Recombinant Human C2 calcium-dependent domain-containing protein 4B (C2CD4B)

Code CSB-YP008080HU
MSDS
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Source Yeast
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Code CSB-EP008080HU
MSDS
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Source E.coli
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Code CSB-EP008080HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008080HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP008080HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
C2CD4B
Uniprot No.
Alternative Names
C2CD4B; FAM148B; NLF2; C2 calcium-dependent domain-containing protein 4B; Nuclear-localized factor 2; Protein FAM148B
Species
Homo sapiens (Human)
Expression Region
1-364
Target Protein Sequence
MRLLEKLCSS AAGSSAPKPA FAKVLTPNRI PEFCIPPRLP APCTLESPIR AAAVPRRCAA ESDLWPRAAD EDAGRTDWDP RSQAALSLPH LPRVRTTYGF CALLESPHTR RKESLLLGGP PAPRPRAHSC GGGGGPDAPL GTLCGPRGPG PATPAAPGGP RLPQDALAAG PRRCRLLRVP DGLLSRALRA GRSRRLARVR SVSSGNEDEE RRAGSESPAR APSSSPLSSR APLPERLEAK GTVALGRAGD ALRLAAEYCP GTRRLRLRLL RAESLFGGAP GPRAVRCRLS LVLRPPGTAR WQCSAVVGRS RKASFDQDFC FDGLSEDEVR RLAVRVKARD EGRGRDRGRL LGQGELSLGA LLLL
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May be involved in inflammatory process. May regulate cell architecture and adhesion.
Gene References into Functions
  1. rs7163757 contributes to genetic risk of islet dysfunction and type 2 diabetes by increasing NFAT-mediated islet enhancer activity and modulating C2CD4B, and possibly C2CD4A, expression in (patho)physiologic states. PMID: 29625024
  2. The present data thus provide evidence for a limited role for changes in VPS13C expression in conferring altered type 2 diabetes risk at this locus, particularly in females, and suggest that C2CD4A, but not C2CD4B, may also be involved. PMID: 27329800
  3. Loss of NLF2 gene expression in the endometrium of patients with implantation failure after in vitro ertilization treatment. PMID: 22885067
  4. Single nucleotide polymorphism in C2CD4B is associated with type 2 diabetes. PMID: 20818381
  5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20571754
  6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20818381
  7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20419449
  8. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20081858
  9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20185807
  10. NLF2 may play a role in regulating genes which control cellular architecture. PMID: 15527968

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Subcellular Location
Nucleus.
Protein Families
C2CD4 family
Tissue Specificity
Specifically expressed in endothelial cells.
Database Links

HGNC: 33628

OMIM: 610344

KEGG: hsa:388125

STRING: 9606.ENSP00000369755

UniGene: Hs.144372

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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