Transmembrane protein series three: G protein-Coupled Receptor

What is G protein-Coupled Receptor?

Transmembrane proteins (TP) is a type of membrane protein that spans one side of the membrane to the other. Transmembrane proteins perform many important cellular biological functions in the body. It is involved in the exchange of matter, energy and signals inside and outside the cell membrane. For example, transmembrane proteins can be receptors for a variety of signaling molecules, hormones, and other substrates, and can activate intra-membrane signaling pathways.

G protein-coupled receptor (GPCR) is a class of transmembrane proteins that detect extracellular molecules and activate internal signal transduction pathways that ultimately activate cellular responses.

G protein-coupled receptors are also known as seven alpha-helices transmembrane segment receptors (7TM receptors). They mediate signals involving visual control, renal function, tumorigenesis, immune response, and inflammation.

Classification of G protein-Coupled Receptor (GPCR)

GPCRs can be divided into six categories based on sequence homology:

Class A: Rhodopsin-like receptor
Class B: Secretin receptor family
Class C: Metabolic glutamate receptor
Class D: Fungal mating pheromone receptor
Class E: Cyclic adenosine receptor
Class F: Frizzled/Smoothened family

Class A accounts for nearly 85% of the GPCR gene and is currently the largest.

In a new classification system, namely GRAFS classification system, GPCR is divided into five categories: glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin).

G protein-Coupled Receptor (GPCR) ligand

The ligand binds to the G-protein-coupled receptor, activates the G-protein, and transmits the signal to the cell, eventually activating the cell reaction. More than 100 ligands are known to achieve transmembrane signaling through G-protein coupled receptors, including: Biogenic amines (epinephrine, norepinephrine, histamine, 5-hydroxytryptamine); Peptide hormones (bradykinin, luteinizing hormone, parathyroid hormone); Odor molecules; photons.

Physiological effects of G protein-Coupled Receptor (GPCR)

Vision: Photosensitive G-protein coupled receptor rhodopsin can converts electromagnetic radiation into cellular signals and initiates downstream signaling processes.

Taste: GPCRs can mediate the release of bitter, umami and sweet substances by gustducin.

Olfactory: Olfactory epithelium in the nasal cavity and olfactory receptors on the vomeronasal can sense odor molecules and pheromones.

Physiological effects of GPCRs also include: behavioral and mood regulation; regulation of the immune system; regulation of the autonomic nervous system; detection and regulation of cell density.

G protein-Coupled Receptor (GPCR)and drug development

Major human diseases such as cancer, AIDS, heart disease, diabetes, Alzheimer's disease, Parkinson's disease, dwarfism, dwarfism, color blindness, retinitis pigmentosa and asthma are closely related to GPCRs. Therefore, GPCR is also a "star" in the field of drug development.

Currently, about 40% of marketed drugs are designed based on GPCRs. At least one-third of small molecule drugs in the world's pharmaceutical market are currently activators or antagonists of GPCRs. Twenty percent of the top 50 best-selling drugs currently on the market are reportedly G-receptor-related drugs.

For more details about GPCRs, for example, the structure, history, etc., please read the article: G protein-Coupled Receptor - Targets for Drug Therapy.

The important role of GPCR in the drug target protein determines its importance in the life sciences. CUSABIO can provide the products you need for your research. Currently, we could product 183 GPCR-related products: 70 protein products, 89 antibody products, 24 ELISA products.

Hot Products

G protein-Coupled Receptor (GPCR) related proteins for your research

Target Product Name Code Expression System
ACKR1 Recombinant Human Atypical chemokine receptor 1(ACKR1) CSB-CF624105HU in vitro E.coli expression system
ACKR2 Recombinant Human Atypical chemokine receptor 2(ACKR2) CSB-CF004618HU in vitro E.coli expression system
ACKR3 Recombinant Human Atypical chemokine receptor 3(ACKR3) CSB-CF006257HU in vitro E.coli expression system
ACKR4 Recombinant Human Atypical chemokine receptor 4(ACKR4) CSB-CF865095HU in vitro E.coli expression system
ADRB2 Recombinant Human Beta-2 adrenergic receptor(ADRB2) CSB-CF001392HU in vitro E.coli expression system
Agtr2 Recombinant Rat Type-2 angiotensin II receptor(Agtr2) ,partial CSB-EP001466RA E.coli
C5AR2 Recombinant Human C5a anaphylatoxin chemotactic receptor 2(C5AR2) CSB-CF868390HU in vitro E.coli expression system
CCR1 Recombinant Human C-C chemokine receptor type 1(CCR1) CSB-CF004839HU in vitro E.coli expression system
CCR10 Recombinant Human C-C chemokine receptor type 10(CCR10) CSB-CF004840HU in vitro E.coli expression system
CCR2 Recombinant Human C-C chemokine receptor type 2(CCR2) CSB-CF004841HU in vitro E.coli expression system
CCR3 Recombinant Human C-C chemokine receptor type 3(CCR3) CSB-CF004842HU in vitro E.coli expression system
CCR4 Recombinant Human C-C chemokine receptor type 4(CCR4) CSB-CF004843HU in vitro E.coli expression system
CCR5 Recombinant Human C-C chemokine receptor type 5(CCR5) CSB-CF004844HU in vitro E.coli expression system
CCR6 Recombinant Human C-C chemokine receptor type 6(CCR6) CSB-CF004845HU in vitro E.coli expression system
CCR7 Recombinant Human C-C chemokine receptor type 7(CCR7) CSB-CF004846HU in vitro E.coli expression system
CCR8 Recombinant Human C-C chemokine receptor type 8(CCR8) CSB-CF004847HU in vitro E.coli expression system
CCR9 Recombinant Human C-C chemokine receptor type 9(CCR9) CSB-CF004848HU in vitro E.coli expression system
CCRL2 Recombinant Human C-C chemokine receptor-like 2(CCRL2) CSB-CF004852HU in vitro E.coli expression system
CREB1 Recombinant Human Cyclic AMP-responsive element-binding protein 1(CREB1) CSB-EP005947HU E.coli
CRHR1 Recombinant Human Corticotropin-releasing factor receptor 1(CRHR1),partial CSB-EP005965HU E.coli
CX3CR1 Recombinant Human CX3C chemokine receptor 1(CX3CR1) CSB-CF006236HU in vitro E.coli expression system
CXCR1 Recombinant Human C-X-C chemokine receptor type 1(CXCR1) CSB-CF011672HU in vitro E.coli expression system
CXCR2 Recombinant Human C-X-C chemokine receptor type 2(CXCR2) CSB-CF011673HU in vitro E.coli expression system
CXCR3 Recombinant Human C-X-C chemokine receptor type 3(CXCR3) CSB-CF006253HU in vitro E.coli expression system
CXCR4 Recombinant Human C-X-C chemokine receptor type 4(CXCR4) CSB-CF006254HU in vitro E.coli expression system
CXCR5 Recombinant Human C-X-C chemokine receptor type 5(CXCR5) CSB-CF006255HU in vitro E.coli expression system
CXCR6 Recombinant Human C-X-C chemokine receptor type 6(CXCR6) CSB-CF006256HU in vitro E.coli expression system
DGKE Recombinant Human Diacylglycerol kinase epsilon(DGKE) CSB-CF006835HU in vitro E.coli expression system
EDNRA Recombinant Human Endothelin-1 receptor(EDNRA) CSB-CF007403HU in vitro E.coli expression system
FPR1 Recombinant Human fMet-Leu-Phe receptor(FPR1),partial CSB-EP008854HU1d1 E.coli
Fpr2 Recombinant Mouse Formyl peptide receptor 2(Fpr2),partial CSB-EP008855MO1 E.coli
FSHR Recombinant Human Follicle-stimulating hormone receptor(FSHR),partial CSB-EP009021HU E.coli
Gcgr Recombinant Mouse Glucagon receptor(Gcgr),partial CSB-EP009316MO E.coli
GLP1R Recombinant Human Glucagon-like peptide 1 receptor(GLP1R) CSB-CF009514HU(A4) in vitro E.coli expression system
GNAI3 Recombinant Human Guanine nucleotide-binding protein G(k) subunit alpha(GNAI3) CSB-EP009591HU E.coli
GNAZ Recombinant Human Guanine nucleotide-binding protein G(z) subunit alpha(GNAZ) CSB-EP009601HU E.coli
GPR157 Recombinant Human G-protein coupled receptor 157(GPR157) CSB-CF713185HU in vitro E.coli expression system
HCRTR1 Recombinant Human Orexin receptor type 1(HCRTR1) CSB-YP010231HU1 Yeast
HTR1F Recombinant Human 5-hydroxytryptamine receptor 1F(HTR1F) CSB-CF010886HU in vitro E.coli expression system
HTR2B Recombinant Human 5-hydroxytryptamine receptor 2B(HTR2B) CSB-CF010888HU in vitro E.coli expression system
HTR7 Recombinant Human 5-hydroxytryptamine receptor 7(HTR7) CSB-CF010899HU in vitro E.coli expression system
LGR5 Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5(LGR5),partial CSB-EP012906HU E.coli
NPFFR2 Recombinant Human Neuropeptide FF receptor 2(NPFFR2) CSB-YP015983HU Yeast
OR1A1 Recombinant Human Olfactory receptor 1A1(OR1A1) CSB-CF865201HU in vitro E.coli expression system
P2RY12 Recombinant Human P2Y purinoceptor 12(P2RY12) CSB-CF861997HU in vitro E.coli expression system
XCR1 Recombinant Human Chemokine XC receptor 1(XCR1) CSB-CF026188HU in vitro E.coli expression system

G protein-Coupled Receptor (GPCR) related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
ACKR1 ACKR1 Antibody CSB-PA006504GA01HU Human, Mouse, Rat ELISA, WB
ADGRE1 EMR1 Antibody CSB-PA007651GA01HU Human, Mouse, Rat ELISA, WB
ADORA1 ADORA1 Antibody CSB-PA001375GA01HU Human, Mouse, Rat ELISA, WB
ADRA1A ADRA1A Antibody CSB-PA001385GA01HU Human, Mouse, Rat ELISA, WB
ADRB2 ADRB2 Antibody CSB-PA001392GA01HU Human, Mouse, Rat ELISA, WB, IHC
ARRB1 ARRB1 Antibody CSB-PA002134GA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
C1QTNF1 C1QTNF1 Antibody CSB-PA003646GA01HU Human, Mouse, Rat ELISA, WB, IHC
C5AR1 C5AR1 Antibody CSB-PA003996GA01HU Human, Mouse, Rat ELISA, WB, IF
CASR CASR Antibody CSB-PA004558GA01HU Human, Mouse, Rat ELISA, WB
CCR5 CCR5 Antibody CSB-PA004844GA01HU Human, Mouse, Rat ELISA, WB
CNR1 CNR1 Antibody CSB-PA005678GA01HU Human, Mouse, Rat ELISA, WB
CREB1 CREB1 Antibody CSB-PA005947GA01HU Human, Mouse, Rat ELISA, WB
CRY1 CRY1 Antibody CSB-PA006005GA01HU Human, Mouse, Rat ELISA, WB, IF
CX3CR1 CX3CR1 Antibody CSB-PA006236GA01HU Human, Mouse, Rat ELISA, WB
CXCR4 CXCR4 Antibody CSB-PA006254GA01HU Human, Mouse, Rat ELISA, WB
DRD1 DRD1 Antibody CSB-PA007178GA01HU Human, Mouse, Rat ELISA, WB
F2RL1 F2RL1 Antibody CSB-PA007925GA01HU Human, Mouse, Rat ELISA, WB
FZD9 FZD9 Antibody CSB-PA009112GA01HU Human, Mouse, Rat ELISA, WB
GABBR1 GABBR1 Antibody CSB-PA009134GA01HU Human, Mouse, Rat ELISA, WB
GGA2 GGA2 Antibody CSB-PA009385GA01HU Human, Mouse, Rat ELISA, WB
GNA13 GNA13 Antibody CSB-PA009585GA01HU Human, Mouse, Rat ELISA, WB
GNAI1 GNAI1 Antibody CSB-PA009588GA01HU Human, Mouse, Rat ELISA, WB, IHC
GPR17 GPR17 Antibody CSB-PA009778GA01HU Human, Mouse, Rat ELISA, WB
GPR22 GPR22 Antibody CSB-PA009796GA01HU Human, Mouse, Rat ELISA, WB
GPR37 GPR37 Antibody CSB-PA009810GA01HU Human, Mouse, Rat ELISA, WB
GRK2 ADRBK1 Antibody CSB-PA001394GA01HU Human, Mouse, Rat ELISA, WB, IHC
GRM1 GRM1 Antibody CSB-PA009931GA01HU Human, Mouse, Rat ELISA, WB
HCRTR1 HCRTR1 Antibody CSB-PA010231GA01HU Human, Mouse, Rat ELISA, WB
HRH1 HRH1 Antibody CSB-PA010737GA01HU Human, Mouse, Rat ELISA, WB, IHC
LGR6 LGR6 Antibody CSB-PA012907GA01HU Human, Mouse, Rat ELISA, WB, IHC
LHCGR LHCGR Antibody CSB-PA012911GA01HU Human, Mouse, Rat ELISA, WB, IHC
LPAR3 LPAR3 Antibody CSB-PA013049GA01HU Human, Mouse, Rat ELISA, WB
MCHR1 MCHR1 Antibody CSB-PA013584GA01HU Human, Mouse, Rat ELISA, WB
OPRL1 OPRL1 Antibody CSB-PA016360GA01HU Human, Mouse, Rat ELISA, WB, IHC
P2RY1 P2RY1 Antibody CSB-PA017326GA01HU Human, Mouse, Rat ELISA, WB, IHC
P2RY6 P2RY6 Antibody CSB-PA017337GA01HU Human, Mouse, Rat ELISA, WB
PRKAR1A PRKAR1A Antibody CSB-PA018694GA01HU Human, Mouse, Rat ELISA, WB
PTGER3 PTGER3 Antibody CSB-PA018972GA01HU Human, Mouse, Rat ELISA, WB
PTH2R PTH2R Antibody CSB-PA018990GA01HU Human, Mouse, Rat ELISA, WB, IHC
PTK2 PTK2 Antibody CSB-PA018993GA01HU Human, Mouse, Rat ELISA, WB, IHC
PTK2B PTK2B Antibody CSB-PA018994GA01HU Human, Mouse, Rat ELISA, WB, IHC
RGR RGR Antibody CSB-PA019640GA01HU Human, Mouse, Rat ELISA, WB, IHC
S1PR1 S1PR1 Antibody CSB-PA020650GA01HU Human, Mouse, Rat ELISA, WB
SCTR SCTR Antibody CSB-PA020865GA01HU Human, Mouse, Rat ELISA, WB
SH3GL2 SH3GL2 Antibody CSB-PA021231GA01HU Human, Mouse, Rat ELISA, WB, IHC
SSTR1 SSTR1 Antibody CSB-PA022724GA01HU Human, Mouse, Rat ELISA, WB
TACR1 TACR1 Antibody CSB-PA023068GA01HU Human, Mouse, Rat ELISA, WB
USP20 USP20 Antibody CSB-PA025711GA01HU Human, Mouse, Rat ELISA, WB, IHC
USP33 USP33 Antibody CSB-PA025724GA01HU Human, Mouse, Rat ELISA, WB, IHC

G protein-Coupled Receptor (GPCR) related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
ADORA1 Mouse Adenosine receptor A1(ADORA1) ELISA kit CSB-EL001375MO serum, plasma, tissue homogenates, cell lysates 9.75 pg/mL
ADORA2A Mouse Adenosine receptor A2a(ADORA2A) ELISA kit CSB-EL001376MO serum, plasma, tissue homogenates, cell lysates 7.81 pg/mL
ADORA2B Mouse Adenosine receptor A2b(ADORA2B) ELISA kit CSB-EL001377MO serum, plasma, tissue homogenates, cell culture supernates 7.81 pg/mL
ADRB1 Human Beta-1 adrenergic receptor(ADRB1) ELISA kit CSB-EL001391HU serum, plasma, tissue homogenates, cell lysates 6.25 pg/mL
ADRB2 Human Beta-2 adrenergic receptor(ADRB2) ELISA kit CSB-EL001392HU serum, plasma, tissue homogenates, cell lysates 4.69 pg/mL
ADRB2 Mouse Beta-2 adrenergic receptor(ADRB2) ELISA kit CSB-EL001392MO serum, plasma, tissue homogenates 4.69 pg/mL
ADRBK1 Human Beta-adrenergic receptor kinase 1(ADRBK1) ELISA kit CSB-EL001394HU serum, plasma, tissue homogenates, cell lysates 4.68 pg/mL
AGTR1 Human angiotensin Ⅱ receptor 1,ANGⅡR-1 ELISA Kit CSB-E11239h serum, plasma, tissue homogenates, cell lysates 11.72 pg/mL
AGTR1 Rat angiotensin Ⅱ receptor type 1(AT1R)ELISA Kit CSB-E13746r serum, plasma, tissue homogenates 19.5 pg/mL
APLNR Human Apelin receptor(APLNR) ELISA kit CSB-EL001910HU serum, plasma, tissue homogenates, cell lysates 5.8 pg/mL
ARRB2 Rat Beta-arrestin-2(ARRB2) ELISA kit CSB-EL002135RA serum, plasma, tissue homogenates, cell lysates 11.72 pg/mL
BDKRB1 Human B1 bradykinin receptor(BDKRB1) ELISA kit CSB-EL002651HU serum, plasma, tissue homogenates, cell lysates 6.25 pg/mL
C1QTNF1 Human Complement C1q tumor necrosis factor-related protein 1(C1QTNF1/CTRP1) ELISA Kit CSB-E16713h serum, plasma, tissue homogenates 0.078 ng/mL
C3AR1 Human C3a anaphylatoxin chemotactic receptor(C3AR1) ELISA kit CSB-EL003889HU serum, plasma, tissue homogenates, cell lysates 6.25 pg/mL
CCR1 Human CC-chemokine receptor 1,CCR1 ELISA Kit CSB-E09953h serum, plasma, tissue homogenates, cell lysates 9.77 pg/mL
CCR2 Human CC-Chemokine Receptor 2,CCR2 ELISA Kit CSB-E14200h serum, plasma, tissue homogenates, cerebrospinal fluid (CSF) 5.86 pg/mL
CCR2 Mouse C-C chemokine receptor type 2(CCR2) ELISA kit CSB-EL004841MO serum, plasma, tissue homogenates 3.9 pg/mL
CCR2 Rat C-C chemokine receptor type 2(CCR2) ELISA kit CSB-EL004841RA serum, plasma, tissue homogenates 3.9 pg/mL
CCR6 Human C-C chemokine receptor type 6(CCR6) ELISA kit CSB-EL004845HU serum, plasma, cell culture supernates, tissue homogenetes 0.78 pg/mL
CCR7 Human C-C Chemokine receptor 7,CCR-7 ELISA Kit CSB-E11293h serum, plasma, tissue homogenates, cell lysates 4.68 pg/mL
CHRM1 Rat Muscarinic acetylcholine receptor M1(CHRM1) ELISA kit CSB-EL005381RA serum, plasma, tissue homogenates, cell lysates 3.9 pg/mL
CHRM3 Human Muscarinic acetylcholine receptor M3(CHRM3) ELISA kit CSB-EL005383HU serum, plasma, tissue homogenates 5.86 pg/mL
CHRM3 Rat Muscarinic acetylcholine receptor M3(CHRM3) ELISA kit CSB-EL005383RA serum, plasma, tissue homogenates, cell lysates 0.039 ng/mL
CHRM4 Rat Muscarinic acetylcholine receptor M4(CHRM4) ELISA kit CSB-EL005384RA serum, plasma, tissue homogenates, cell lysates 7.8 pg/mL

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