Mouse Interleukin-10 receptor subunit alpha(IL10RA) ELISA kit

Instructions
Code CSB-EL011581MO
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name interleukin 10 receptor, alpha
Alternative Names Il10ra ELISA Kit; Il10r ELISA Kit; Interleukin-10 receptor subunit alpha ELISA Kit; IL-10 receptor subunit alpha ELISA Kit; IL-10R subunit alpha ELISA Kit; IL-10RA ELISA Kit; CDw210a ELISA Kit; Interleukin-10 receptor subunit 1 ELISA Kit; IL-10R subunit 1 ELISA Kit; IL-10R1 ELISA Kit; CD antigen CD210 ELISA Kit
Abbreviation IL10RA
Uniprot No. Q61727
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates, cell lysates
Detection Range 0.312 ng/mL-20 ng/mL
Sensitivity 0.078 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Receptor for IL10; binds IL10 with a high affinity.
Gene References into Functions
  1. These results indicate that IL10R-mediated regulation of macrophage function during the early postnatal period is indispensable for preventing the development of murine colitis. PMID: 28678006
  2. cross-talk between type I IFN and IL-10R signaling pathways may represent a key host cellular mechanism to investigate further in order to unravel the balance between pathogenic inflammation and homeostasis of the colon. Taken together, our data clearly demonstrate that type I IFN signaling is pathogenic in S. typhimurium colitis PMID: 29190678
  3. this study shows that the upregulation of IL-10Ra by STAT3 contributed to the suppressive function of dendritic cellss following histone deacetylase inhibition PMID: 27866206
  4. TR1 cell regulatory activity is dependent on IL-10 receptor signaling. PMID: 28003377
  5. loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone-marrow-derived macrophages and their ability to secrete IL-10. PMID: 24792912
  6. loss of IL-10 receptor expression impaired the critical conditioning of monocyte-derived macrophages and resulted in spontaneous development of severe colitis. PMID: 24792913
  7. Recent findings review how IL10- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine intestine. PMID: 24507158
  8. Treatment of mice with rIFN-gamma was sufficient to drive expression of IL-10R1 in the colonic epithelium. Intestinal epithelial-specific IL-10R1-null mice were more susceptible to DSS colitis associated with increased intestinal permeability. PMID: 24367025
  9. Inhibition of IL-10R signaling during bacillus Calmette-Guerin (BCG) vaccination increases and balances IFN-gamma and IL-17A responses in favor of the host. PMID: 22972927
  10. IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo. PMID: 22753938
  11. IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PMID: 22291593
  12. showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor alpha (IL-10Ralpha) in vivo PMID: 21511184
  13. reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody PMID: 12186845
  14. Immunocytochemistry data shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 receptor 1. PMID: 16256304

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Type II cytokine receptor family
Database Links

KEGG: mmu:16154

STRING: 10090.ENSMUSP00000034594

UniGene: Mm.379327

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