Rat Proprotein convertase subtilisin/kexin type 9(PCSK9) ELISA kit

1. up-regulation of intestinal gene expression of LDL-R and PCSK9 following voluntary wheel running PMID: 29938676
2. This is the first report about the expression of PCSK9 in adult terminal differentiated ventricular cardiomyocytes PMID: 28913715
3. PCSK9 is regulated in vascular smooth muscle cells by TLR-4 - SAPK/JNK signaling, a pathway important in inflammation and metabolism. PMID: 28232185
4. Hnf1alpha gene expression is upregulated in the liver of rats with experimentally induced chronic renal failure, showing an association between circulating PCSK9 and TAGs PMID: 26978583
5. PCSK9 could serve as a novel molecular biomarker for the non-invasive prenatal screening of neural tube defects. PMID: 26691006
6. coordinated up-regulation of Pcsk9 and Srebf-2 genes expression suggests that SREBF-2 may play a key role in regulation of Pcsk9 gene expression, circulating PCSK9 level, and hypercholesterolemia in experimental CRF PMID: 26481479
7. LDLR deficiency, hypercholesterolemia and elevated plasma LDL in NS are associated with upregulation of PCSK9 and IDOL. PMID: 24166456
8. Gene expression of hepatic LDL-R, Lrp1, Pcsk9, SREBP-2 and HMGCoA-r were reduced (p<0.05) in ovariectomy compared to Sham rats. PMID: 24619822
9. data provided the first line of the evidence that BBR, similar to the Sim, could increase the expression of PCSK9 levels in HFD rats through SREBP-2 activation PMID: 24755036
10. Elevated serum PCSK9 concentration by ezetimibe, Xuezhikang and pitavastatin alone or in combination was found prior to the alterations of lipid profile in rats. PMID: 24533584
11. Phaleria macrocarpa fruit aqueous extract reduced body weight/improved blood lipid profile of hypercholesterolemic rats. The improvement is likely to be regulated by LDL receptor and PCSK9. PMID: 21763412
12. Our functional characterization of Narc 1 reinforces the inference drawn that this enzyme is most closely related to representatives of the proteinase K family, but it is also sufficiently different to warrant its classification in a separate sub-family. PMID: 14622975
13. Human, mouse, and rat PCSK9 promoters contain 2 typical conserved motifs for cholesterol regulation: a sterol regulatory element (SRE) and an Sp1 site. PMID: 15178557
14. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is processed in the Endoplasmic Reticulum, and the mature convertase is secreted in the plasma. PMID: 16462892
15. mechanism by which NARC 1 overexpression induces cell death in cerebellar granule neurons remains unclear; correlation seen between Narc 1 active site serine in transiently expressed protein and induction of BAF-sensitive component of cell death phenotype PMID: 17051583
16. explaining the lack of reduction in LDL receptor protein levels. These observations indicate that the rate of LDL receptor cycling (function) in diabetic rats is decreased resulting in higher serum LDL levels. PMID: 18054320
17. The hormonal and dietary regulation of hepatic LDLRs also involves posttranscriptional regulation by PCSK9. PMID: 19008317
18. NARC-1 is a proteinase K-like subtilase with a role in the differentiation of cortical neurons. PMID: 12552133

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KEGG: rno:298296

STRING: 10116.ENSRNOP00000008536

UniGene: Rn.19195