TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors!
TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors!TPBG/5T4 has been so appealing recently to pharmaceutical companies as it yields encouraging results in tumor therapies. ClinicalTrial noted that there are over 10 TPBG-targeted drugs in clinical development. Notably, Ox...
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Categories over 10000! --Rare diseases that are no longer
Categories over 10000! --Rare diseases that are no longer "Porcelain doll", "sticky baby" ... behind these seemingly beautiful words is the abyss of pain. It is reported that more than 350 million people in the world are suffering from rare diseases. Statistics show that the pr...
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Mucin-17/MUC17: An Unexpected Target for Tumor Immune Therapy, Notably Gastric Cancer!
Mucin-17/MUC17: An Unexpected Target for Tumor Immune Therapy, Notably Gastric Cancer!Lately, there is robust evidence that mucins play a crucial role in tumor formation, cell adhesion, immune response, and cell signaling. Typically, several mucins have become hot targets for tumor immunotherapy, such as ...
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VSIG4: a Prominent B7 Family Costimulatory Molecule or Complement Receptor in Cancers and Inflammatory Diseases!
VSIG4: a Prominent B7 Family Costimulatory Molecule or Complement Receptor in Cancers and Inflammatory Diseases!On November 28, 2022, Cancer Letters reported a review paper entitled "The biology of VSIG4: Implications for the treatment of immune-mediated inflammatory diseases and cancer", which describes the prominent roles of VSI...
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Epitope Tags Overview
Epitope Tags OverviewIn 1984, S Munro and H R Pelham developed a technique to promote the purification and detection of recombinant proteins, in which an oligonucleotide encoding a peptide was fused to the protein of interest and the target ...
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GPCR Drugs Discovery
GPCR Drugs DiscoveryAs the largest membrane protein family in the known human genome, G protein-coupled receptors (GPCRs) have glittered star proteins, which have been favored by pharmaceutical companies in recent years. GPCR is responsible...
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Monoclonal Antibody Drugs Overview
Monoclonal Antibody Drugs OverviewIn 1982, Humulin (human insulin), the world's first recombinant drug, was approved for marketing. This is a milestone in the development of drug access from chemical synthesis or extraction of Chinese medicine to biotech...
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SLC39A6/ZIP6: a Key Member of Zinc Transporters, a Novel Targeting Antigen of ADC!
SLC39A6/ZIP6: a Key Member of Zinc Transporters, a Novel Targeting Antigen of ADC!Presently, ADC competition heats up in global biotech or pharmaceuticals companies. According to the Pharmsnap database, there are nearly 100 partnered or licensed deals based on ADC new drugs, which has an estimated val...
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What You Have To Know about Lung Cancer
What You Have To Know about Lung CancerLung cancer is the leading cause of cancer deaths in both men and women in the U.S. and worldwide. It claims more lives each year than do colon, prostate, ovarian and breast cancers combined, and the cause of lung cancer...
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TMEFF2: a Tumor-Specific Methylated Biomarker, a Novel Target in Multiple Cancers
TMEFF2: a Tumor-Specific Methylated Biomarker, a Novel Target in Multiple CancersThe European Society for Medical Oncology (ESMO) Congress 2022 was held in Paris, 9-13 September 2022. As the most influential oncology platform for clinicians and researchers globally, the event brings the new opportuni...
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