FAS Proteins

FAS (Fas Cell Surface Death Receptor) is a Protein Coding gene. Diseases associated with FAS include Autoimmune Lymphoproliferative Syndrome and Lymphoproliferative Syndrome. Among its related pathways are Direct p53 effectors and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is LTBR.

CUSABIO has five systems (E. coli, In vitro E.coli, Yeast, Insect Baculovirus, Mammalian) from prokaryotic to eukaryotic to express the recombinant protein, and a very strict QC system so that the quality can be guaranteed. And the following FAS proteins are produced under the system.
FAS proteins produced by CUSABIO are featured with high purity, low endotoxin, multi-Sources & tags, animal-free, etc. And you will have many choices on sizes from μg to mg. In addition, FAS custom service is also available for research with more specific needs.

FAS Proteins Catalog

FAS Proteins for Homo sapiens (Human)

FAS Proteins for Rattus norvegicus (Rat)

FAS Proteins for Macaca nemestrina (Pig-tailed macaque)

FAS Proteins for Macaca mulatta (Rhesus macaque)

FAS Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

FAS Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

FAS Proteins for Bos taurus (Bovine)

FAS Proteins for Mus musculus (Mouse)

FAS Proteins for Sus scrofa (Pig)

FAS Background

FAS, also known as CD95/Apo-1/TNFRSF6, is a type I transmembrane (TM) protein on the cell surface, and a death receptor that belongs to the TNF-receptor superfamily [1]. Fas contains an N-terminal ligand-binding extracellular domain (ECD), a TM domain, and a C-terminal cytoplasmic death domain (DD) [1]. Expressed at the cell surface as a homotrimer, the FAS receptor implements both apoptotic and non-apoptotic signaling pathways. The ligation of FAS with FAS ligand (FASL) leads to the activation of a caspase cascade that initiates apoptosis [2][3][4]. FAS triggers apoptosis through FADD-mediated recruitment and activation of caspase-8 [5]. Fas–FasL-induced apoptosis is an important mechanism for the maintenance of immune homeostasis &peripheral tolerance, and the surveillance of tumor [6]. Its non-apoptotic cues seem to promote oncogenesis [7]. FAS/CD95 engagement also induces non-apoptotic signaling pathways promoting cell motility, invasiveness [8], inflammation, and organ regeneration. A large fraction of human ALPS (autoimmune lymphoproliferative syndrome) patients have heterozygous inherited mutations in the FAS gene [9]. ALPS is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). In consideration of the multiple roles of Fas–FasL in immune responses and diseases, therapeutic targets of the Fas/FasL pathway might not protect against a specific disease rather than influencing the patient's prognosis.

[1] Wu H, Hymowitz SG. Structure and function of tumor necrosis factor (TNF) at the cell surface. In: Bradshaw RA, Dennis EA, editors. Handbook of cell signaling [J]. Oxford: Academic Press; 2009. pp. 265–275.
[2] Nagata S, Golstein P. The Fas death factor [J]. Science (1995) 267(5203):1449–56.
[3] Chinnaiyan AM, O’Rourke K, et al. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis [J]. Cell (1995) 81:505–12.
[4] Kischkel FC, Hellbardt S, et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor [J]. EMBO J (1995) 14:5579–88.
[5] Nagata S. Apoptosis by death factor [J]. Cell (1997) 88(3):355–65.
[6] Strasser A, Jost PJ, et al. The many roles of FAS receptor signaling in the immune system [J]. Immunity. 2009 Feb 20;30(2):180-92.
[7] Le Gallo M, Poissonnier A, et al. CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases [J]. Front Immunol. 2017 Sep 27; 8:1216.
[8] Nijkamp MW, Hoogwater FJ, et al. CD95 is a key mediator of invasion and accelerated outgrowth of mouse colorectal liver metastases following radiofrequency ablation [J]. J Hepatol. 2010 Dec;53(6):1069-77.
[9] Dowdell KC, Niemela JE, et al. Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome [J]. Blood. 2010 Jun 24;115(25):5164-9.

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