CD147, a New Target of SARS-CoV-2 InvasionAs of March 25, 2020, SARS-CoV-2 (formally named 2019-nCoV) has raged in more than 40 countries and regions, with a cumulative diagnosis of more than 338,924 people worldwide, and nearly 15,568 deaths. Previously, many s...
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The Application of IHC in Pathological DiagnosisImmunohistochemistry (IHC) is a commonly detection technique in clinical pathological diagnosis. Since the 1970s, immunohistochemical technology has been applied to pathological diagnosis, which has a huge impact on the ...
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ACE2, The Hottest Target of SARS-CoV-2 InvasionA novel coronavirus ( SARS-CoV-2) was identified in Wuhan, Hubei Province, China in December of 2019. The SARS-CoV-2 has resulted in thousands of cases of lethal disease in China, with additional patients being identifie...
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What You Have to Know about Cytokine Storm and Virus InfectionOn January 25, 2020, Prof Bin Cao's team published a research paper titled "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.". The paper revealed that the immune system of critical pati...
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Hematopoietic Stem Cell Surface MarkerHematopoietic stem cells (HSC) are a type of adult stem cells with the characteristics of stem cells: self-renewal and differentiation potential. Hematopoietic stem cells are a kind of pluripotent stem cells...
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Surface Markers of Mesenchymal Stem CellsMesenchymal stem cells (MSCs) are a kind of adult stem cells that exist in various tissues (such as bone marrow, umbilical cord blood and umbilical cord tissue, placental tissue, adipose tissue, etc.) and have multidirec...
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Identify Treg Cells. You Can Do This.The immune system can accurately identify "self" and "non-self", make the body produce protective immune response and realize the monitoring of tumor. Treg cells are regulatory T cells, which are the basic c...
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CD46, A Complement RegulatorCD46 was discovered in 1986 by Cole et al. using C3b affinity chromatography on peripheral blood lymphocytes [1]. CD46, also known as membrane co-protein (MCP), is a membrane protein. The nucleotide sequence of MCP is ho...
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Costimulatory/Coinhibitory: Is B7-H3 An Enemy or A Friend?In cellular immune response, the proliferation and activation of T cells requires not only the first signal presented by APC or MHC on the surface of tumor cells, but also the second signal provided by costimulatory mole...
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PD-1-- An Important Immune CheckpointProgrammed death-1 (PD-1), also known as CD279, is another important negative costimulatory molecule following the discovery of CTLA4. Its ligand is PD-L1, also known as CD274, which, like PD-1, belongs to the CD28/B7 fa...
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