Recombinant Human Uncharacterized protein C1orf170 (C1orf170)

Code CSB-YP735955HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP735955HU
MSDS
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Source E.coli
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Code CSB-EP735955HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP735955HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP735955HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PERM1
Uniprot No.
Alternative Names
PERM1; C1orf170; PGC-1 and ERR-induced regulator in muscle protein 1; PPARGC1 and ESRR-induced regulator in muscle 1; Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1
Species
Homo sapiens (Human)
Expression Region
1-696
Target Protein Sequence
MPTQDGQLRR PARPPGPRAW MEPRGGGSSQ FSSCPGPASS GDQMQRLLQG PAPRPPGEPP GSPKSPGHST GSQRPPDSPG APPRSPSRKK RRAVGAKGGG HTGASASAQT GSPLLPAASP ETAKLMAKAG QEELGPGPAG APEPGPRSPV QEDRPGPGLG LSTPVPVTEQ GTDQIRTPRR AKLHTVSTTV WEALPDVSRA KSDMAVSTPA SEPQPDRDMA VSTPASEPQS DRDMAVSTPA SEPQPDTDMA VSTPASEPQP DRDMAVSIPA SKPQSDTAVS TPASEPQSSV ALSTPISKPQ LDTDVAVSTP ASKHGLDVAL PTAGPVAKLE VASSPPVSEA VPRMTESSGL VSTPVPRADA AGLAWPPTRR AGPDVVEMEA VVSEPSAGAP GCCSGAPALG LTQVPRKKKV RFSVAGPSPN KPGSGQASAR PSAPQTATGA HGGPGAWEAV AVGPRPHQPR ILKHLPRPPP SAVTRVGPGS SFAVTLPEAY EFFFCDTIEE NEEAEAAAAG QDPAGVQWPD MCEFFFPDVG AQRSRRRGSP EPLPRADPVP APIPGDPVPI SIPEVYEHFF FGEDRLEGVL GPAVPLPLQA LEPPRSASEG AGPGTPLKPA VVERLHLALR RAGELRGPVP SFAFSQNDMC LVFVAFATWA VRTSDPHTPD AWKTALLANV GTISAIRYFR RQVGQGRRSH SPSPSS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
Gene References into Functions
  1. Proteomics evidence was identified for the PERM1 gene PMID: 24870542
Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Muscle-specific expression is increased by endurance exercise.
Database Links

HGNC: 28208

OMIM: 615921

KEGG: hsa:84808

UniGene: Hs.271462

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