Hematopoietic Stem Cell Surface MarkerHematopoietic stem cells (HSC) are a type of adult stem cells with the characteristics of stem cells: self-renewal and differentiation potential. Hematopoietic stem cells are a kind of pluripotent stem cells...
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Surface Markers of Mesenchymal Stem CellsMesenchymal stem cells (MSCs) are a kind of adult stem cells that exist in various tissues (such as bone marrow, umbilical cord blood and umbilical cord tissue, placental tissue, adipose tissue, etc.) and have multidirec...
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Identify Treg Cells. You Can Do This.The immune system can accurately identify "self" and "non-self", make the body produce protective immune response and realize the monitoring of tumor. Treg cells are regulatory T cells, which are the basic c...
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CD46, A Complement RegulatorCD46 was discovered in 1986 by Cole et al. using C3b affinity chromatography on peripheral blood lymphocytes [1]. CD46, also known as membrane co-protein (MCP), is a membrane protein. The nucleotide sequence of MCP is ho...
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Costimulatory/Coinhibitory: Is B7-H3 An Enemy or A Friend?In cellular immune response, the proliferation and activation of T cells requires not only the first signal presented by APC or MHC on the surface of tumor cells, but also the second signal provided by costimulatory mole...
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PD-1-- An Important Immune CheckpointProgrammed death-1 (PD-1), also known as CD279, is another important negative costimulatory molecule following the discovery of CTLA4. Its ligand is PD-L1, also known as CD274, which, like PD-1, belongs to the CD28/B7 fa...
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CD22- What A Powerful Co-receptor of B Cell ReceptorOn April 23, 2019, Autolus Therapeutics announced that the FDA had granted the AUTO3 drug name. Autolus Therapeutics is a clinical biopharmaceutical company that develops the next generation of programmed T cell therapie...
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Surface Markers of Natural Killer CellsNK cells, also known as natural killer cells, are a type of cytotoxic lymphocyte that is essential for the innate immune system. It was discovered and named in 1975 for its morphological specificity and was developed fro...
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Glial Fibrillary Acidic Protein - Astrocyte Specific MarkerGlial fibrillary acidic protein (GFAP) belongs to class III intermediate filaments (IFs) and is specifically expressed in the cytoplasm of central nervous system astrocytes (AS). It acts as an astrocyte-specific marker. ...
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Homeobox Transcription Factor- NANOGEmbryonic stem cells (ESCs) are stem cells derived from the undifferentiated inner mass cells of a human embryo. Self-renewal and pluripotency are two distinctive characteristics of undifferentiated embryonic stem cells ...
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