IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research!On February 22, 2024, Cell Reports published a significant article titled "Insights into IL-6 Signaling Inhibition with Therapeutic Antibodies." This study highlights how antibodies like Tocilizumab and Sarilumab block t...
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Exploring Protein-Protein Interactions: A Comprehensive Guide to Understanding and Utilizing ItProteins, the executor of life activities, efficiently execute cellular functions through interactions, frequently in the form of protein-protein interactions. Understanding any cellular process requires knowing which pr...
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Interleukin 4 receptor (IL-4R/IL-4Ra): a Multifunctional Target of Cytokines, Suggesting Diverse Potential in Asthma, Rhinitis, Viral, and Tumor Research!On January 26, 2024, a pharmaceutical company license two promising products: an anti-TSLP monoclonal antibody and an anti-IL-4Ra monoclonal antibody. These aim to treat respiratory disorders like asthma and chronic obst...
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In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your ResearchResearchers conduct experiments using various experimental models, which can be categorized into two main types: in vivo and in vitro based on where the research is conducted and the type of biological system being studi...
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Dipeptidase 3 (DPEP3): an Emerging Member of the DPEP Family, a Potential Therapeutic Target in Male Fertility or Tumor Research!On March 15, 2024, the Journal of Affective Disorders published a study delving into the molecular mechanisms of post-traumatic stress disorder (PTSD) and major depression (MDD). The research revealed a notable decrease ...
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CEACAM8: a Member of CEA Family, Emerging as a Vital Player in Gynaecological or Gastrointestinal Cancer Research!In February 2024, the Elsevier database published a article based on bioinformatics analysis. This study identified 42 differentially expressed genes through transcriptomic analysis of multiple sclerosis patients during ...
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CD70 (CD27L/TNFSF7): a TNF Receptor Member, a “Star” Target for Clinical Research in Systemic Lupus Erythematosus (SLE), Arthritis, and Tumors!On January 27, 2024, a study published in the Journal of Autoimmunity explored the impact of CD70 methylation on systemic lupus erythematosus (SLE), revealing elevated levels in SLE patients' CD4+ T cells, potentially li...
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Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research!In January 2024, a research paper titled "Remyelinating effect driven by transferrin-loaded extracellular vesicles" was included in the Scholar database [1]. The study explored using extracellular vesicles (EVs) as carri...
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Myosin Regulatory Light Chains (MYL12A and MYL12B): the New Functional Ligands for CD69, Potential Targets for Cardiac Disease or Tumors Research?Myosin-regulated light chains (MLCs/MRLCs) constitute crucial elements within Myosin II, exerting significant influence on diverse life processes such as muscle contraction and cell division. Recent investigations have u...
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CCR9: A Member of the Chemokine Receptor Family, an Emerging Target for Numerous Tumor Researches!Chemokine receptors, a type of G protein-coupled receptors, are increasingly recognized for their role in various biological processes. They impact normal growth, development, inflammatory responses, immunity, and diseas...
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