Cross-reactivity of Antibody: Beneficial or Harmful?SARS-COV-2, which is ravaging around the world, has been the research hotspot since its breakout in late 2019. At the unremitting efforts of scientific researchers, several types of vaccines against SARS-COV-2 were suc...
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TNFRSF9: A Potent Immune-Stimulator in CancerLast month, a study published on Nature Communications pointed that combining TNFRSF9 agonists with PD-L1 increases anti-tumor activity [1]. In recent years, TNFRSF9 has received much attention as a therapeutic target fo...
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The Overview of One Category of Important Cell Receptors: Receptor Tyrosine KinasesMulticellular organisms live in a complex milieu where signaling pathways play a key role in their survival. As important mediators of this signal cascade, tyrosine kinases exert critical effects in various biological ...
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An Overview of Cell Death: Necrosis and ApoptosisIn every human tissue, new cells are constantly being created while existing cells are constantly dying, so as to keep the total number of cells within the physiologically appropriate range. Cells in the human body hav...
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CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe?On July 4, 2021, an article published in the journal Frontiers in immunology (IF: 7.561) entitled "Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibit...
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NKG2D, a Powerful Molecule Involved In CAR-T And Car-NK Cell TherapyNKG2D, an activated receptor expressed on the surface of human natural killer cells (NKs), CD56+ and CD8+ T cells, plays an important role in innate immunity, participating in the recognition of virus-infected cells and ...
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DNA Damage and RepairDNA is the repository of genetic information that is necessary for an organism to survive and reproduce, so maintaining the integrity of DNA molecules is crucial to cells. However, DNA is inevitably damaged during its co...
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CD20, Why is It Such Popular in Antibody Drug Development?Currently, U.S. Food and Drug Administration (FDA) has approved 27 antibody drugs targeting CD20 in the world, and there are 93 biologics targeting CD20 in the clinical stage of development. Of these clinical projects, t...
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How to Choose? Polyclonal, Monoclonal, or Recombinant Antibody?With the rapid development of life science, researches on protein significantly mount, highlighting the prominent roles of antibodies in experiments. Facing the diverse and complex antibody reagent market, it is particul...
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Does LIF Only Play a Role in Leukaemia?Leukemia inhibitory factor (LIF) is a cytokine which belongs to the IL-6 superfamily. LIF derives its name from its ability to inhibit proliferation of myeloid leukemia cells in culture [1]. As the research of LIF progre...
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