atg7

Ubiquitin-like modifier-activating enzyme ATG7 is a protein in humans that is encoded by ATG7 gene. E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.

The following atg7 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

atg7 Antibodies

atg7 Proteins

atg7 ELISA Kits

atg7 Antibodies

atg7 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002294GA01HU	ATG7 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA002294LA01HU	ATG7 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA443647	ATG7 Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-MA617582	ATG7 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC

atg7 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA842475XA01DOA	ATG7 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

atg7 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

Code	Product Name	Species Reactivity	Application
CSB-PA765622XA01DOT	ATG7 Antibody	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)	ELISA, WB (ensure identification of antigen)

atg7 Antibodies for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA002294XA01STA	ATG7 Antibody	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

atg7 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA002294XA01SVG	ATG7 Antibody	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

atg7 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA002294XA01SXV	atg7 Antibody	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ELISA, WB (ensure identification of antigen)

atg7 Proteins

atg7 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP002294HU CSB-EP002294HU CSB-BP002294HU CSB-MP002294HU CSB-EP002294HU-B	Recombinant Human Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

Code	Product Name	Source
CSB-YP002294CTL CSB-EP002294CTL CSB-BP002294CTL CSB-MP002294CTL CSB-EP002294CTL-B	Recombinant Cryptococcus neoformans var. neoformans serotype D Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)

Code	Product Name	Source
CSB-YP002294CTK CSB-EP002294CTK CSB-BP002294CTK CSB-MP002294CTK CSB-EP002294CTK-B	Recombinant Cryptococcus neoformans var. neoformans serotype D Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Source
CSB-YP002294SVG CSB-EP002294SVG CSB-BP002294SVG CSB-MP002294SVG CSB-EP002294SVG-B	Recombinant Saccharomyces cerevisiae Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)

Code	Product Name	Source
CSB-YP002294SXM CSB-EP002294SXM CSB-BP002294SXM CSB-MP002294SXM CSB-EP002294SXM-B	Recombinant Scheffersomyces stipitis Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)

Code	Product Name	Source
CSB-YP002294MTM CSB-EP002294MTM CSB-BP002294MTM CSB-MP002294MTM CSB-EP002294MTM-B	Recombinant Meyerozyma guilliermondii Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)

Code	Product Name	Source
CSB-YP002294LLV CSB-EP002294LLV CSB-BP002294LLV CSB-MP002294LLV CSB-EP002294LLV-B	Recombinant Lodderomyces elongisporus Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)

Code	Product Name	Source
CSB-YP002294AUN CSB-EP002294AUN CSB-BP002294AUN CSB-MP002294AUN CSB-EP002294AUN-B	Recombinant Ajellomyces capsulata Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

Code	Product Name	Source
CSB-YP002294STA CSB-EP002294STA CSB-BP002294STA CSB-MP002294STA CSB-EP002294STA-B	Recombinant Saccharomyces cerevisiae Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)

Code	Product Name	Source
CSB-YP002294STG CSB-EP002294STG CSB-BP002294STG CSB-MP002294STG CSB-EP002294STG-B	Recombinant Sclerotinia sclerotiorum Ubiquitin-like modifier-activating enzyme atg7 (atg7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Pichia angusta (Yeast) (Hansenula polymorpha)

Code	Product Name	Source
CSB-YP002294EVQ CSB-EP002294EVQ CSB-BP002294EVQ CSB-MP002294EVQ CSB-EP002294EVQ-B	Recombinant Pichia angusta Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)

Code	Product Name	Source
CSB-YP002294ETH CSB-EP002294ETH CSB-BP002294ETH CSB-MP002294ETH CSB-EP002294ETH-B	Recombinant Penicillium chrysogenum Ubiquitin-like modifier-activating enzyme atg7 (atg7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)

Code	Product Name	Source
CSB-YP002294VDW CSB-EP002294VDW CSB-BP002294VDW CSB-MP002294VDW CSB-EP002294VDW-B	Recombinant Vanderwaltozyma polyspora Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Source
CSB-YP002294SXV CSB-EP002294SXV CSB-BP002294SXV CSB-MP002294SXV CSB-EP002294SXV-B	Recombinant Schizosaccharomyces pombe Ubiquitin-like modifier-activating enzyme atg7 (atg7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Komagataella pastoris (Yeast) (Pichia pastoris)

Code	Product Name	Source
CSB-YP002294EVS CSB-EP002294EVS CSB-BP002294EVS CSB-MP002294EVS CSB-EP002294EVS-B	Recombinant Pichia pastoris Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Code	Product Name	Source
CSB-YP685522EKF CSB-EP685522EKF CSB-BP685522EKF CSB-MP685522EKF CSB-EP685522EKF-B	Recombinant Emericella nidulans Ubiquitin-like modifier-activating enzyme atg7 (atg7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)

Code	Product Name	Source
CSB-YP709566MPM CSB-EP709566MPM CSB-BP709566MPM CSB-MP709566MPM CSB-EP709566MPM-B	Recombinant Magnaporthe oryzae Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

Code	Product Name	Source
CSB-YP715315DIS CSB-EP715315DIS CSB-BP715315DIS CSB-MP715315DIS CSB-EP715315DIS-B	Recombinant Debaryomyces hansenii Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

Code	Product Name	Source
CSB-YP715541KBK CSB-EP715541KBK CSB-BP715541KBK CSB-MP715541KBK CSB-EP715541KBK-B	Recombinant Kluyveromyces lactis Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Code	Product Name	Source
CSB-YP718505YAP CSB-EP718505YAP CSB-BP718505YAP CSB-MP718505YAP CSB-EP718505YAP-B	Recombinant Yarrowia lipolytica Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP733556CH CSB-EP733556CH CSB-BP733556CH CSB-MP733556CH CSB-EP733556CH-B	Recombinant Chicken Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP734090RA CSB-EP734090RA CSB-BP734090RA CSB-MP734090RA CSB-EP734090RA-B	Recombinant Rat Ubiquitin-like modifier-activating enzyme ATG7 (Atg7)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

Code	Product Name	Source
CSB-YP738801CZI CSB-EP738801CZI CSB-BP738801CZI CSB-MP738801CZI CSB-EP738801CZI-B	Recombinant Candida glabrata Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

Code	Product Name	Source
CSB-YP765622DOT CSB-EP765622DOT CSB-BP765622DOT CSB-MP765622DOT CSB-EP765622DOT-B	Recombinant Ashbya gossypii Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-YP772976DKK CSB-EP772976DKK CSB-BP772976DKK CSB-MP772976DKK CSB-EP772976DKK-B	Recombinant Dictyostelium discoideum Ubiquitin-like modifier-activating enzyme atg7 (atg7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP842475DOA CSB-EP842475DOA CSB-BP842475DOA CSB-MP842475DOA CSB-EP842475DOA-B	Recombinant Arabidopsis thaliana Ubiquitin-like modifier-activating enzyme atg7 (ATG7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP884031MO CSB-EP884031MO CSB-BP884031MO CSB-MP884031MO CSB-EP884031MO-B	Recombinant Mouse Ubiquitin-like modifier-activating enzyme ATG7 (Atg7)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

atg7 ELISA Kit

atg7 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL002294HU	Human Ubiquitin-like modifier-activating enzyme ATG7(ATG7) ELISA kit	serum, plasma, tissue homogenates, cell lysates	7 pg/mL

atg7 Background

Ubiquitin-like modifier-activating enzyme ATG7 is a protein in humans that is encoded by the ATG7 gene. ATG7 is an E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. It activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. ATG7 is required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. It also modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application