Human high sensitivity C-Reactive Protein,hs-CRP ELISA Kit

Instructions
Code CSB-E08617h
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name high sensitivity C-Reactive Protein,hs-CRP
Alternative Names Pentraxin 1, short ELISA Kit; C reactive protein ELISA Kit; C reactive protein pentraxin related ELISA Kit; C-reactive protein(1-205) ELISA Kit; CRP ELISA Kit; CRP_HUMAN ELISA Kit; MGC88244 ELISA Kit; Pentraxin 1 ELISA Kit; PTX 1 ELISA Kit; PTX1 ELISA Kit
Abbreviation hs-CRP
Uniprot No. P02741
Species Homo sapiens (Human)
Sample Types serum, plasma, cell culture supernates, tissue homogenates
Detection Range 0.625 ng/mL-40 ng/mL
Sensitivity 0.156 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Others
Assay Principle quantitative
Measurement Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%      
Three samples of known concentration were tested twenty times on one plate to assess.  
Inter-assay Precision (Precision between assays): CV%<10%      
Three samples of known concentration were tested in twenty assays to assess.    
             
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of human CRP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
  Sample Serum(n=4)  
1:200 Average % 95  
Range % 91-99  
1:400 Average % 104  
Range % 100-108  
1:800 Average % 93  
Range % 89-97  
1:1600 Average % 99  
Range % 93-104  
Recovery
The recovery of human CRP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample Type Average % Recovery Range  
Serum (n=5) 92 87-96  
EDTA plasma (n=4) 99 95-104  
             
             
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ng/ml OD1 OD2 Average Corrected  
40 2.859 2.876 2.868 2.760  
20 2.261 2.234 2.248 2.140  
10 1.436 1.412 1.424 1.316  
5 0.744 0.723 0.734 0.626  
2.5 0.408 0.422 0.415 0.307  
1.25 0.251 0.237 0.244 0.136  
0.625 0.167 0.158 0.163 0.055  
0 0.106 0.110 0.108    
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Citations

Target Data

Function Displays several functions associated with host defense
Gene References into Functions
  1. gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production. PMID: 29644527
  2. Combinative index (arterial lactate, NT-proBNP and CRP) could serve as a valuable predictor for the 28-day mortality rate in patients with sepsis. PMID: 30158031
  3. CRP rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing Systemic Lupus erythematosus PMID: 29556849
  4. The study showed that higher CRP and lower T3 levels were associated with stroke severity on admission. Functional outcome is likely secondary to stroke severity but functional outcome at discharge was associated with higher CRP levels. PMID: 30056003
  5. These findings reveal that the CRP- and PTX3-binding characteristics of FHL-1 differ from those of FH, likely underpinning independent immune regulatory functions in the context of the human retina. PMID: 29374201
  6. Short-term changes in daily movement behaviour can affect salivary CRP, a marker of systemic inflammation. PMID: 29499122
  7. M1 macrophages were characterized by elevated CRP mRNA expression (by 67%), CRP protein levels (by 108%), and upregulation of NFkappaB activation PMID: 29687414
  8. Levels of CRP and PCT in CSF did not present greater accuracy in differentiating bacterial from viral meningitis compared to serum levels. PMID: 30143494
  9. elevated serum C-reactive protein (CRP) is a well-known proxy for infections/immune abnormalities. Our results show elevated C-reactive protein levels to be associated with an increase in risk for schizophrenia. PMID: 29306175
  10. High CRP expression is associated with Nonalcoholic fatty liver disease. PMID: 29402657
  11. High C-reactive protein expression is associated with impaired glucose tolerance. PMID: 29078256
  12. Findings indicate that childhood infections do not have an independent, lasting effect on circulating inflammatory marker levels subsequently in childhood; however, elevated inflammatory markers may be harmful for intellectual development/function. PMID: 29198208
  13. maternal serum level has predictive value for chorioamnionitis PMID: 29430983
  14. serum level elevated in preterm labor leading to preterm birth PMID: 29426269
  15. Among healthy women attempting pregnancy after one or two pregnancy losses, elevated C-reactive protein is associated with reduced fecundability. PMID: 29317123
  16. Suggest a close association between CRP and metabolic syndrome, while the association between the dietary inflammatory index and MetS was limited. PMID: 29954070
  17. pre-procedural serum CRP could be a valuable predictor of global cardiovascular risk. PMID: 28128312
  18. Data suggest that serum CRP levels show positive association with ChildTurcottePugh scores in subjects with liver cirrhosis; GSH levels show negative association with ChildTurcottePugh scores; thus, CRP and GSH appear to exert synergistic effects in association with severity of liver cirrhosis. This cross-sectional study was conducted in Taiwan. (GSH = glutathione) PMID: 29861471
  19. Study shows for the first time that CRP activates signaling of integrin alpha2 via binding to integrin alpha2 and Fcgamma receptor I in breast cells and MDA-MB-231 triple-negative human breast cancer cells. PMID: 28846105
  20. This meta-analysis suggests that C-reactive protein/albumin ratio (CAR)may be a potential prognostic marker in solid cancers PMID: 28128229
  21. The results of the study suggest that the levels of C-reactive protein and tumor necrosis factor-alpha are important diagnostic markers of inflammation in patients with chronic pancreatitis and type 2 diabetes mellitus. PMID: 30280549
  22. Elevated serum C-reactive protein could be a bacterial infection predictor in decompensated cirrhosis. PMID: 29384797
  23. The results showed that the MI-based bio-sensing system had high selectivity and sensitivity for detection of Cardiac biomarkers . Compared with the control region, ultrasensitive detections of CRP and Mb were accomplished with the detection limits of 1.0 pg/mL and 0.1 pg/mL, respectively. PMID: 29857573
  24. Data suggest that C-reactive protein (CRP) may play an important role in the development of tongue squamous cell carcinoma (TSCC). PMID: 29385406
  25. For WBC, N (%), and ESR, both groups showed similar patterns of temporal values 14 days after surgery regardless of preoperative CRP level. Our findings could be used as guidelines for patient discharge and during the follow-up period after surgery. PMID: 29854731
  26. The neutrophil/lymphocyte ratio is a better addition to C-reactive protein than CD64 index as a marker for infection in COPD. PMID: 28185443
  27. This retrospective cohort study aimed to identify the early postoperative kinetics of C-reactive protein (CRP) and procalcitonin (PCT) in children undergoing tetralogy of Fallot (ToF) correction. PMID: 29111402
  28. After beta-blocker treatment, hs-CRP levels are associated with functional capacity in heart failure patients. PMID: 29396658
  29. Hypertensive patients with coronary tortuosity have a higher serum hs-CRP level concentration and have a higher incidence of lacunar infarction than hypertensive patients without coronary tortuosity. PMID: 29436255
  30. High CRP expression is associated with non-small cell lung cancer. PMID: 29549910
  31. T allele of rs1205 in CRP gene was protective against Takayasu arteritis in our patients. CC genotype was associated with involvement of coronary artery and ascending aorta. A trend toward a blunted CRP response seen in patients. PMID: 29024426
  32. Serum C-reactive protein (and COMP) levels were both associated with the incidence of knee osteoarthritis. PMID: 29351749
  33. coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors PMID: 29325799
  34. Data suggest that C-reactive-protein (CRP) concentration is weakly associated with global DNA methylation level, and this association was more clearly in individuals with the minor allele of the 5,10-methylenetetrahydrofolate reductase (MTHFR)missense SNP rs1801133. PMID: 29439678
  35. A longitudinal association between adolescent CRP levels and adult schizophrenia diagnosis indicates a potentially important role of inflammation in the pathogenesis of the illness PMID: 27622678
  36. rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities PMID: 29379005
  37. CRP levels predict the development of anastomotic leak and postoperative mortality after colorectal cancer surgery. PMID: 28132052
  38. Uremia patients receiving maintenance hemodialysis with hospitalacquired infection had increased serum inflammatory factors and high throughput hemodialysis significantly decreased CRP, IL2 and TNFalpha levels in the serum, suggesting that high throughput hemodialysis may be beneficial for the prevention of the infections in uremia patients. PMID: 29257244
  39. High CRP expression is associated with cardiovascular disease. PMID: 28724840
  40. The results of this meta-analysis suggest that increased CRP expression indicates a poorer prognosis in patients with bone neoplasms. PMID: 29668751
  41. C-reactive protein (CRP) recognized 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (POPG) in the supported 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) monolayers without calcium at pH 7.4 and 5.5. PMID: 29172154
  42. Used Ultra Performance Liquid Chromatography-Ultra Definition Mass Spectrometry-based proteomics to compare serum samples from 19 colorectal cancer (CRC) patients. The samples were first analyzed after dividing them into two categories based on CRP, CRP <30 and CRP >30, and the same samples were analyzed again after being divided into the categories short and long 5-year survival. PMID: 29630649
  43. CRP bound to surface CD32 (also known as FcgammaRII) on myeloma cells, which activated a pathway mediated by the kinase p38 MAPK and the transcription factor Twist that enhanced the cells' secretion of osteolytic cytokines. PMID: 29233917
  44. high-sensitivity C-reactive protein could have a role in recurrent stroke and vascular events in patients treated with statins PMID: 28302952
  45. Procalcitonin and CRP serum levels are associated with the appearance of intra-abdominal infection after colorectal cancer surgery. PMID: 28918433
  46. C-reactive protein polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, posttraumatic stress disorder, and C-reactive protein. PMID: 28867284
  47. Elevated CRP level is correlated with poor prognosis in patients with metastatic renal cell carcinoma receiving tyrosine kinase inhibitors treatment. (Meta-analysis) PMID: 29080691
  48. The study reveals that CRP might be a clear cell renal cell carcinoma development promoter. PMID: 28923830
  49. CRP distinguished sepsis and non-septic ICU patients. PMID: 28898742
  50. Suggest that hs-CRP may be a marker of comorbidities associated with worse health status in myocardial infarction. PMID: 28946036
  51. CRP, an upstream inflammatory marker, was independently associated with the risk of major adverse cardiovascular events, cardiovascular and all-cause mortality, myocardial infarction, heart failure, and cancer mortality in patients with stable coronary heart diseas PMID: 29066452
  52. Cumulative exposure to hs-CRP was dose dependently associated with a subsequent increased risk of cardiovascular disease and myocardial infarction. PMID: 29066453
  53. Preoperative CRP level is an independent predicting factor of over survival and cancer-specific survival in patients with metastatic renal cell carcinoma who receive cytoreductive nephrectomy. PMID: 28624829
  54. Interval change in CRP is a comparable measure to absolute CRP in the prognostication of acute pancreatitis severity. PMID: 28693979
  55. Serum CRP levels were correlated with abdominal aorta diameter and rs1205 was related to serum CRP concentrations in a Chinese population. PMID: 28549956
  56. Higher serum CRP levels were associated with higher baseline disability, suggesting systemic inflammation may contribute to disability independently of clinical vascular events. PMID: 28181636
  57. A decrease in C-reactive protein (CRP) as well as pretreatment CRP can be a predictive factor for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) treated with a tyrosine kinase inhibitor. PMID: 28778585
  58. Baseline C-reactive protein levels are significantly associated with the prevalence of atrial fibrillation and the risk of AF in Korean populations. PMID: 27915263
  59. Desloratadine exerted anti-inflammatory and antioxidant effects on chronic spontaneous urticaria (CSU) patients revealed by CRP. Patients' remission was synergistic to CRP attenuation emphasizing CRP relevance for CSU clinical assessment. PMID: 28351163
  60. this meta-analysis indicates that C-reactive protein CRP gene rs1205 polymorphism was not associated with the risk of colorectal cancer. PMID: 28706007
  61. Low ADIP [adiponectin] and high CRP [C-reactive protein] are associated with excessive %BF [body fat percent] and FG[fasting glucose] in AA [African Americans] women. ADIP/CRP, may be useful for detecting metabolic dysregulation. PMID: 29026382
  62. A biomarker of cardiac fibrosis, sDT2, and a biomarker of inflammation, hs-c-reactive protein, predict the risk of occurrence of atrial fibrillation in coronary artery disease patients. PMID: 28942872
  63. CRP showed statistically significant differences between the groups of septic and non-septic burn patients. PMID: 28454850
  64. Increased high-sensitivity C-reactive protein levels are associated with impaired microvascular reperfusion after percutaneous intervention in ST-elevation myocardial infarction patients. PMID: 28826799
  65. A high white blood cell count and CRP level on postoperative day 7 may be used to predict or detect surgical site infection. PMID: 28937461
  66. Elevated CRP serum levels were associated with increased risk of developing type 2 diabetes mellitus. PMID: 28716139
  67. Ninety-four DRESS cases were studied. All cases showed a CRP value >10 mg/L (the upper limit of normal). The mean CRP value was 109.2 +/- 79.4 mg/L. CRP values were significantly higher in 22 cases where a cause of inflammation besides DRESS could not be excluded (mean 162.1 vs. 92.9 mg/L; p = 0.003). PMID: 29656292
  68. CRP serum level is predictive of survival for patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors. PMID: 28733795
  69. Systemic inflammation, as indicated by C-reactive protein, independently predicts risk for hospitalizations in chronic kidney disease. PMID: 27312245
  70. High CRP level is associated with Type-2 diabetes and diabetic vascular disease. PMID: 28119309
  71. High C-reactive protein may be a favorable prognostic predictor in patients with non-small cell lung cancer following lobectomy PMID: 29715162
  72. CRP/albumin ratio is a novel but promising, easy-to-measure, repeatable, non-invasive inflammation-based prognostic score in acute pancreatitis. PMID: 28823374
  73. CRP was associated with carotid plaque presence and total plaque are in cross-sectional analyses, but was not an independent predictor of novel plaque formation or plaque progression. PMID: 28728065
  74. Serum SCC-Ag, hs-CRP, and CA-125 were higher in recurrence cervical patients which could be potential biomarkers for predicting cervical cancer recurrence risk. PMID: 28901315
  75. Acute and chronic exposure to tobacco smoking is associated with inflammation, as quantified by both GlycA and high-sensitivity C-reactive protein. PMID: 28838917
  76. The presence of lysophosphatidylcholine, a component of apoptotic membranes, increased CRP binding to all types of membranes. PMID: 28225631
  77. The CRP triallelic polymorphism and the CRP level are associated with the risk of incident thromboembolic stroke in patients with atrial fibrillatioN. PMID: 28498565
  78. rs3093059 and rs3091244 were significantly associated with the decreased risk of hemorrhagic stroke in men. In HS patients, rs3091244 was positively associated with the hsCRP elevation and rs2794521 was negatively associated with hsCRP elevation. PMID: 28721654
  79. The rs1130864 CRP polymorphism was associated with systemic lupus erythematosus (SLE) susceptibility and CRP levels, but not with disease activity, suggesting that this polymorphism may play a role in the pathophysiology of SLE through increasing the CRP that, probably, plays an inflammatory role in SLE pathophysiology. PMID: 28567557
  80. Despite the positive correlation between the polymorphism and CRP levels, there was no significant difference in the occurrence of post-operative atrial fibrillation (AF) between the different genotypes. These results suggest that increased CRP plasma levels that are not associated with an inflammatory process are not sufficient to trigger AF after cardiac surgery. PMID: 28506639
  81. we found highest pretreatment CRP serum concentrations in patients with metastatic tumors and TCs. High pretreatment CRP was associated with significantly worse FFR and CRP serum concentrations increased significantly in case of tumor recurrence. PMID: 28514756
  82. A significant positive association of Fibromyalgia to serum C-reactive protein was linked in part to body mass index. PMID: 28687081
  83. Normal C-reactive protein (CRP) values were observed in up to 28% of children with Crohn disease and 42% of children with ulcerative colitis at diagnosis. Correlation of CRP with Crohn disease activity during follow-up depended on their value at diagnosis and mode of analysis. CRP was not useful in predicting ulcerative colitis disease activity. PMID: 27741061
  84. In patients with food protein-induced enterocolitis syndrome (FPIES) caused by cow's milk, serum CRP increased in 50% of subjects at onset. Age at tolerance acquisition was significantly positively correlated with serum CRP at onset. Serum CRP is a useful parameter of poor prognosis in FPIES. PMID: 28432705
  85. Higher longitudinal serum high-sensitivity C-reactive protein levels elevated over time, were predictive of worse prognosis among continuous ambulatory peritoneal dialysis patients. PMID: 28676043
  86. The association between CRP level, symptoms, and ADL observed in advanced cancer patients receiving palliative care indicates that CRP level might be a good biomarker. PMID: 28247593
  87. these results suggest that that CRP may be a potent inducer of the anti-inflammatory cytokine IL-10 PMID: 28619036
  88. C-reactive protein (CRP) and N/L ratio did not predict poor clinical outcome in STS patients receiving neoadjuvant radiotherapy (RT). PMID: 29491077
  89. serum levels elevated in non-obese adolescents and young adults with polycystic ovary syndrome PMID: 28535403
  90. The research showed that the enhancement degree on contrast-enhanced ultrasound was closely correlated to C-reactive protein levels, the neovessel density and the macrophage number. PMID: 28585145
  91. preoperative serum C-reactive protein level is an independent and significant indicator for elevated morbidity and mortality after pulmonary resection PMID: 28577953
  92. Multivariate analysis identified thrombocytosis and serum C-reactive protein (CRP) level as independent prognostic factors in pancreatic cancer. PMID: 27984485
  93. Among patient with generalized anxiety disorder, those with alexithymia had higher CRP compared to non-alexithymic patients. PMID: 25856390
  94. An elevated CRP/Alb ratio is associated with Inflammation in Pancreatic Cancer. PMID: 27650825
  95. Circulating pentraxin nCRP has little pro-angiogenic effect but when dissociated into mCRP on the surface of endothelial cells it is able to trigger potent proangiogenic effects by inducing F3-gene upregulation and TF signaling. PMID: 27808345
  96. High baseline serum consentrations of IL-6 or CRP were associated with impaired prognosis in mCRC. IL-6 and CRP give independent prognostic information in addition to RAS and BRAF mutation status. PMID: 27738330
  97. Up-regulation of IL-8 and its association with the marker of clinical and inflammatory activity, CRP, suggest a role of this cytokine in the pathogenesis of chronic spontaneous urticaria. PMID: 29254299
  98. The present findings suggest that high circulating CRP is predictive of major cardiovascular events in peripheral artery disease patients (Review and Meta-Analysis). PMID: 28666785
  99. High CRP expression is associated with hepatocellular carcinoma and liver cirrhosis. PMID: 28801369
  100. C-reactive protein/albumin ratio (CAR), an inflammation-based prognostic score, is a potential independent predictor for disease progression and death in patients with operable non-small cell lung cancer. PMID: 27823974

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Subcellular Location Secreted
Protein Families Pentraxin family
Tissue Specificity Found in plasma.
Database Links

HGNC: 2367

OMIM: 123260

KEGG: hsa:1401

STRING: 9606.ENSP00000255030

UniGene: Hs.709456

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