Receptor-interacting serine/threonine-protein kinase 1 is a protein in humans that is encoded by RIPK1 gene. Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation.

Ripk1 Antibodies

Ripk1 Antibodies for Homo sapiens (Human)

Ripk1 Antibodies for Mouse

Ripk1 Antibodies for Mus musculus (Mouse)

Ripk1 Proteins

Ripk1 Proteins for Homo sapiens (Human)

Ripk1 Proteins for Mus musculus (Mouse)

Ripk1 Proteins for Mus musculus(Mouse)

Ripk1 ELISA Kit

Ripk1 ELISA Kit for Mus musculus (Mouse)


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