Recombinant Human Thyroid hormone receptor beta(THRB)

Code CSB-EP023514HU
Size US$1726
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.

  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.

Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names THRB
Uniprot No. P10828
Research Area Cardiovascular
Alternative Names Nuclear receptor subfamily 1 group A member 2c-erbA-2c-erbA-beta
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-461aa
Target Protein Sequence MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 68.8kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA Please contact us to get it.
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Citations

Disruptive effects of two organotin pesticides on the thyroid signaling pathway in Xenopus laevis during metamorphosis. Shuying Li, et al,Science of The Total Environment,2019

Applications: Binding assay
Species: Human
Review: Representative sensorgrams for kinetic analysis of hTRβ interactions. The T3 (A) was injected at concentrations of 0.0125, 0.025, 0.05 and 0.1 μM (from bottom to top).
PMID: 31476497

Q&A and Customer Reviews

 Q&A
Q:

Could you please indicate the concentration, purity and tag of cat# CSB-EP023514HU-50?

A:
Thanks for your inquiry. The concentration is determined during the production. The puirity is over 85%. The tag is N-terminal 6xHis-SUMO-tagged.
 Customer Reviews

Target Data

Function Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Involvement in disease Generalized thyroid hormone resistance (GTHR); Generalized thyroid hormone resistance autosomal recessive (GTHRAR); Selective pituitary thyroid hormone resistance (PRTH)
Subcellular Location Nucleus
Protein Families Nuclear hormone receptor family, NR1 subfamily
Database Links

HGNC: 11799

OMIM: 145650

KEGG: hsa:7068

STRING: 9606.ENSP00000348827

UniGene: Hs.187861

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