LPS/TLR4 Signal Transduction PathwayIn 1980, Nüsslein-Volhard et al. discovered a gene that determines the dorsal-ventral differentiation in the development of Drosophila embryos and named it Toll [1] [2]. Later, similar homologous receptors were found in...
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What Are the Effects of Abnormalities in the ALK GeneAnaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase of the insulin receptor superfamily. It is highly homologous with leukocyte tyrosine kinase [1]. ALK plays a major role in the...
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These Tumor Databases You Have To KnowCurrently, malignant tumor has become one of the causes of death. The incidence of cancer is increasing globally and the age of onset is getting younger. In 2019, the latest data published by A Cancer Jour...
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Toll-like Receptors--The Eye of Innate ImmunityToll-like receptors (TLRs) is a type I transmembrane protein, can identify different pathogen associated molecular patterns (PAMPs), belongs to the surface of the pattern recognition receptors (PRRs). Toll-like receptors...
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How to Choose the Right Secondary Antibody?Generally speaking, a secondary antibody binds with a primary antibody that is directly attached to the target antigen. In this words, we mention two groups of antibody, one is primary antibody and another is secondary a...
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Effects of FSHR on Fertility and TumorsAs a member of the glycoprotein subfamily of the G protein-coupled receptor superfamily, FSHR participates in signal transduction by binding to ligands. Follicle stimulating hormone (FSH) is a glycoprotein hormone secret...
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The Overview of Recombinant AntibodyAs we all know monoclonal antibodies are secreted by hybridomas in which mouse B cells are fused with myeloma cells, and their murine resistance is inevitable. It is envisioned to create a human antibody that reduces or ...
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Knowledge about TransthyretinTransthyretin (TTR) is also known as vitamin A binding protein, pre-albumin (PA), and thyroid-binding pre-albumin. It is a plasma transporter, mainly synthesized by the liver, that binds and transports thyroxine and reti...
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How to Choose the Loading Control Antibodies?Control antibodies, as the name means, are a series of internal control antibodies. Generally speaking, control antibody can be divided into two groups, including isotype control antibodies and loading control antibodies...
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Tag Antibodies, Your Good Partner in Protein ResearchBefore introducing the tag antibody, let's briefly introduce the protein tag. A protein tag is a protein or polypeptide sequences genetically located at the C or N terminus of a recombinant protein, and the gene sequence...
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