Recombinant Human Unconventional myosin-XV (MYO15A), partial

Code CSB-YP891537HU
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Source Yeast
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Code CSB-EP891537HU
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Source E.coli
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Code CSB-EP891537HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP891537HU
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Source Baculovirus
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Code CSB-MP891537HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
DFNB3; MYO15; MYO15_HUMAN; MYO15A; Myosin XV; Myosin XVA; Unconventional myosin 15; Unconventional myosin XV; Unconventional myosin-15; Unconventional myosin-XV
Homo sapiens (Human)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles.
Gene References into Functions
  1. Some recessive MYO15A variants can cause postlingual onset of progressive partial deafness. PMID: 29482514
  2. Study identified three novel mutations in MYO15A gene causing autosomal recessive nonsyndromic hearing loss in a Chinese family. PMID: 29849560
  3. Six novel MYO15 mutations were identified in a family with nonsyndromic hearing loss. PMID: 29692870
  4. MYO15A mutation was corrected by CRISPR/Cas9 system in the iPSCs and rescued the morphology and function of the derived hair cell-like cells. PMID: 26915297
  5. Study reports 14 novel recessive mutations in MYO15A that might be a deafness-causing mutations. Also, in the inner ear, myosin 15 seems to be necessary both for the development and the long-term maintenance of stereocilia. PMID: 27375115
  6. We identified in Moroccan deaf patients two mutations in PJVK and one mutation in MYO15A described for the first time in association with non-syndromic recessive hearing loss. PMID: 28964305
  7. The MYO15A variant is a common cause of hearing loss in a northeastern Brazilian town. PMID: 27870113
  8. Reconstruction of haplotype structure at MYO15A surrounding genomic regions indicated that the founder haplotype branched out in the past two to three centuries from a haplotype present worldwide. The MYO15A duplication emerges as the major cause of genetic hearing loss in Oman. PMID: 27734841
  9. novel homozygous donor splice site mutation, c.4596 + 1G > A (IVS12 + 1G > A) was found in MYO15A gene PMID: 28390610
  10. There are more than 39 deafness genes reported to cause non-syndromic hereditary hearing loss (HHL) in Iran, of which the most prevalent causative genes include GJB2, SLC26A4, MYO15A, and MYO7A. In addition, we highlight some of the more common genetic causes of syndromic HHL in Iran. [review] PMID: 27743438
  11. Mutations in exon 2 of MYO15A may cause a less severe phenotype, facilitating the rapid identification of mutations in exon 2 among the 66 exons when linkage of less severe hearing loss to DFNB3 is detected PMID: 26810297
  12. MYO15A mutations that affect domains other than the N-terminal domain, lead to profound sensorineural hearing loss throughout all frequencies. PMID: 26242193
  13. MYO15A Mutation is associated with Autosomal Recessive Nonsyndromic Hearing Loss. PMID: 26308726
  14. Mutations in the MYO15A gene are a notable cause of nonsyndromic hearing loss. PMID: 25792667
  15. Data indicate nine novel mutations in the genes encoding myosin VI, myosin VIIA and myosin XVA in hearing-impaired individuals from Israeli Jewish and Palestinian Arab families. PMID: 24105371
  16. MYO15A c.IVS25+3G>A and c.8375 T>C (p.V2792A) as the autosomal recessive hearing loss-causing mutations PMID: 24206587
  17. study found two novel compound heterozygous mutations of MYO15A and 13 nonsynonymous variants in the coding exons of MYO15A from Korean exomes in families with autosomal recessive nonsyndromic hearing loss PMID: 23865914
  18. sequencing of the MYO15A gene led to identification of 7 previously unreported mutations, including 4 missense mutations, 1 nonsense mutation, and 2 deletions in different regions of the myosin-XV protein PMID: 22736430
  19. the second exon of MYO15A from the DNA of all affected individuals ofHEARING LOSS IN A family revealed a duplication of Cytosine in a stretch of seven repetitive C nucleotides (c.1185dupC). PMID: 22245518
  20. Estimation of the prevalence of homozygous MYO15A mutations in autosomal recessive nonsyndromic deafness in Turkey as 0.062 (95% confidence interval is 0.020-0.105). PMID: 20642360
  21. myosin XVA protein and mRNA are widely distributed in endocrine cells of the gut and pancreas PMID: 12114748
  22. the large N-terminal extension of myosin XVA is required for hearing PMID: 17546645
  23. The motor head domain of the human myosin XVa protein suggests that the Gly1831Val mutation inhibits the powerstroke by reducing backbone flexibility and weakening the hydrophobic interactions necessary for signal transmission to the converter domain. PMID: 17853461
  24. These are the first MYO15A mutations reported to cause DFNB3 sensorineural hearing loss in the Iranian population. PMID: 19274735
  25. Sequencing of MYO15A identified two novel homozygous mutations: a nonsense (c.4998C>A (p.C1666X) in exon 17 and a splice site mutation in intron 54 (c.9229 + 1G>A). A novel mutation of unknown significance, c.7395 + 3G>C, was also identified. PMID: 19309289

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Involvement in disease
Deafness, autosomal recessive, 3 (DFNB3)
Subcellular Location
Cell projection, stereocilium. Cytoplasm, cytoskeleton.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Tissue Specificity
Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.
Database Links

HGNC: 7594

OMIM: 600316

KEGG: hsa:51168

STRING: 9606.ENSP00000205890

UniGene: Hs.462390

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