Hypoxia-inducible factor 1-alpha is a protein in humans that is encoded by HIF1A gene. Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2.

Hif1a Antibodies

Hif1a Antibodies for Homo sapiens (Human)

Hif1a Proteins

Hif1a Proteins for Rattus norvegicus (Rat)

Hif1a Proteins for Bos mutus grunniens (Wild yak) (Bos grunniens)

Hif1a Proteins for Homo sapiens (Human)

Hif1a Proteins for Eospalax fontanierii baileyi (Plateau zokor) (Eospalax baileyi)

Hif1a Proteins for Mus musculus (Mouse)

Hif1a Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Hif1a Proteins for Xenopus laevis (African clawed frog)

Hif1a Proteins for Bos taurus (Bovine)

Hif1a Proteins for Gallus gallus (Chicken)

Hif1a ELISA Kit

Hif1a ELISA Kit for Homo sapiens (Human)

Hif1a ELISA Kit for Mus musculus (Mouse)

Hif1a ELISA Kit for Rattus norvegicus (Rat)


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