Why are you drunk?

3.Why are others not drunk even they drink much more than you?

The key factor of some people do not get drunk despite of having a lot alcohol is due to ALDH.

A study by the US National Academy of Sciences showed that the amount of alcohol and the presence or absence of alcohol addiction are not developed by the exercise of the day after tomorrow, but by the "drinking gene"-ALDH, which can affect people's response to alcohol.

According to the alcohol metabolism pathway, we know that alcohol is first oxidized to acetaldehyde by ADH, and the content and activity of individual alcohol dehydrogenase are not much different, so this step will not be different in the population. After that, acetaldehyde must be converted to acetic acid under the catalysis of ALDH, and the activity of ALDH in each person varies from person to person, which is the key reason for the difference in alcohol consumption.

People with high ALDH activity have a strong alcohol metabolism capacity; those with low ALDH activity have less ability to metabolize alcohol. The level of ALDH activity is mainly related to heredity, and sometimes it can be induced by alcohol. Long-term drinking boosts the activity of this enzyme, thus increasing the amount of alcohol.

In addition, people who regularly drink large amounts of alcohol have higher MEOS system activity and better metabolism and tolerance to alcohol. This is the scientific evidence that alcohol consumption can be trained.

4.The mechanism of dispelling the effects of alcohol

The general mechanism of the hangover is: stimulate the body to produce acetaldehyde dehydrogenase and increase the enzyme activity, accelerate the oxidation of acetaldehyde to acetic acid, and directly act on the produced acetaldehyde to reduce the toxic effect of acetaldehyde on the body.

5.The cons and pros of drinking


Generally, adults can digest 15 ml of alcohol per hour. Drinking too much alcohol over a long period of time or at one sitting could damage the heart, liver and pancreas, and could elevate the risk of cancer. Long-term drinking also make one person addictive and dependent in alcohol.

Brain: Excess alcohol disturbs one's mind and affects emotions and memory. At the same time, it elevates the risk of stroke and dementia.

Heart: Drinking a lot can damage the heart, leading to heart attacks such as high blood pressure and cardiomyopathy.

Liver: Long-term heavy drinking can cause alcoholic hepatitis and increase the risk of cirrhosis.

Cancer: Head and neck cancer, esophageal cancer, liver cancer, breast cancer, and colorectal cancer also occur frequently in those who prefer to drink.

Acetaldehyde produced during alcohol metabolism is more toxic to humans than ethanol, which is 10 times more toxic than ethanol. Acetaldehyde has great hepatotoxicity, mainly causing changes in liver cells. Alcoholic cirrhosis is the result of the direct action of acetaldehyde on hepatocytes. Acetaldehyde has general anesthetic effects and can also cause drowsiness, paralysis, hallucinations, and loss of intelligence and large doses can even cause death through respiratory paralysis.


Certainly, it is good for the human body to drink wine occasionally. Here list some benefits of drinking little alcohol.

Alcohol categories Benefits
Liquor Smooth blood circulation, scattered blood stasis and blood circulation, phlegm and cold, spleen and warm stomach
Yellow wine Rich in nutrients, contains more than 18 kinds of amino acids, including 8 kinds of essential amino acids
Wine Abundant amino acid and vitamin content; soften blood vessels and protect the heart
Beer "Liquid bread"; promote blood circulation, appetite, protect the heart, help digestion, eliminate fatigue, clearing heat and diuresis

To some extent, alcohol is a good thing. No matter it is wine or beer, they bring us happy moments. However, it is recommended to drink moderately, especially for those who are easily drunk. After all, the vast majority are not Andre the Giant.

Cite this article

CUSABIO team. Why are you drunk?. https://www.cusabio.com/c-20891.html


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