Insulin receptor is a protein in humans that is encoded by INSR gene. Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways.
The following Insr reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Insr Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011753GA01HU | INSR Antibody |
Human,Rat | ELISA,WB,IP |
CSB-PA202534 | Phospho-INSR (Tyr1361) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA203919 | Phospho-INSR (Tyr1355) Antibody |
Human | ELISA,WB |
CSB-PA945193 | INSR (Ab-1375) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA994563 | Phospho-INSR (Thr1375) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA003043 | INSR Antibody |
Human,Mouse,Rat,Monkey | WB, ELISA |
CSB-PA011224 | Phospho-INSR (T1375) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011225 | Phospho-INSR (Y1355) Antibody |
Human | WB, IHC, ELISA |
CSB-PA011226 | Phospho-INSR (Y1361) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011227 | INSR Antibody |
Human,Mouse,Rat | IF, ELISA |
CSB-PA011228 | INSR Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011229 | INSR Antibody |
Human | IHC, IF, ELISA |
CSB-PA410086 | INSR Antibody |
Human | IHC,ELISA |
CSB-PA011753LA01HU | INSR Antibody |
Human | ELISA, IHC, IF |
CSB-PA011753LB01HU | INSR Antibody, HRP conjugated |
Human | ELISA |
CSB-PA011753LC01HU | INSR Antibody, FITC conjugated |
Human | |
CSB-PA011753LD01HU | INSR Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA155156A0HU | INSR Recombinant Monoclonal Antibody |
Human | ELISA, IF |
Insr Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP011753HU | Recombinant Human Insulin receptor (INSR), partial,Yeast |
Yeast |
CSB-CF011753HU | Recombinant Human Insulin receptor (INSR) |
in vitro E.coli expression system |
CSB-EP011753HU | Recombinant Human Insulin receptor (INSR),Partial |
E.coli |
CSB-BP011753HU CSB-MP011753HU CSB-EP011753HU-B |
Recombinant Human Insulin receptor (INSR), partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Insr Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP011753XBE CSB-EP011753XBE CSB-BP011753XBE CSB-MP011753XBE CSB-EP011753XBE-B |
Recombinant Xenopus laevis Insulin receptor (insr), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Insr Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP011753MOW CSB-EP011753MOW CSB-BP011753MOW CSB-MP011753MOW CSB-EP011753MOW-B |
Recombinant Macaca mulatta Insulin receptor (INSR) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Insr Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF011753MO | Recombinant Mouse Insulin receptor (Insr) |
in vitro E.coli expression system |
CSB-YP011753MO1 CSB-EP011753MO1 CSB-BP011753MO1 CSB-MP011753MO1 CSB-EP011753MO1-B |
Recombinant Mouse Insulin receptor (Insr), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Insr Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP011753RA CSB-EP011753RA1 CSB-BP011753RA1 CSB-MP011753RA1 CSB-EP011753RA-B |
Recombinant Rat Insulin receptor (Insr), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |