mTOR signaling pathway

The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in multiple cellular functions, such as cell metabolism, proliferation and survival. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, , which regulate different cellular processes. As a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. The mTOR pathway is one of the most studied signaling pathways and is involved in trauma and various diseases in the CNS. mTOR signaling is affected in a number of neurodegenerative conditions, including Alzheimer disease, Parkinson disease, cerebral stroke and Huntington’s disease, and inhibition of mTOR activity can reduce the neurodegeneration associated with these conditions.

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