Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
Chromodomain-helicase-DNA-binding protein 8 is a protein in humans that is encoded by CHD8 gene. DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
The following chd8 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
chd8 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005333XA01DIL | chd8 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
chd8 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP005333XBF CSB-EP005333XBF CSB-BP005333XBF CSB-MP005333XBF CSB-EP005333XBF-B |
Recombinant Xenopus tropicalis Chromodomain-helicase-DNA-binding protein 8 (chd8), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
chd8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP005333DIL CSB-EP005333DIL CSB-BP005333DIL CSB-MP005333DIL CSB-EP005333DIL-B |
Recombinant Danio rerio Chromodomain-helicase-DNA-binding protein 8 (chd8), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
chd8 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP872548HU CSB-EP872548HU CSB-BP872548HU CSB-MP872548HU CSB-EP872548HU-B |
Recombinant Human Chromodomain-helicase-DNA-binding protein 8 (CHD8), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
chd8 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP888316RA CSB-EP888316RA CSB-BP888316RA CSB-MP888316RA CSB-EP888316RA-B |
Recombinant Rat Chromodomain-helicase-DNA-binding protein 8 (Chd8), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
