NGF Antibodies

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3.

CUSABIO offers an extensive catalog of antibodies to take your research to the next level. We supply polyclonal antibodies and monoclonal antibodies as well as recombinant antibodies to meet different experiment requirements. In order to ensure quality, every single production process is controlled strictly. And the following NGF antibodies are manufactured under such a strict QC system.
These NGF antibodies have multiple immunogens, host species, applications and size options from sample size to bulk ones. You can also choose our NGF antibody custom service to create the antibodies for your research. Our technical team will be here to support you.

NGF Antibodies Catalog

NGF Antibodies for Rattus norvegicus (Rat)

NGF Antibodies for Homo sapiens (Human)

NGF Antibodies for Sus scrofa (Pig)

NGF Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

NGF Background

The NGF gene provides instructions for making a protein called nerve growth factor beta (NGFβ). As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory neurons, as they undergo apoptosis in its absence[1]. The NGFβ protein functions by binding to its receptors, which initiates signaling pathways inside the cell. The NGFβ protein can bind to two different receptors, the NTRK1 receptor or the p75NTR receptor. Both receptors are found on the surface of sensory neurons and other types of neurons. The binding of the NGFβ protein to the NTRK1 receptor signals these neurons to grow and to mature and take on specialized functions (differentiate). This binding also blocks signals that initiate the process of self-destruction (apoptosis). Additionally, NGFβ signaling through NTRK1 plays a role in pain sensation. It is less clear what binding with the p75NTR receptor signals. Studies suggest that p75NTR signaling can help sensory neurons grow and differentiate but can also trigger apoptosis. However, several recent studies suggest that NGF is also involved in pathways regulating the life cycle of neurons.

[1] Freeman RS, Burch RL, et al. NGF deprivation-induced gene expression: after ten years, where do we stand [J]? Progress in Brain Research. 2004, 146: 111–26.

 

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