also provides ERN1 antibody custom service in case you have specific needs for your research.
ERN1 Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
|CSB-RA007795A724phHU||Human||ELISA, WB, IF|
Endoplasmic reticulum (ER) to nucleus signaling 1 protein, referred to as ERN1, is a human homologue of the yeast IRE1 ((inositol-requiring enzyme-1), so it is also called human IRE1α. ERN1 contains a cytoplasmic domain that is highly conserved to the yeast counterpart having a Ser/Thr protein kinase domain and a domain homologous to RNase L. ERN1/IRE1α is a special transmembrane sensor protein indispensable for the ER unfolded protein response (UPR). In unstressed cells, the ER luminal domain retains inactive as a monomer by binding to the ER chaperone HSPA5/BiP. Misfolded proteins build up in the ER, causing the release of HSPA5/BiP, which allows the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. Activation of ERN1 by the association of its N-terminal ER luminal domains promotes autophosphorylation by its cytoplasmic kinase domain, leading to activation of the C-terminal ribonuclease domain, which splices Xbp1 mRNA generating an active Xbp1s transcriptional activator.
 Ali MM1, Bagratuni T, et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response [J]. EMBO J. 2011 Mar 2;30(5):894-905.