Nanoparticle Technology Platform
The Nanoparticle technology platform utilizes nanoparticles as carriers for protein expression, offering a wide range of applications and unique features in the field of protein expression. Small molecular weight proteins are challenging to induce immune responses due to their low molecular weight. While fusion with large tags can enhance immune responses, it often leads to structural changes in the target protein, making it difficult to display the correct conformation. Additionally, the majority of the immune response is directed towards the tags rather than the target protein.
CUSABIO has developed a specialized Nanoparticle technology platform based on the HEK293 expression system for small molecular weight protein expression. This platform enhances immune responses while maintaining the correct protein structure and full biological activity.
- Display of natural conformation with full biological activity.
- Enhanced immune responses.
- Suitable for various display library screenings (provides an empty Nanoparticle for counter-screening).
- Applicable for immune assays/ELISA/SPR/BLI/cellular experiments.
The Nanoparticle technology platform offers the following characteristics and advantages:
Efficient protein expression and complete biological activity: The Nanoparticle expression platform utilizes nanoparticles as carriers to effectively transfect and express target proteins. Nanoparticles provide a stable microenvironment that facilitates proper protein folding and expression, thereby presenting native conformations with intact biological activity.
Advantages in expressing small molecular weight proteins: Nanoparticle platform excels in maintaining the conformation of small molecular weight proteins, preserving their linear epitopes and structural motifs. Furthermore, by assembling with coat proteins into nanoparticles, it enhances their immunogenicity.
CUSABIO is committed to providing high-quality recombinant protein products and customized services. The technical advantages of the Nanoparticle technology platform ensure efficient and reliable protein expression. Customized Nanoparticle expression services are available to design and adjust expression strategies according to the protein's characteristics and requirements, guaranteeing efficient protein expression and high-quality results.