A Group of Promising Proteins - Cell Cycle MarkersMost eukaryotic cells depends on an internal clock for survival; they proceed through a sequential event known as the cell cycle . The cell cycle allows multicellular organisms to grow and divide and single-celled or...
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The Oncogene HER2: a New Target for Drug-Resistant TumorsOn March 17, 2021, a research paper entitled "Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors" [1] has attracted attention. Researchers found that the combination of MCL-1 inh...
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NRG1 or NRG1 Fusions: an Intriguing Therapeutic Target in DiseasesOn January 7, 2021, the US FDA has granted a fast track designation to Zenocutuzumab (MCLA-128) as a potential therapeutic option for patients with metastatic solid tumors harboring NRG1 gene fusions. Early, Journal of T...
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TNFR1: A Multifaceted Molecule in Cancer, Another Promising Therapeutic Target for COVID-19On January 7, 2021, a study published in the journal Cancer Research showed that TNFR1-mediated apoptosis and necrosis are associated with leukemia [1]. TNFR1, as an emerging biological target, numerous studies confirm ...
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Neutralizing Antibody Stands Out Among Antiviral TherapiesHuman has been constantly struggling with various diseases from the birth. Human history documented several brutal, disastrous, and deadly diseases, such as smallpox, bubonic plague, cholera, and influenza. They broke ou...
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MUC16 (CA125): a Promising Predictive Marker and Therapeutic Target in CancerOn November 9, 2020, Quest PharmaTech Inc. announced that Oregovomab, a MUC16 monoclonal antibody, has been dosed in the patients with ovarian cancer in phase III clinical trial. It means that targeting MUC16 drugs w...
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ERBB3/HER3: a New Target for Tumor Therapy, a Driver Gene of Multi-TumorsRecently, a study published in the journal Protein & Cell (impact factor: 10.164), attracted attention. The research found that ERBB3 mutation were closely related to tumor tolerance, and further revealed that anti-ERBB3...
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Non-Hodgkin's Lymphoma, One of Common Heterogeneous Malignant TumorsLymphoma is the most common of heterogeneous malignant tumors caused by malignant transformation of lymphocytes. Such tumors usually originate from the lymph nodes or other lymphatic tissues. From the 1970s to the 1990s,...
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Multiple Myeloma, One of High-Risk Factors for COVID-19Accumulating studies have reported that among the people who face the greatest harm from COVID-19 (the disease caused by the SARS-CoV-2) are people with cancer [1]. And among those who have cancer, blood cancers like mul...
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STAT3: a Key Transcriptional Regulator in CancerSignal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor [1]. It is interesting that STAT3 was discovered because of its role in the acute-phase response, which is the only ...
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