Name: Human Integrin beta-8(ITGB8) ELISA kit
Brand: CUSABIO
SKU: CSB-EL011892HU

Product Details

Target Name

integrin, beta 8

Alternative Names

ITGB8; Integrin beta-8

Abbreviation

ITGB8

Uniprot No.

P26012

Species

Homo sapiens (Human)

Sample Types

serum, plasma,tissue homogenates

Detection Range

0.39 ng/mL-25 ng/mL

Sensitivity

0.09 ng/mL

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Signal Transduction

Assay Principle

quantitative

Measurement

Sandwich

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

Description

This Human ITGB8 ELISA Kit was designed for the quantitative measurement of Human ITGB8 protein in serum, plasma,tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.39 ng/mL-25 ng/mL and the sensitivity is 0.09 ng/mL.

Customer Reviews and Q&A

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■ Q&A

Could you please confirm for me whether the standard used in your kit for human ITG8 is just the beta 8 subunit or it is a heterodimer with alpha subunit?
Normally integrin 8 exists as a heterodimer with alpha v subunit and wanted to check whether the standard in your kit contains just b8?

Thanks for your inquiry!The standatd of csb-el011892hu is 293 cell-derived recombinant human Integrin beta-8 protein)(contains just b8).

Target Background

Function
(From Uniprot)

Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis.

Gene References into Functions

ITGB8 is identified as a novel target of miR-26a-5p. PMID: 29746867
our results indicate that miR-199a-3p enhances cisplatinsensitivity of ovarian cancer cells through downregulating ITGB8 expression, and miR-199a-3p may serve as a therapeutic target for the treatment of ovarian cancer patients with cisplatin-resistance. PMID: 29436681
In cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. PMID: 29204818
Among Greek and Polish patients with intracerebral hemorrhage, heterozygous individuals with the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes. PMID: 27476161
The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma. PMID: 29337055
Integrin beta8 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
Integrin Beta8 plays a role in the motility of prostate cancer cells. PMID: 25886373
data show that integrin beta 8, but not integrin beta 5 or integrin beta 6, protein expression is increased in liver specimens of patients with biliary atresia PMID: 25079481
Brain metastases ITGB8 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
Desmoglein-2 co-localizes with integrin-beta8 in N-MVECs. PMID: 23874518
ITGB8 silencing may change lung cancer cells to a less invasive phenotype through alteration in the expression of metastasis-related genes. PMID: 22753015
Deletion of the Itgb8 gene from retinal ganglia cells and Mu ller glia, but not astrocytes, results in highly abnormal vascular patterning and instability. PMID: 22279205
Highly angiogenic and poorly invasive glioblastomas expressed low levels of beta8 integrin, whereas highly invasive glioblastomas with limited neovascularization expressed high levels of beta8 integrin. PMID: 21859829
Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. PMID: 21878622
miR-93 promotes the growth of, and angiogenesis in astrocytomas, by suppressing, at least in part, integrin-beta8 expression. PMID: 20956944
Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway PMID: 20519498

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Integrin beta chain family

Tissue Specificity

Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

Database Links

HGNC: 6163

OMIM: 604160

KEGG: hsa:3696

STRING: 9606.ENSP00000222573

UniGene: Hs.592171

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Code	CSB-EL011892HU
Size	96T,5×96T,10×96T
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Trial Size	24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Human Integrin beta-8(ITGB8) ELISA kit

Product Details

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Target Background