ALOXE3 Antibody

Code CSB-PA863156ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA863156ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA863156ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ALOXE3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
ALOXE3 antibody; Arachidonate lipoxygenase 3 antibody; e LOX 3 antibody; E LOX antibody; e-LOX-3 antibody; eLOX3 antibody; Epidermal lipoxygenase antibody; Epidermis-type lipoxygenase 3 antibody; Lipoxygenase 3 antibody; LOXE3_HUMAN antibody
Raised in
Species Reactivity
Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.
Gene References into Functions
  1. Case Report: ALOXE3 mutation causing congenital ichthyosis and recurrent eczema. PMID: 27868147
  2. In summary, we have identified three novel sequence variants, one in TGM1 and two in ALOXE3, in three consanguineous families segregating lamellar ichthyosis and congenital ichthyosiform erythroderma types of autosomal recessive congenital ichthyosis. PMID: 26578203
  3. Case Report: homozygous ALOXE3 mutation causing autosomal recessive congenital ichthyosis. PMID: 25423909
  4. Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review] PMID: 23954555
  5. This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3. [review] PMID: 24021977
  6. Autosomal recessive congenital ichthyosis patients with NIPAL4 mutations and abnormal ichthyin expression showed increased 12R-LOX and eLOX-3 staining and a colocalization signal of these LOXs that was three times the normal intensity. PMID: 22622417
  7. On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1. PMID: 20923767
  8. Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. PMID: 20921226
  9. ALOX12B mutations are the leading cause of self-improving collodion ichthyosis in Scandinavia, followed by ALOXE3 mutations, and TGM1 mutations PMID: 19890349
  10. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. PMID: 11773004
  11. eLOX-3 hydrolase functions in the normal process of skin differentiation, and that the loss of function mutations are the basis of the LOX-dependent form of Non-bullous congenital ichthyosiform erythroderma. PMID: 15629692
  12. The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX enzyme in mouse skin point to a potential LOX pathway for the production of epoxyalcohol in murine epidermal differentiation. PMID: 17045234
  13. Formation of a ligand for the nuclear receptor PPARalpha may be one possibility by which 12R-LOX and eLOX3 contribute to epidermal differentiation. PMID: 17436029
  14. mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B may have roles in autosomal recessive congenital ichthyosis PMID: 19131948

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Involvement in disease
Ichthyosis, congenital, autosomal recessive 3 (ARCI3)
Subcellular Location
Protein Families
Lipoxygenase family
Tissue Specificity
Predominantly expressed in skin.
Database Links

HGNC: 13743

OMIM: 606545

KEGG: hsa:59344

STRING: 9606.ENSP00000314879

UniGene: Hs.232770

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