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Monkey Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit

Protocol
Code CSB-EL017647RH
Size 96T,5×96T,10×96T
Price Request a Quote
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Product Details

Alternative Names
PCSK9 ELISA Kit; Proprotein convertase subtilisin/kexin type 9 ELISA Kit; EC 3.4.21.- ELISA Kit; Proprotein convertase 9 ELISA Kit; PC9 ELISA Kit; Subtilisin/kexin-like protease PC9 ELISA Kit
Abbreviation
PCSK9
Uniprot No.
A8T666
Species
Monkey
Sample Types
serum, plasma, tissue homogenates
Detection Range
0.47 ng/mL-15 ng/mL
Sensitivity
0.235 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Metabolism
Assay Principle
quantitative
Measurement
Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess. 
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
 
Typical Data

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 

ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Shelf Life
6 months
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Description

This Monkey PCSK9 ELISA Kit was designed for the quantitative measurement of Monkey PCSK9 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 1.1 pg/mL-800 pg/mL and the sensitivity is 1.1 pg/mL.

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PCSK9 Proteins

Customer Reviews and Q&A

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Target Background

Function
(From Uniprot)
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
Subcellular Location
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus.
Protein Families
Peptidase S8 family
Database Links

KEGG: mcc:717147

UniGene: Mmu.17333

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Related pathways
Cholesterol metabolism
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