Recombinant Human E3 ubiquitin/ISG15 ligase TRIM25(TRIM25)

1. formation of unanchored K63-linked poly-ubiquitin chains is unchanged by NS1 binding, indicating that RING dimerisation of TRIM25 is not affected by NS1 PMID: 29739942
2. The RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain, which we postulate to be a novel RNA-binding domain. PMID: 29117863
3. TRIM25 inhibits hepatocellular carcinoma progression by targeting MTA1. PMID: 28861931
4. TRIM25 is a key determinant of breast cancer metastasis. PMID: 28813674
5. V interaction with TRIM25 and RIG-I prevents TRIM25-mediated ubiquitination of RIG-I and disrupts downstream RIG-I signaling to the mitochondrial antiviral signaling protein. PMID: 29321315
6. HPV E6 oncoprotein antagonizes the activation of the cytoplasmic innate immune sensor RIG-I by targeting its upstream regulatory enzymes TRIM25 and USP15. We further show that the RIG-I signaling cascade is important for an antiviral innate immune response to HPV16 infection PMID: 29263274
7. this study shows thatTRIM25 targets ERG for degradation in prostate cancer PMID: 27626314
8. TRIM25 actively participates in higher-order assembly of the RIG-I signalosome. PMID: 27425606
9. Our results indicate that TRIM25 is associated with cisplatin resistance and 14-3-3sigma-MDM2-p53 signaling pathway is involved in this process, suggesting targeting TRIM25 may be a potential strategy for the reversal of cisplatin resistance. PMID: 28867193
10. expression of TRIM25 might be critical for lung cancer cell migration, proliferation as well as doxorubicin resistance. PMID: 26113559
11. Disturbed p53-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 overexpression. PMID: 27903487
12. the data uncover TRIM25 as a bona fide zinc-finger antiviral protein cofactor that leads to increased zinc-finger antiviral protein modification enhancing its translational inhibition activity. PMID: 28060952
13. Studies showed that 70% of breast cancer patients were positive for Trim25 expression. PMID: 27528750
14. we provide a detailed characterization of the TRIM ligases TRIM25 and TRIM32 and show how their oligomeric state is linked to catalytic activity PMID: 27154206
15. The severe acute respiratory syndrome coronavirus N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase, thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I) and inhibiting TRIM25-mediated RIG-I ubiquitination and activation. PMID: 28148787
16. TRIM25 is required for Zinc finger antiviral protein optimal binding to target mRNA. PMID: 28202764
17. TRIM25 may exert its function through TGF-beta pathway. PMID: 26754079
18. TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-kappaB. PMID: 26299329
19. Data show that TRIM25 enhances p53 and Mdm2 abundance by preventing their proteasomal degradation. At the same time, TRIM25 inhibits p53's transcriptional activity and dampens the response to DNA damage. PMID: 25728675
20. The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (RIG-I)-induced type I interferon expression. PMID: 26138103
21. Trim25 binds to the conserved terminal loop (CTL) of pre-let-7 and activates TuT4, allowing for more efficient Lin28a-mediated uridylation. PMID: 25457611
22. Our data uncovers a previously unknown functional link between gp78 and TRIM25 and provides mechanistic insight into gp78-mediated protein ubiquitylation. PMID: 24810856
23. Data indicate ubiquitin-specific protease 15 (USP15) as a critical regulator of the tripartite motif protein 25 (TRIM25)- and RNA sensor retinoic acid-inducible gene-I (RIG-I)-mediated antiviral immune response PMID: 24399297
24. In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25. PMID: 24131985
25. Study reports that RLR activation triggers MAVS ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling. PMID: 22626058
26. EFP mediates estrogen-induced ATBF1 protein degradation in breast cancer cells. PMID: 22452784
27. Studies indicate that the splice variant of RIG-I encodes a protein that lacks the first CARD of RIG-I, and the variant RIG-I protein is not ubiquitinated by TRIM25. PMID: 21890623
28. RING-IBR-RING E3 ligase domains of HOIL-1L and HOIP bind and induce proteasomal degradation of TRIM25, whereas the NZF domain of HOIL-1L competes with TRIM25 for RIG-I binding PMID: 21292167
29. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains. PMID: 21266548
30. The regulation of Efp and bFGF expression during endometrial carcinogenesis suggests their potential utility as a prognostic biomarker. PMID: 20127022
31. Efp controls breast cancer growth through ubiquitin-dependent proteolysis of 14-3-3sigma. PMID: 12943693
32. Results indicate that estrogen-responsive finger protein is widely expressed and may play important roles in various human tissues, possibly through estrogen receptors. PMID: 15130519
33. Over expression of Estrogen-responsive finger protein is associated with tumor progression of breast carcinoma PMID: 16144914
34. 14-3-3 sigma expression inversely correlated with estrogen receptor alpha, progesterone receptor and estrogen-responsive finger protein, and positively correlated with myometrial invasion and lymph node metastasis in endometrial adenocarcinoma PMID: 16271083
35. Efp is an IFN-responsive gene that potentially mediates IFN actions, involved in ISGylation and ubiquitination of proteins including Efp itself. PMID: 17069755
36. Our results indicate that EFP functions as a cofactor for ERalpha-mediated transcription. PMID: 17418098
37. role of the intact tandem CARD for TRIM25-mediated RIG-I activation; TRIM25 binds the RIG-I first CARD and subsequently ubiquitinates its second CARD PMID: 18948594
38. estradiol and tamoxifen may regulate the growth of endometrial carcinoma cells by stimulating VEGF production through Efp. PMID: 19148513
39. Viral nonstructural protein 1 inhibits activation of RIG-I by binding to TRIM25. PMID: 19454344
40. NS1 inhibits TRIM25-mediated RIG-I ubiquitination, thereby suppressing RIG-I signal transduction. PMID: 19454348

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HGNC: 12932

OMIM: 600453

KEGG: hsa:7706

STRING: 9606.ENSP00000323889

UniGene: Hs.528952