CD47|Proteinase K|EGFR|BCMA|PD-L1|CD276|ACE2|TMPRSS2|Exosome Isolation Kits
Transmembrane proteins (TP) is a type of membrane protein that spans one side of the membrane to the other. Transmembrane proteins perform many important cellular biological functions in the body. It is involved in the exchange of matter, energy and signals inside and outside the cell membrane. For example, transmembrane proteins can be receptors for a variety of signaling molecules, hormones, and other substrates, and can activate intra-membrane signaling pathways.
G protein-coupled receptor (GPCR) is a class of transmembrane proteins that detect extracellular molecules and activate internal signal transduction pathways that ultimately activate cellular responses.
G protein-coupled receptors are also known as seven alpha-helices transmembrane segment receptors (7TM receptors). They mediate signals involving visual control, renal function, tumorigenesis, immune response, and inflammation.
GPCRs can be divided into six categories based on sequence homology:
Class A: Rhodopsin-like receptor
Class B: Secretin receptor family
Class C: Metabolic glutamate receptor
Class D: Fungal mating pheromone receptor
Class E: Cyclic adenosine receptor
Class F: Frizzled/Smoothened family
Class A accounts for nearly 85% of the GPCR gene and is currently the largest.
In a new classification system, namely GRAFS classification system, GPCR is divided into five categories: glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin).
The ligand binds to the G-protein-coupled receptor, activates the G-protein, and transmits the signal to the cell, eventually activating the cell reaction. More than 100 ligands are known to achieve transmembrane signaling through G-protein coupled receptors, including: Biogenic amines (epinephrine, norepinephrine, histamine, 5-hydroxytryptamine); Peptide hormones (bradykinin, luteinizing hormone, parathyroid hormone); Odor molecules; photons.
Vision: Photosensitive G-protein coupled receptor rhodopsin can converts electromagnetic radiation into cellular signals and initiates downstream signaling processes.
Taste: GPCRs can mediate the release of bitter, umami and sweet substances by gustducin.
Olfactory: Olfactory epithelium in the nasal cavity and olfactory receptors on the vomeronasal can sense odor molecules and pheromones.
Physiological effects of GPCRs also include: behavioral and mood regulation; regulation of the immune system; regulation of the autonomic nervous system; detection and regulation of cell density.
Major human diseases such as cancer, AIDS, heart disease, diabetes, Alzheimer's disease, Parkinson's disease, dwarfism, dwarfism, color blindness, retinitis pigmentosa and asthma are closely related to GPCRs. Therefore, GPCR is also a "star" in the field of drug development.
Currently, about 40% of marketed drugs are designed based on GPCRs. At least one-third of small molecule drugs in the world's pharmaceutical market are currently activators or antagonists of GPCRs. Twenty percent of the top 50 best-selling drugs currently on the market are reportedly G-receptor-related drugs.
For more details about GPCRs, for example, the structure, history, etc., please read the article: G protein-Coupled Receptor - Targets for Drug Therapy.
The important role of GPCR in the drug target protein determines its importance in the life sciences. CUSABIO can provide the products you need for your research. Currently, we could product 183 GPCR-related products: 70 protein products, 89 antibody products, 24 ELISA products.
Hot Products
Recombinant Human Atypical chemokine receptor 2(ACKR2) (CSB-CF004618HU)
Recombinant Human C-C chemokine receptor type 2(CCR2) (CSB-CF004841HU)
Target | Product Name | Code | Species Reactivity | Tested Applications |
---|---|---|---|---|
ACKR1 | ACKR1 Antibody | CSB-PA006504GA01HU | Human, Mouse, Rat | ELISA, WB |
ADGRE1 | EMR1 Antibody | CSB-PA007651GA01HU | Human, Mouse, Rat | ELISA, WB |
ADORA1 | ADORA1 Antibody | CSB-PA001375GA01HU | Human, Mouse, Rat | ELISA, WB |
ADRA1A | ADRA1A Antibody | CSB-PA001385GA01HU | Human, Mouse, Rat | ELISA, WB |
ADRB2 | ADRB2 Antibody | CSB-PA001392GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
ARRB1 | ARRB1 Antibody | CSB-PA002134GA01HU | Human, Mouse, Rat | ELISA, WB, IHC, IF |
C1QTNF1 | C1QTNF1 Antibody | CSB-PA003646GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
C5AR1 | C5AR1 Antibody | CSB-PA003996GA01HU | Human, Mouse, Rat | ELISA, WB, IF |
CASR | CASR Antibody | CSB-PA004558GA01HU | Human, Mouse, Rat | ELISA, WB |
CCR5 | CCR5 Antibody | CSB-PA004844GA01HU | Human, Mouse, Rat | ELISA, WB |
CNR1 | CNR1 Antibody | CSB-PA005678GA01HU | Human, Mouse, Rat | ELISA, WB |
CREB1 | CREB1 Antibody | CSB-PA005947GA01HU | Human, Mouse, Rat | ELISA, WB |
CRY1 | CRY1 Antibody | CSB-PA006005GA01HU | Human, Mouse, Rat | ELISA, WB, IF |
CX3CR1 | CX3CR1 Antibody | CSB-PA006236GA01HU | Human, Mouse, Rat | ELISA, WB |
CXCR4 | CXCR4 Antibody | CSB-PA006254GA01HU | Human, Mouse, Rat | ELISA, WB |
DRD1 | DRD1 Antibody | CSB-PA007178GA01HU | Human, Mouse, Rat | ELISA, WB |
F2RL1 | F2RL1 Antibody | CSB-PA007925GA01HU | Human, Mouse, Rat | ELISA, WB |
FZD9 | FZD9 Antibody | CSB-PA009112GA01HU | Human, Mouse, Rat | ELISA, WB |
GABBR1 | GABBR1 Antibody | CSB-PA009134GA01HU | Human, Mouse, Rat | ELISA, WB |
GGA2 | GGA2 Antibody | CSB-PA009385GA01HU | Human, Mouse, Rat | ELISA, WB |
GNA13 | GNA13 Antibody | CSB-PA009585GA01HU | Human, Mouse, Rat | ELISA, WB |
GNAI1 | GNAI1 Antibody | CSB-PA009588GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
GPR17 | GPR17 Antibody | CSB-PA009778GA01HU | Human, Mouse, Rat | ELISA, WB |
GPR22 | GPR22 Antibody | CSB-PA009796GA01HU | Human, Mouse, Rat | ELISA, WB |
GPR37 | GPR37 Antibody | CSB-PA009810GA01HU | Human, Mouse, Rat | ELISA, WB |
GRK2 | ADRBK1 Antibody | CSB-PA001394GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
GRM1 | GRM1 Antibody | CSB-PA009931GA01HU | Human, Mouse, Rat | ELISA, WB |
HCRTR1 | HCRTR1 Antibody | CSB-PA010231GA01HU | Human, Mouse, Rat | ELISA, WB |
HRH1 | HRH1 Antibody | CSB-PA010737GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
LGR6 | LGR6 Antibody | CSB-PA012907GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
LHCGR | LHCGR Antibody | CSB-PA012911GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
LPAR3 | LPAR3 Antibody | CSB-PA013049GA01HU | Human, Mouse, Rat | ELISA, WB |
MCHR1 | MCHR1 Antibody | CSB-PA013584GA01HU | Human, Mouse, Rat | ELISA, WB |
OPRL1 | OPRL1 Antibody | CSB-PA016360GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
P2RY1 | P2RY1 Antibody | CSB-PA017326GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
P2RY6 | P2RY6 Antibody | CSB-PA017337GA01HU | Human, Mouse, Rat | ELISA, WB |
PRKAR1A | PRKAR1A Antibody | CSB-PA018694GA01HU | Human, Mouse, Rat | ELISA, WB |
PTGER3 | PTGER3 Antibody | CSB-PA018972GA01HU | Human, Mouse, Rat | ELISA, WB |
PTH2R | PTH2R Antibody | CSB-PA018990GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
PTK2 | PTK2 Antibody | CSB-PA018993GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
PTK2B | PTK2B Antibody | CSB-PA018994GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
RGR | RGR Antibody | CSB-PA019640GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
S1PR1 | S1PR1 Antibody | CSB-PA020650GA01HU | Human, Mouse, Rat | ELISA, WB |
SCTR | SCTR Antibody | CSB-PA020865GA01HU | Human, Mouse, Rat | ELISA, WB |
SH3GL2 | SH3GL2 Antibody | CSB-PA021231GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
SSTR1 | SSTR1 Antibody | CSB-PA022724GA01HU | Human, Mouse, Rat | ELISA, WB |
TACR1 | TACR1 Antibody | CSB-PA023068GA01HU | Human, Mouse, Rat | ELISA, WB |
USP20 | USP20 Antibody | CSB-PA025711GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
USP33 | USP33 Antibody | CSB-PA025724GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
Target | Product Name | Code | Sample Type | Sensitivity |
---|---|---|---|---|
ADORA1 | Mouse Adenosine receptor A1(ADORA1) ELISA kit | CSB-EL001375MO | serum, plasma, tissue homogenates, cell lysates | 9.75 pg/mL |
ADORA2A | Mouse Adenosine receptor A2a(ADORA2A) ELISA kit | CSB-EL001376MO | serum, plasma, tissue homogenates, cell lysates | 7.81 pg/mL |
ADORA2B | Mouse Adenosine receptor A2b(ADORA2B) ELISA kit | CSB-EL001377MO | serum, plasma, tissue homogenates, cell culture supernates | 7.81 pg/mL |
ADRB1 | Human Beta-1 adrenergic receptor(ADRB1) ELISA kit | CSB-EL001391HU | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
ADRB2 | Human Beta-2 adrenergic receptor(ADRB2) ELISA kit | CSB-EL001392HU | serum, plasma, tissue homogenates, cell lysates | 4.69 pg/mL |
ADRB2 | Mouse Beta-2 adrenergic receptor(ADRB2) ELISA kit | CSB-EL001392MO | serum, plasma, tissue homogenates | 4.69 pg/mL |
ADRBK1 | Human Beta-adrenergic receptor kinase 1(ADRBK1) ELISA kit | CSB-EL001394HU | serum, plasma, tissue homogenates, cell lysates | 4.68 pg/mL |
AGTR1 | Human angiotensin Ⅱ receptor 1,ANGⅡR-1 ELISA Kit | CSB-E11239h | serum, plasma, tissue homogenates, cell lysates | 11.72 pg/mL |
AGTR1 | Rat angiotensin Ⅱ receptor type 1(AT1R)ELISA Kit | CSB-E13746r | serum, plasma, tissue homogenates | 19.5 pg/mL |
APLNR | Human Apelin receptor(APLNR) ELISA kit | CSB-EL001910HU | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
ARRB2 | Rat Beta-arrestin-2(ARRB2) ELISA kit | CSB-EL002135RA | serum, plasma, tissue homogenates, cell lysates | 11.72 pg/mL |
BDKRB1 | Human B1 bradykinin receptor(BDKRB1) ELISA kit | CSB-EL002651HU | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
C1QTNF1 | Human Complement C1q tumor necrosis factor-related protein 1(C1QTNF1/CTRP1) ELISA Kit | CSB-E16713h | serum, plasma, tissue homogenates | 0.078 ng/mL |
C3AR1 | Human C3a anaphylatoxin chemotactic receptor(C3AR1) ELISA kit | CSB-EL003889HU | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
CCR1 | Human CC-chemokine receptor 1,CCR1 ELISA Kit | CSB-E09953h | serum, plasma, tissue homogenates, cell lysates | 9.77 pg/mL |
CCR2 | Human CC-Chemokine Receptor 2,CCR2 ELISA Kit | CSB-E14200h | serum, plasma, tissue homogenates, cerebrospinal fluid (CSF) | 5.86 pg/mL |
CCR2 | Mouse C-C chemokine receptor type 2(CCR2) ELISA kit | CSB-EL004841MO | serum, plasma, tissue homogenates | 3.9 pg/mL |
CCR2 | Rat C-C chemokine receptor type 2(CCR2) ELISA kit | CSB-EL004841RA | serum, plasma, tissue homogenates | 3.9 pg/mL |
CCR6 | Human C-C chemokine receptor type 6(CCR6) ELISA kit | CSB-EL004845HU | serum, plasma, cell culture supernates, tissue homogenetes | 0.78 pg/mL |
CCR7 | Human C-C Chemokine receptor 7,CCR-7 ELISA Kit | CSB-E11293h | serum, plasma, tissue homogenates, cell lysates | 4.68 pg/mL |
CHRM1 | Rat Muscarinic acetylcholine receptor M1(CHRM1) ELISA kit | CSB-EL005381RA | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
CHRM3 | Human Muscarinic acetylcholine receptor M3(CHRM3) ELISA kit | CSB-EL005383HU | serum, plasma, tissue homogenates | 5.86 pg/mL |
CHRM3 | Rat Muscarinic acetylcholine receptor M3(CHRM3) ELISA kit | CSB-EL005383RA | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
CHRM4 | Rat Muscarinic acetylcholine receptor M4(CHRM4) ELISA kit | CSB-EL005384RA | serum, plasma, tissue homogenates, cell lysates | 7.8 pg/mL |