Human Neuronal pentraxin-2(NPTX2) ELISA kit

1. Neuronal pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. This research may advance the current understanding of Alzheimer's disease etiopathogenesis, while expanding early diagnostic techniques through the use of novel pro-inflammatory biomarkers, such as NPTX2. PMID: 27444967
2. NPTX2 in human cerebrospinal fluid is reduced in subjects with Alzheimer's disease and shows robust correlations with cognitive performance and hippocampal volume. PMID: 28440221
3. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis. PMID: 27083956
4. we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. PMID: 26294210
5. NPTX2 is overexpressed specifically in ccRCC primary tumors. PMID: 24962026
6. NPTX2 repressed NF-kappaB activity by inhibiting AKT through a p53-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB-activated high-risk glioblastomas. PMID: 24078801
7. Promoter methylation of NPTX2 is associated with glioblastoma. PMID: 23624749
8. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas PMID: 23360791
9. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired. PMID: 23889936
10. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines. PMID: 22806544
11. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248. PMID: 22460132
12. Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2+), and lipid stress. PMID: 21812817
13. Data indicate that the aberrantly methylated NPTX2 gene may help to distinguish between chronic pancreatitis and pancreatic cancer with conventional diagnostic tools and could become a valuable diagnostic marker. PMID: 21778928
14. NPTX2, as a tumor-suppressor, plays an anti-tumor effect on pancreatic cancer and its low expression, due to promoter hypermethylation, may play a role in the tumorigenesis of pancreatic cancer. PMID: 21161403
15. study tested for the association of four SNPs of NPTX2 & haplotypes consisting of the SNPs with autism, between autistic patients & controls in a Japanese population; no significant difference was observed in allele, genotype or haplotype frequencies PMID: 17408830
16. pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases PMID: 17895837
17. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. PMID: 17987278
18. Homoplasmic cybrids harboring the 8993T-->G NARP mutation were also protected from death (75% vs 15% survival at 72 hours) by the supplemented medium and their ATP content was similar to controls PMID: 19667215

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HGNC: 7953

OMIM: 600750

KEGG: hsa:4885

STRING: 9606.ENSP00000265634

UniGene: Hs.3281