Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA156794 |
| Size | US$299 |
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| Have Questions? | Leave a Message or Start an on-line Chat |
| Uniprot No. | Q8NET8 | ||||||
| Target Names | TRPV3 | ||||||
| Raised in | Rabbit | ||||||
| Species Reactivity | Human,Mouse | ||||||
| Immunogen | Synthetic peptide of Human TRPV3 | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated | ||||||
| Isotype | IgG | ||||||
| Purification Method | Antigen affinity purification | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | ||||||
| Form | Liquid | ||||||
| Tested Applications | ELISA,IHC | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
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| Involvement in disease | Olmsted syndrome (OLMS); Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2) |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Protein Families | Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV3 sub-subfamily |
| Tissue Specificity | Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). |
| Database Links |
HGNC: 18084 OMIM: 607066 KEGG: hsa:162514 STRING: 9606.ENSP00000461518 UniGene: Hs.446255 |
