Recombinant Mouse Acid-sensing ion channel 1 (Asic1), partial

1. ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells. PMID: 30074209
2. These data demonstrate the involvement of an ASIC1a-mediated insular synaptic depression mechanism in extinction learning. PMID: 27924869
3. ASIC1a expression in astrocytes. Injection of rAAV-ASIC1a-shRNA into the dentate gyrus of the wide type TLE mouse model resulted in the inhibition of astrocytic ASIC1a expression and a reduction in spontaneous seizures PMID: 27526777
4. The findings of this study suggested a key role for ASIC1a in normal olfactory function. PMID: 28912013
5. Study suggests Acid-sensing ion channel 1a plays an inhibitory role in vasodilation in response to external protons, functional hyperemia, and exercise capacity. PMID: 28784852
6. Asic1 showed heightened mRNA expression, coherent with the repeated cross-fostering paradigm (RCF)-mice's respiratory hypersensitivity to CO2 and altered nociception. PMID: 27121911
7. Notch1 signaling may be required for ASIC1a-mediated neurite growth and neuronal differentiation in neuroblastoma cells. PMID: 28030818
8. The authors observed no preference for sodium at the "GAS belt" in the central constriction. Instead, they identified a band of glutamate and aspartate side chains at the lower end of the pore that enables preferential sodium conduction. PMID: 28498103
9. Asic1a KO mice exhibited prominent deficits in multiple fear-related behaviors. PMID: 28657172
10. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease PMID: 27820820
11. The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be PMID: 28159907
12. nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel 1a (ASIC1a) proteins. PMID: 28283476
13. ASIC1a is an important mediator of AHR. PMID: 27820848
14. Ca(2+) influx through ASIC1 mediates chronic hypoxia and ET-1-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 nuclear import. PMID: 27190058
15. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (mGlu) receptor-induced increase in action potential firing. PMID: 28137639
16. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi. PMID: 27402850
17. These results reveal new insights into the role of acid-sensing ion channels 1a in hippocampal synaptic plasticity and the underlying mechanisms PMID: 26996240
18. Studies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels. PMID: 27015804
19. differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b, was investigated. PMID: 26746198
20. This study demonstrated that asic1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels. PMID: 26924440
21. Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons PMID: 26174503
22. Deletion of the Asic1a gene significantly prevents RIP1 phosphorylation and brain damage, suggesting ASIC1a-mediated RIP1 activation has an important role in ischemic neuronal injury. PMID: 26523449
23. Study suggests that ASIC1a activity facilitates NMDAR function and exacerbates NMDAR-mediated neuronal death in pathological conditions PMID: 25947342
24. The data of this study suggest that ASIC1a may be a mediator of SCA1 pathogenesis and targeting ASIC1a could be a novel approach to treat SCA1. PMID: 24788087
25. ASIC1A inhibits neuronal plasticity underlying addiction-related behavior; disrupting ASIC1A in the mouse nucleus accumbens increases cocaine-conditioned place preference. PMID: 24952644
26. We conclude that this optogenetic method offers a minimally invasive approach that enables examining the biological consequences of ASIC1a currents in any structure of the CNS and in the modulation of animal behaviors. PMID: 24727474
27. Data suggest that mitochondrial ASIC1a may serve as an important regulator of MPT pores, which contributes to oxidative neuronal cell death. PMID: 23852371
28. Suggest that ASIC1a channels might be involved in controlling neuromuscular transmission, muscle contraction and fatigue in female mice. PMID: 24336653
29. Mutations in binding motifs of ASIC1a reduce surface expression and pH sensitivity; C-terminal motifs are important for ASIC1a trafficking and channel function. PMID: 23727453
30. ASIC1-/- mice exhibit blunted chronic hypoxia-induced pulmonary hypertension and diminished calcium entry. PMID: 24186095
31. ASIC1a plays an important role in the modulation of behavioral sensitivity to cocaine. PMID: 23644053
32. In summary, this study provides direct evidence for the presence of two distinct proton coordination sites in the extracellular region of ASIC1a, which jointly facilitate pore opening in response to extracellular acidification. PMID: 24142696
33. Our results indicated that in AsTg mice, the Ca(2)(+) response to the acid was facilitated in macrophages by a low threshold of ASIC1 and NCX1 molecules and the activity of these channel was possibly regulated by adiponectin. PMID: 24084100
34. Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. PMID: 22773952
35. The results of this study revealed the molecular mechanism of ASIC1a internalization and suggest the importance of endocytic pathway in functional regulation of ASIC1a channels as well as neuronal damages mediated by these channels. PMID: 23595764
36. the lower palm domain mediates conformational movements that drive pore opening and closing events in ASIC1a PMID: 23300086
37. Currents from ASIC1a(-/-) muscle afferents were less pH-sensitive and displayed faster recovery, currents from ASIC2(-/-) showed diminished potentiation by zinc, and currents from ASIC3(-/-) displayed slower desensitization than those from wild-type. PMID: 23109675
38. Anions modulate a variety of acid-sensing ion channel properties and are dependent on subunit composition. The mechanism of modulation for ASIC2a and -3 is distinct from that of ASIC1a. PMID: 23135698
39. ASIC1a has two desensitized states with markedly different stabilities. PMID: 23048040
40. Thus, our results reveal a novel mechanism underlying central sensitization and pain hypersensitivity, and reinforce the critical role of ASIC1a channels in these processes. PMID: 22553040
41. Our results indicate that ion selectivity is accomplished by the contribution of multiple sites in the pore of ASIC1a. PMID: 22371494
42. ASIC1a N366Q, which showed increased glycosylation and dendritic targeting, potentiated acidosis-induced spine loss. PMID: 22442073
43. correct folding of extracellular ectodomain plays a critical role in ASIC1a biogenesis and function PMID: 22046405
44. findings reveal a mechanism whereby snake venoms produce pain, and highlight an unexpected contribution of ASIC1 channels to nociception PMID: 22094702
45. GABA(A) receptors and glycine receptors modify ASICs in neurons through mechanisms that require the opening of chloride channels. PMID: 21789198
46. These data suggest that phenylketonuria-related brain injury is independent of ASIC1a expression PMID: 21663378
47. Insights into the mechanism of pore opening of acid-sensing ion channel 1a. PMID: 21388961
48. ASIC1, ASIC2, and ASIC3 are expressed in bone marrow-derived dendritic cells (DCs) at the mRNA and protein levels; extracellular acid can evoke ASIC-like currents in DCs. PMID: 21321108
49. this study suggested new neuroprotective strategies for stroke patients via inhibition of polyamine synthesis and subsequent spermine-ASIC interaction. PMID: 21307247
50. Results indicate that PICK1 regulates trafficking and function of ASIC1a in a lipid binding-dependent manner. PMID: 21176140

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KEGG: mmu:11419

STRING: 10090.ENSMUSP00000023758

UniGene: Mm.440107