Recombinant Human Melanocyte protein PMEL(PMEL),partial

Code CSB-YP021324HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P40967
Relevance Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP021324HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) PMEL.

  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP021324HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) PMEL.

Storage Buffer Tris-based buffer,50% glycerol
Alias ME20-M ;ME20MMelanocyte protein Pmel 17Melanocytes lineage-specific antigen GP100Melanoma-associated ME20 antigen;P1;P100Premelanosome protein;Silver locus protein homolog
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence KVPRNQDWLGVSRQLRTKAWNRQLYPEWTEAQRLDCWRGGQVSLKVSNDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNNTIINGSQVWGGQPVYPQETDDACIFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAMLGTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLTSCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVISTAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGMTPAEVSIVVLSGTTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGTATLRLV
Research Area Metabolism
Source Yeast
Gene Names PMEL
Protein Names Recommended name: Melanocyte protein PMELAlternative name(s): ME20-M Short name= ME20M Melanocyte protein Pmel 17 Melanocytes lineage-specific antigen GP100 Melanoma-associated ME20 antigen P1 P100 Premelanosome protein Si
Expression Region 25-467aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 49.0kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Subcellular Location Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus, Melanosome, Endosome, multivesicular body
Protein Families PMEL/NMB family
Tissue Specificity Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and
Database Links

HGNC: 10880

OMIM: 155550

KEGG: hsa:6490

STRING: 9606.ENSP00000402758

UniGene: Hs.95972

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