Human Squamous Cell Carcinoma Antigen 2,SCCAg 2 ELISA Kit

Code CSB-E04776h
Size 96T,5×96T,10×96T
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now
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Product Details

Target Name
serpin peptidase inhibitor, clade B (ovalbumin), member 4
Alternative Names
Leupin ELISA Kit; Peptidase inhibitor 11 ELISA Kit; PI 11 ELISA Kit; PI-11 ELISA Kit; PI11 ELISA Kit; Protease inhibitor (leucine serpin) ELISA Kit; SCCA 2 ELISA Kit; SCCA-2 ELISA Kit; SCCA1 ELISA Kit; SCCA2 ELISA Kit; SCCA2/SCCA1 fusion protein ELISA Kit; Serine (or cysteine) proteinase inhibitor; clade B (ovalbumin); member 4 ELISA Kit; Serpin B4 ELISA Kit; Serpin peptidase inhibitor; clade B (ovalbumin); member 4 ELISA Kit; SERPINB 4 ELISA Kit; SERPINB4 ELISA Kit; SPB4_HUMAN ELISA Kit; Squamous cell carcinoma antigen 1 ELISA Kit; Squamous cell carcinoma antigen 2 ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma
Detection Range
0.312 ng/ml-20 ng/ml
0.078 ng/ml
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Cell Biology
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

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Target Background

(From Uniprot)
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Gene References into Functions
  1. The combination of SCCA-IgM with common clinical data shows promising diagnostic performance for the detection of Non-alcoholic steato-hepatitis in hepatitis C virus patients PMID: 29712495
  2. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to respiratory syncytial virus PMID: 29122495
  3. Serum SCCA2 levels reflected disease severity and clinical type of atopic dermatitis. Serum SCCA2 may thus be a relevant biomarker for atopic dermatitis. PMID: 28734739
  4. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors. PMID: 26993499
  5. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC-I and CD1d expression. Intriguingly, expression of SERPINB9, SERPINB1, and SERPINB4 is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors PMID: 26963506
  6. It is a promising serological marker for hepatocellular carcinoma. PMID: 24635038
  7. our findings established that SCCA1 contributes to tumorigenesis by promoting EMT and a UPR-dependent induction of NF-kappaB and IL6 autocrine signaling that promotes a protumorigenic inflammation. PMID: 25213322
  8. demonstrate the generation of Pso p27 from SCCA1 with extracts from psoriatic scale and even more remarkably, the generation of Pso p27 from SCCA1 in the presence of mast cell associated chymase PMID: 24560885
  9. The results show that SCCA1 has diverse effects on many of the cellular events that characterize asthma and its role extends beyond protease inhibition. PMID: 23199842
  10. The serum level of SCCA is effective for detecting inverted papilloma (IP), including recurrent IP. In contrast, the SCCA2/SCCA1 ratio is useful for detecting squamous cell carcinoma among other sinonasal diseases. PMID: 23168150
  11. High serum SCCA1 levels are associated with lymph node metastasis, advanced tumor stage and tumor recurrence in oral cavity squamous cell carcinoma. PMID: 22576068
  12. both HPV status and the SCCA2/SCCA1 mRNA ratio are independently associated with prognosis in HNSCC PMID: 22937809
  13. Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis. PMID: 22406480
  14. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
  15. Data suggest that SCCA1 inhibits cell death induced by lysosomal injury while, on the other hand, it sensitizes cells to ER stress by activating caspase-8 independently of the death receptor apoptotic pathway. PMID: 21576355
  16. Elevated serum SCCA1 is associated with squamous cell carcinoma in cervical cancer. PMID: 21338226
  17. Transgenic mice expressing human SCCA1 showed higher liver regenerative potential compared to wild-type mice, supporting the dual role of this serpin as an anti-apoptotic and pro-proliferative stimulus for liver cells in vivo. PMID: 19956912
  18. expression in various normal tissue types and in tumor cell lines, increase in expression induced by TNF-alpha, and role in protecting tumor cells against TNF-alpha induced apoptsis PMID: 12437110
  19. SCCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans. PMID: 12702576
  20. SCCA2 acts as a cross-class serpin targeting an extrinsic cysteine proteinase from mites and may have a protective role against biological reactions caused by mites PMID: 14630915
  21. SCCA variants are overexpressed in hepatocellular carcinoma independently of tumour etiology PMID: 14970861
  22. SCCAs can alter invasive phenotype of cervical squamous cell carcinoma cells, probably by stimulating proMMP-9 production, and intact conformational structure of SCCAs is required for its stimulatory activity on proMMP-9 production PMID: 16211231
  23. Up-regulation of squamous cell carcinoma antigen-1 (SCCA1) suppresses c-Jun NH2-terminal kinase-1 (JNK1) and thus blocks UV-induced keratinocyte apoptosis. PMID: 16549498
  24. These results, in transgenic mice, suggest that SCAA1 might serve as an hepatitis B virus receptor or co-receptor and play an important role in mediating HBV entry into hepatocytes. PMID: 16820864
  25. SCCA2 regulates cell migration and invasion via E-cadherin expression, suggesting that SCCA2 may be involved in cancer behavior such as invasion or metastasis. PMID: 17016656
  26. SCCA2 may be involved in cancer behavior such as metastasis, and as such can be a useful marker in predicting lymph node metastasis. PMID: 18097581
  27. fatty acid-binding protein-5, squamous cell carcinoma antigens 2, alpha-enolase, annexin II, apolipoprotein A-I and albumin were detected at a high level in Atopic dermatitis skin lesions, but scarcely in the normal controls PMID: 19339807

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Subcellular Location
Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
Protein Families
Serpin family, Ov-serpin subfamily
Tissue Specificity
Squamous cells.
Database Links

HGNC: 10570

OMIM: 600518

KEGG: hsa:6318

STRING: 9606.ENSP00000343445

UniGene: Hs.123035

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