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| Code | CSB-E09299h |
| See More Details |  |
| Product Type | ELISA Kit |
| Size | 96T,5×96T,10×96T |
| Uniprot No. | O00253 |
| Lead Time | 3-5 working days |
| Abbreviation | AGRP |
| Protein Biological Process 1 | Cardiovascular |
| Target Name | agouti related protein homolog (mouse) |
| Alias | AGRT, ART, ASIP2, MGC118963, agouti related protein |
| Species | Homo sapiens (Human) |
| Sample Types | serum, plasma, cell culture supernates, urine |
| Detection Range | 31.25 pg/mL-2000 pg/mL |
| Sensitivity | 0.002 pg/mL |
| Assay Time | 1-5h |
| Sample Volume | 50-100ul |
| Detection Wavelength | 450 nm |
| Research Area | Cardiovascular |
| Protocol |
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
|
| Assay Principle | quantitative |
| Measurement | Sandwich |
| Target Details | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. |
| HGNC | 330 |
| RGD | 2068 |
| MGI | 892013 |
| Precision | Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess. |
| Linearity | To assess the linearity of the assay, samples were spiked with high concentrations of human AGRP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. |
| Typical Data | These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. |
| Involvement in disease | Obesity (OBESITY) |
| Subcellular Location | Secreted, Golgi apparatus lumen |
| Tissue Specificity | Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| Database Links |
HGNC: 330 OMIM: 601665 KEGG: hsa:181 STRING: 9606.ENSP00000290953 UniGene: Hs.104633 |
| Pathway | Adipocytokine signaling pathway |
AGRP Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA05699A0Rb | AGRP Antibody | Human | ELISA, IHC |
| CSB-PA05699B0Rb | AGRP Antibody, HRP conjugated | Human | ELISA |
| CSB-PA05699C0Rb | AGRP Antibody, FITC conjugated | Human | ELISA |
| CSB-PA05699D0Rb | AGRP Antibody, Biotin conjugated | Human | ELISA |
AGRP Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA999934 | AGRP Antibody | Human | ELISA,IHC |
| CSB-PA996514 | AGRP Antibody | Human | ELISA,IHC |
AGRP Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP001462HU CSB-BP001462HU CSB-MP001462HU |
Recombinant Human Agouti-related protein(AGRP) | Yeast Baculovirus Mammalian cell |
| CSB-EP001462HU | Recombinant Human Agouti-related protein(AGRP) | E.coli |
| CSB-RP056944h | Recombinant Human Agouti-related protein(AGRP),partial | E.coli |
Mouse Arachidonic Acid(AA) ELISA Kit
Detect Range: 15.625 ng/mL-1000 ng/mL
Sensitivity: 13.797 ng/mL
Mouse Agouti-related protein(AGRP) ELISA kit
Detect Range: 15.6 pg/mL-1000 pg/mL
Sensitivity: 3.9 pg/mL
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