Recombinant Human Disks large homolog 4(DLG4)

1. DNA methylation of DLG4 and of human hippocampus and prefrontal cortex in major depression is unchanged in comparison to healthy individuals. PMID: 28645745
2. results suggest that rare missense mutations in the candidate PSD genes may increase susceptibility to SZ and/or ASD. These findings may strengthen the theory that rare, non-synonymous variants confer substantial genetic risks for these disorders PMID: 27271353
3. in postsynaptic densities, PSD95 palmitoylation, conformation, and its interactions are dynamic when associated with AMPARs and more stable when associated with NMDARs PMID: 27956638
4. a dual role for PSD-95 in stabilizing synaptic NMDARs by binding directly to GluN2B but also by promoting synaptic exclusion and degradation of the negative regulator STEP61. PMID: 27457929
5. the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role. PMID: 28874660
6. Phosphorylation at Y397 induced a significant increase in affinity for stargazing. The strategy presented here to generate site-specifically phosphorylated PDZ domains provides a detailed understanding of the role of phosphorylation in the regulation of PSD95 interactions. PMID: 28692247
7. This study demonstrated that a significant decrease in the protein level of PSD-95 in major depression disorder. PMID: 27661418
8. These results indicate that PKC promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 and calcium/calmodulin-dependent kinase II and also by inducing expression of PSD-95 and synaptophysin. PMID: 27330081
9. The differences in cortical NMDAR expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine. PMID: 26013316
10. Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders. PMID: 27072977
11. Data demonstrate a role for SNAP-25 in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity. PMID: 25678324
12. Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ domains. PMID: 25658767
13. In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles PMID: 25849917
14. An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia. PMID: 25104558
15. Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease. PMID: 25410733
16. The postsynaptic membrane protein PSD95 was increased in schizophrenia in CA3 tissue, but not in CA1 tissue. PMID: 25585032
17. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. PMID: 24513855
18. PSD-95 mRNA G-rich region folds into alternate G quadruplex conformations that coexist in equilibrium and miR-125a forms a stable complex with PSD-95 mRNA. PMID: 25406362
19. Polymorphisms of DRD1, DLG4 and HOMER1 are associated with opiate abuse. PMID: 23044706
20. The PDZ1 domain of PSD-95 has a shallow binding pocket that accommodates a peptide ligand involving far fewer interactions and a micromolar affinity PMID: 23394112
21. No association was found between the seven single nucleotide polymorphisms in DLG4 and schizophrenia. PMID: 23921260
22. A putative role for DLG4 in schizophrenia pathogenesis, evidenced by haplotype association, has been described. PMID: 23936182
23. interactions of G protein-coupled receptors with postsynaptic density protein 95 PMID: 23691031
24. Fyn mediates postsynaptic density protein- 95Y523 phosphorylation, which may be responsible for the excitotoxic signal cascades and neuronal apoptosis in brain ischemia and amyloid-beta peptide neurotoxicity. PMID: 22709448
25. Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization PMID: 22843680
26. a role of PAR-1 in spine morphogenesis in hippocampal neurons through phosphorylating PSD-95. PMID: 22807451
27. study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization PMID: 22673509
28. Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic density-95 (PSD-95) protein, a membrane-associated guanylate kinase (MAGUK). PMID: 21965656
29. tetrad complex shows the close association of the Kir2.1 cytoplasmic domains and the influence of PSD-95 mediated self-assembly on the clustering of these channels PMID: 21756874
30. In developing visual cortex TrkB and protein kinase M zeta, two critical regulators of synaptic plasticity, facilitate PSD-95 targeting to synapses PMID: 21849550
31. Genetic and functional analysis of the DLG4 gene encoding the post-synaptic density protein 95 in schizophrenia PMID: 21151988
32. Our current findings, suggesting decreased levels of PSD95, NR2A, and LRP-1, with elevated levels of caspase-3 and Bcl2 proteins, may reflect or contribute to neuronal and synaptic loss in the amnestic mild cognitive impairment hippocampus PMID: 19774677
33. PSD-95 has a role in regulating the functional activity and intracellular trafficking of 5-HT2A receptors and possibly other GPCRs PMID: 12682061
34. A single nucleotide polymorphism was identified as not significantly associated with schizophrenia. PMID: 12950712
35. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current PMID: 15317815
36. ApoEr2 can form a multiprotein complex with NMDA receptor subunits and PSD95 PMID: 16332682
37. it is unlikely that the PSD-95 polymorphisms investigated play a substantial role in conferring susceptibility to schizophrenia in the Chinese population PMID: 17093888
38. GABARAP and DLG4 genes are involved in the etiology of nicotine dependence in European-American smokers. PMID: 17164261
39. thermodynamic parameters associated with the binding of several series of linear peptides to the third PDZ domain of PSD-9 have been measured using isothermal titration calorimetry PMID: 17474715
40. The results clearly indicate that D1R-modulated NR1a/NR2B receptor function depends on PSD-95 and is subjected to the regulation of PKA and PKC. PMID: 17506933
41. PSD-95, the Kv1.3 potassium channel, and insulin receptor serine kinase co-localize to regulate membrane excitability and synaptic transmission at critical locations in the olfactory bulb. PMID: 17854350
42. PSD-95 levels increased postnatally to reach a stable plateau by early childhood with a slight reduction in late adolescence and early adulthood PMID: 17916412
43. These results suggest that NR2A and NR2B may associate with PSD-95 but with different affinities. This may be important in the determination of the lateral mobility of NMDA receptor subtypes in post-synaptic membranes. PMID: 18308477
44. Increase in postsynaptic density protein PSD-95 expression positively correlates with beta amyloid and phosphorylated Tau proteins in Alzheimer's disease cases. PMID: 18424056
45. This study found that the PSD-95 protein level significationalty elevated in pateint with deression. PMID: 18570704
46. The DLG4 protein enhances the resensitization of the D1 DA receptor by accelerating D1 receptor recycling to the cell membrane. PMID: 19274064
47. These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia as PSD95, SynGAP and MUPP1 expression is altered. PMID: 19483657
48. An altered association between membrane-associated guanylate kinases (such as PSD-95) and NMDA receptors in mutant huntingtin-expressing cells contributes to increased susceptibility to excitotoxicity. PMID: 19726651
49. validated occurrence of an unusual TG 3' splice site in intron 5 PMID: 17672918

Show More

Hide All

HGNC: 2903

OMIM: 602887

KEGG: hsa:1742

STRING: 9606.ENSP00000293813

UniGene: Hs.463928