ERBB3/HER3: a New Target for Tumor Therapy, a Driver Gene of Multi-Tumors
ERBB3/HER3: a New Target for Tumor Therapy, a Driver Gene of Multi-TumorsRecently, a study published in the journal Protein & Cell (impact factor: 10.164), attracted attention. The research found that ERBB3 mutation were closely related to tumor tolerance, and further revealed that anti-ERBB3...
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Non-Hodgkin's Lymphoma, One of Common Heterogeneous Malignant Tumors
Non-Hodgkin's Lymphoma, One of Common Heterogeneous Malignant TumorsLymphoma is the most common of heterogeneous malignant tumors caused by malignant transformation of lymphocytes. Such tumors usually originate from the lymph nodes or other lymphatic tissues. From the 1970s to the 1990s,...
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Multiple Myeloma, One of High-Risk Factors for COVID-19
Multiple Myeloma, One of High-Risk Factors for COVID-19Accumulating studies have reported that among the people who face the greatest harm from COVID-19 (the disease caused by the SARS-CoV-2) are people with cancer [1]. And among those who have cancer, blood cancers like mul...
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STAT3: a Key Transcriptional Regulator in Cancer
STAT3: a Key Transcriptional Regulator in CancerSignal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor [1]. It is interesting that STAT3 was discovered because of its role in the acute-phase response, which is the only ...
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Melanoma, the Most Serious Type of Skin Cancer
Melanoma, the Most Serious Type of Skin CancerSkin cancer is the most common of all human cancers. In 2020, more than 100,000 people in the U.S. are expected to be diagnosed with some type of the disease. Nearly 7,000 are expected to die. There are three major types...
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Leukemia, Why is it So Common?
Leukemia, Why is it So Common?Upon mentioned leukemia, marrow transplantation and anemia as keywords of leukemia come to your mind. Leukemia is the most common cancer in children and teens, accounting for almost 1 out of 3 cancers. Usually, the numbe...
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Bladder Cancer, A Malignancy that Favors Men
Bladder Cancer, A Malignancy that Favors MenBladder cancer is a common malignancy in women and is the fourth most common malignancy in men [1]. Men's risk is 3-4 times that of women. In 2020, the American Cancer Society estimates that there will have been approxim...
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The Metabolic Phenotype of Tumor-Associated Macrophages in the Tumor Microenvironment
The Metabolic Phenotype of Tumor-Associated Macrophages in the Tumor MicroenvironmentIt is well-recognized that inflammation and immune escape are two hallmarks of tumors. Importantly, tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and bone marrow-derived suppressor cells (MDSC...
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Endometrial Cancer, a Female Killer That is Easily Ignored
Endometrial Cancer, a Female Killer That is Easily IgnoredThe uterus is the hollow, pear-shaped pelvic organ where fetal development occurs. It is very vulnerable to various diseases. Endometrial cancer is one of them, a malignant tumor that occurs in the uterus. It is one of t...
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Osteoprotegerin (OPG): What is Its Potential as a Biomarker or Therapeutic Target?
Osteoprotegerin (OPG): What is Its Potential as a Biomarker or Therapeutic Target?On July 22, 2020, a study published in the journal Cell Death & Differentiation reveals a new regulation mechanism in terms of the osteoprotegerin (OPG). The research implies for the first time that osteoprotegerin (OPG)...
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