Recombinant Human Thyroid hormone receptor beta(THRB)

Code CSB-EP023514HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. P10828
Relevance Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.

  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.

Storage Buffer Tris-based buffer,50% glycerol
Alias Nuclear receptor subfamily 1 group A member 2c-erbA-2c-erbA-beta
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Research Area Cardiovascular
Source E.coli
Gene Names THRB
Protein Names Recommended name: Thyroid hormone receptor beta Alternative name(s): Nuclear receptor subfamily 1 group A member 2 c-erbA-2 c-erbA-beta
Expression Region 1-461aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 68.8kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Involvement in disease Generalized thyroid hormone resistance (GTHR); Generalized thyroid hormone resistance autosomal recessive (GTHRAR); Selective pituitary thyroid hormone resistance (PRTH)
Subcellular Location Nucleus
Protein Families Nuclear hormone receptor family, NR1 subfamily
Database Links

HGNC: 11799

OMIM: 145650

KEGG: hsa:7068

STRING: 9606.ENSP00000348827

UniGene: Hs.187861

Q&A and Customer Reviews

Q&A
Q:

Could you please indicate the concentration, purity and tag of cat# CSB-EP023514HU-50?

A:
Thanks for your inquiry. The concentration is determined during the production. The puirity is over 85%. The tag is N-terminal 6xHis-SUMO-tagged.
Customer Reviews

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