HMO1 Antibody

1. Persistent induction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO1 mRNA, but only in the presence of Tor1p. This down-regulation is accompanied by eviction of Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p. PMID: 28701348
2. HMO1 appears to have evolved a unique linker histone-like function involving the ability to stabilize both conventional nucleosome arrays as well as DNA regions characterized by low nucleosome density or the presence of noncanonical nucleosomes. PMID: 27903656
3. studied the genome-wide binding patterns of Nhp6, Hmo1 and the SWI/SNF complex, finding that most of gene promoters presenting high occupancy of this complex also display high enrichment of these HMG proteins. PMID: 28089519
4. Hmo1p functions to control DNA end resection, thereby preventing error-prone A-EJ repair and directing repairs towards classical NHEJ. The very low efficiency of DSB repair in kuDeltahmo1Delta cells further suggests that excessive DNA resection is inhibitory for A-EJ. PMID: 28336179
5. Both HMG boxes in Hmo1 are essential for DNA binding PMID: 25410521
6. Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence. PMID: 25979266
7. Hmo1's C-terminal tail, implicated in chromatin bending, facilitates the formation of catenations/hemicatenations and mediates the roles of Hmo1 in DNA damage tolerance pathway choice and sister chromatid junction formation. PMID: 24473148
8. Aurhors propose that Hmo1 has acquired species-specific functions and shares with UBF1 and Schizosaccharomyces pombe-Hmo1 an ancestral function to stimulate rDNA transcription. PMID: 24021628
9. The HMO1 promoter is regulated by TOR signaling through an HMO1- and Fhl1-dependent mechanism. PMID: 21924331
10. Hmo1 plays a novel role in transcription by forming the 5'-boundary (instead of -1 nucleosome on many other promoters) for the pre-initiation complex assembly zone on a subset of ribosomal protein genes promoters. PMID: 21288884
11. the combined activity of the Hmo 1 and the Ixr1 proteins provides efficient correction of both repair and replication errors. PMID: 20734765
12. The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending PMID: 20402481
13. HMO1 contains two functional DNA binding domains PMID: 15507436
14. Taken together, our data suggest that interactions between box A and the C-terminal tail induce a conformation that is required for DNA bending. PMID: 16533046
15. Hmo1 has a role in coordinating the transcription of rRNA and RP genes. PMID: 16612005
16. Data show that Hmo1 is directly involved in coordinating rDNA transcription by Pol I and ribosomal protein gene expression by Pol II under the control of the TOR pathway. PMID: 17875934
17. HMO1 may participate in start site selection of a subset of class II genes presumably via its interaction with TFIID. PMID: 18187511
18. Data demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1. PMID: 18451108
19. Data indicate that Top2 is dispensable for transcription and that Hmo1 and Top2 bind in the proximity of genes transcribed in S phase suppressing chromosome fragility at the mitosis-G1 transition. PMID: 19737516

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KEGG: sce:YDR174W

STRING: 4932.YDR174W