NGF Proteins

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are p75(NTR)-mediated signaling and NGF Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3.

With so many years of experience in developing and manufacturing recombinant proteins, CUSABIO has established stringent purification and production standards to ensure the quality of our protein products.
The following NGF proteins are prepared according to the strict standard, so you will have no worries about the quality. These proteins have high purity, low endotoxin and lot-to-lot consistency. If you can't find the proteins in the catalog, our custom services will make the protein that fits your experimental needs.

NGF Proteins Catalog

NGF Proteins for Bos taurus (Bovine)

NGF Proteins for Cavia porcellus (Guinea pig)

NGF Proteins for Rattus norvegicus (Rat)

NGF Proteins for Homo sapiens (Human)

NGF Proteins for Gallus gallus (Chicken)

NGF Proteins for Mus musculus (Mouse)

NGF Proteins for Mastomys natalensis (African soft-furred rat) (Praomys natalensis)

NGF Proteins for Xenopus laevis (African clawed frog)

NGF Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)

NGF Proteins for Sus scrofa (Pig)

NGF Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

NGF Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

NGF Proteins for Bothrops jararacussu (Jararacussu)

NGF Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

NGF Proteins for Pongo pygmaeus (Bornean orangutan)

NGF Proteins for Pan troglodytes (Chimpanzee)

NGF Background

The NGF gene provides instructions for making a protein called nerve growth factor beta (NGFβ). As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory neurons, as they undergo apoptosis in its absence[1]. The NGFβ protein functions by binding to its receptors, which initiates signaling pathways inside the cell. The NGFβ protein can bind to two different receptors, the NTRK1 receptor or the p75NTR receptor. Both receptors are found on the surface of sensory neurons and other types of neurons. The binding of the NGFβ protein to the NTRK1 receptor signals these neurons to grow and to mature and take on specialized functions (differentiate). This binding also blocks signals that initiate the process of self-destruction (apoptosis). Additionally, NGFβ signaling through NTRK1 plays a role in pain sensation. It is less clear what binding with the p75NTR receptor signals. Studies suggest that p75NTR signaling can help sensory neurons grow and differentiate but can also trigger apoptosis. However, several recent studies suggest that NGF is also involved in pathways regulating the life cycle of neurons.

[1] Freeman RS, Burch RL, et al. NGF deprivation-induced gene expression: after ten years, where do we stand [J]? Progress in Brain Research. 2004, 146: 111–26.

 

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