NTRK1 Antibodies

NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with NTRK1 include Insensitivity To Pain, Congenital, With Anhidrosis and Thyroid Carcinoma, Familial Medullary. Among its related pathways are NGF Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is NTRK3.

CUSABIO offers an extensive catalog of antibodies to take your research to the next level. We supply polyclonal antibodies and monoclonal antibodies as well as recombinant antibodies to meet different experiment requirements. In order to ensure quality, every single production process is controlled strictly. And the following NTRK1 antibodies are manufactured under such a strict QC system.
These NTRK1 antibodies have multiple immunogens, host species, applications and size options from sample size to bulk ones. You can also choose our NTRK1 antibody custom service to create the antibodies for your research. Our technical team will be here to support you.

NTRK1 Antibodies Catalog

NTRK1 Antibodies for Homo sapiens (Human)

NTRK1 Background

The NTRK1 gene encodes a protein that is essential for the development and survival of neurons, especially those that transmit information about sensations such as pain, temperature, and sensory neurons[1]. The NTRK1 protein is found on the surface of cells, particularly sensory neurons. It acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and a phosphate group at specific positions, a process known as phosphorylation. The NTRK1 protein is activated when another protein called nerve growth factor beta (NGFβ) binds to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). The activated NTRK1 protein and then phosphorylates other proteins, thus finishing the delivery of signals for cell growth and survival. Gene fusions involving NTRK1 have been shown to be oncogenic, leading to the constitutive TrkA activation[2]. Mutations in NTRK1 gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers.

[1] Martin-Zanca D, Hughes SH, et al. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences [J]. Nature. 1986, 319 (6056): 743–8.
[2] Vaishnavi, Aria; Capelletti, Marzia; et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer [J]. Nature Medicine. 2013, 19 (11): 1469–1472.

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