Recombinant Human Low-density lipoprotein receptor-related protein 2(LRP2),partial

1. megalin is critical for mitochondrial biology; mitochondrial intracrine signaling is a continuum of the retrograde early endosome-to-Golgi-Rab32 pathway and defects in this pathway may underlie disease processes in many systems. PMID: 29916093
2. patients with OCRL-1 mutations or type 1 Dent disease showed abnormally low levels of urinary A-megalin PMID: 27766457
3. An Emerging Role for Megalin as a Regulator of Protein Leak in Acute Lung Injury. PMID: 29090957
4. Review of LRP2 function. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans. PMID: 26872844
5. A novel LRP2 missense variant rs17848169 (N2632D) was found to be associated with lower risk for T2D-ESRD in this population. PMID: 27197912
6. we discovered one novel locus (LRP2; most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)). PMID: 28739605
7. miR-148b directly down-regulates renal megalin expression. PMID: 28331063
8. Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules. PMID: 28289043
9. The studies suggest that impaired endocytosis of megalin/cubilin ligands, hemoglobin and albumin, rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients. PMID: 28356267
10. VDR and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function. PMID: 28446629
11. the main role for placental megalin is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin in the cytotrophoblasts. PMID: 27798286
12. specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2/Akt pathway PMID: 27241555
13. abundances of megalin and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries PMID: 27072056
14. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability PMID: 26529358
15. The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure. PMID: 25304941
16. we are the first to identify the association between LRP2 and gout in a Chinese population and to confirm this association in Asians. PMID: 26147675
17. Two novel LRP2 mutations, a homozygous nonsense mutation and a missense mutation in two unrealted families with Donnai-Barrow syndrome. PMID: 25682901
18. Loss of LRP2 is associated with buphthalmos PMID: 26439398
19. melanoma cell expression of LRP2/megalin significantly decreases melanoma cell proliferation and survival rates. PMID: 25585665
20. levels of urinary C-megalin are associated with histological abnormalities in adult IgAN patients PMID: 25502002
21. A new mutation in LRP2 causes a predominantly ocular phenotype suggestive of Stickler syndrome. PMID: 23992033
22. LRP2 sequencing reveals multiple rare variants associated with urinary trefoil factor-3 PMID: 24876117
23. Serum uric acid-related gene LRP2 is not involved in gout susceptibility. PMID: 24366390
24. Transgenic/knock-out megalin-deficient mice develop anxiety behavior and impaired learning, as described in Alzheimer's disease. PMID: 24254699
25. Association of the T-allele of a single nucleotide polymorphism in LRP2 with gout risk in the Maori and Pacific subjects was consistent with this allele increasing serum urate in Japanese individuals PMID: 24286387
26. LOS treatment decreased microalbuminuria induced by Cd apparently through a cubilin receptor-dependent mechanism but independent of megalin. PMID: 24093454
27. Data suggest that endodermal layer of yolk sac and syncytiotrophoblast/cytotrophoblast cells of placental villi express megalin mRNA/protein; expression of megalin protein (but not mRNA) is up-regulated as gestation/placentation progresses. PMID: 23978537
28. This review explores current evidence linking megalin expression and function to the development, diagnosis, and progression of acute kidney injury --{REVIEW} PMID: 24197071
29. Megalin and Dab2 were expressed in prostate and colon epithelial cells, which was markedly enhanced following treatment with retinoic acid PMID: 23909735
30. The hypothalamic clusterin-low-density lipoprotein receptor-related protein-2 axis is a novel anorexigenic signalling pathway. PMID: 23673647
31. results suggested that GSTT1 wild genotype and C-allele of megalin gene rs2228171 SNPs might be risk factors for cisplatin-induced ototoxicity PMID: 23274376
32. Using NMR titration data in HADDOCK, we have generated a three-dimensional model describing the complex between megalin and gentamicin. PMID: 23275343
33. Expression of megalin and cubilin is decreased during experimental endotoxemia, which may contribute to an increase in urine levels of albumin during acute renal failure. PMID: 22437417
34. analysis of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders PMID: 22578327
35. This study confirmed that LRP2 rs2544390 C/T at intron 1 was associated with serum uric acid levels among Japanese males with SLC22A12 258WW, SLC2A9 rs11722228C allele, ABCG2 126QQ and 141Q allele. PMID: 22565184
36. A total of 330 Chinese female-offspring nuclear families with 1088 individuals and 400 Chinese male-offspring nuclear families with 1215 individuals were genotyped at six tag single nucleotide polymorphisms of the LRP2 gene. PMID: 22174918
37. Sex-specific VDR and Megalin gene variations can modify age-related cognitive decline among US adults. PMID: 22170372
38. megalin and cubilin are involved in the metabolism of vitamin D by reabsorbing vitamin D binding protein; dysfunction of these receptors is likely to be associated with the development of vitamin D deficiency in patients with chronic kidney disease PMID: 21595846
39. allele (A) of the rs3755166 polymorphism within LRP2 gene may contribute to Alzheimer's disease risk in the Chinese Han Population PMID: 20971101
40. in anagen VI hair follicles megalin was found in all keratinocytes of the distal region PMID: 21104416
41. Data show that MT-I + II and megalin are significantly altered in CNS lymphoma relative to controls. PMID: 20038220
42. No defect in the trafficking or function of megalin upon OCRL1 knockdown. PMID: 19940034
43. Megalin and cubilin: multifunctional endocytic receptors. A review. PMID: 11994745
44. This study reveals that LRP2 is a major autoantigen in rheumatoid arthritis and probably drives the production of anti-LRP2 autoantibodies, which may play pathological roles by inhibiting the reabsorbing function of LRP2. PMID: 12723989
45. megalin has a role in thyroid homeostasis with possible implications in thyroid diseases PMID: 14657389
46. a binding affinity of disabled homolog 2 mitogen-responsive phosphoprotein interaction domain for megalin CT of K(D) = 2.6 x 10(-7) +/- 5.3 x 10(-8) PMID: 15134832
47. megalin endocytosed NGAL by a mechanism completely blocked by an antibody against megalin PMID: 15670845
48. Further studies on the intracellular molecular signalling associated with megalin-mediated metabolic pathways may lead to the development of novel strategies for the treatment of nephropathies related to diabetes and metabolic syndrome. (Review) PMID: 16174284
49. This review focuses on the involvement of megalin during embryonic development and its interactions with the developmental morphogen sonic hedgehog. PMID: 16828734
50. Results show that the PPPSP motif and GSK3 activity are critical to allow megalin phosphorylation and also negatively regulate the receptor's recycling. PMID: 17555532
51. Study mapped Donnai-Barrow syndrome to chromosome 2q23.3-31.1 and identified LRP2 mutations in six families with Donnai-Barrow syndrome and one family with facio-oculo-acoustico-renal syndrome. PMID: 17632512
52. This review summarizes recent data on the biological function of megalin and focuses on its implication in embryonic nutrition and central nervous system malformations. PMID: 17979745
53. These results suggest that Dab2 is a ligand dependent bi-directional regulator of ERK1,2 activity. PMID: 18070591
54. confirm the association between LRP2 and levels of T-Cho and LDL-C in human plasma PMID: 18174661
55. light chain endocytosis is predominantly mediated by the megalin-cubilin tandem endocytic receptor and identify endocytosis as a key step in light chain cytotoxicity. PMID: 18448595
56. Polymorphisms within the megalin gene for associations with prostate cancer risk and outcomes. PMID: 18559602
57. Interaction of the A2 domain of F8 with LRP2 follows the general mode, requires dissociation of factor VIII from von Willebrand factor, and is activation sensitive. PMID: 18685438
58. results show different expression patterns of megalin and cubulin in calculous gallbladders and acalculous gallbladders suggesting an association with gallstone formation and implying a putative role of the two proteins in cholesterol endocytosis PMID: 18791690

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HGNC: 6694

OMIM: 222448

KEGG: hsa:4036

STRING: 9606.ENSP00000263816

UniGene: Hs.657729