Recombinant Human Indian hedgehog protein(IHH) (Active)

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Code CSB-AP000421HU
Product Type Other
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Uniprot No. Q14623
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered 1 × PBS, pH 7.4,lyophilized
Alias IHH
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by C3H10T1/2(CCL-226) cells is 3.0-10 μg/ml.
Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence IIGPGRVVGS RRRPPRKLVP LAYKQFSPNV PEKTLGASGR YEGKIARSSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDRLNSLAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRNKYGLL ARLAVEAGFD WVYYESKAHV HCSVKSEHSA AAKTGG
Research Area Stem Cells?
Source E.coli
Gene Names IHH
Expression Region 29-202aa
Tag Info Tag-Free
Mol. Weight 19.8 kDa
Protein Description Partial
PubMed ID 15489334; 7590746; 7720571; 9593755; 16335952; 20519495; 21537345; 11455389; 12384778; 12632327
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Function Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification
Involvement in disease Brachydactyly A1 (BDA1); Acrocapitofemoral dysplasia (ACFD)
Subcellular Location Indian hedgehog protein N-product: Cell membrane, Lipid-anchor, Extracellular side, Note=The N-terminal peptide remains associated with the cell surface, SUBCELLULAR LOCATION: Indian hedgehog protein C-product: Secreted, extracellular space
Protein Families Hedgehog family
Tissue Specificity Expressed in embryonic lung, and in adult kidney and liver.
Database Links

HGNC: 5956

OMIM: 112500

KEGG: hsa:3549

STRING: 9606.ENSP00000295731

UniGene: Hs.654504

Pathway Hedgehog signaling pathway

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