Recombinant Mouse Acid-sensing ion channel 2 (Asic2), partial

1. ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells. PMID: 30074209
2. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi. PMID: 27402850
3. ASIC2 deletion significantly protected the mouse brain from ischemic damage in vivo. PMID: 26861816
4. Studies with ASIC1a-ASIC2a chimeras showed that swapping the thumb domain between subunits results in faster channel desensitization. Likewise, the covalent modification of Cys residues at selected positions in the beta-ball-thumb interface accelerates the desensitization of the mutant channels. PMID: 27015804
5. differential surface trafficking of ASIC1a, ASIC2a, and ASIC2b, was investigated. PMID: 26746198
6. These data identify the LL motifs as a negative regulator of ASIC2a trafficking and function, and suggest novel regulatory mechanisms in acid signaling. PMID: 26819004
7. ASIC2 contributes to transduction of the renal myogenic response and has a protective role against renal injury and hypertension. PMID: 25520010
8. These results lend support to an emerging role of ASIC2 in the targeting of ASICs to surface membranes, and allows for interaction with PSD-95 to regulate these processes. PMID: 24699665
9. A previously unknown postsynaptic current during neurotransmission mediated by ASIC1A and ASIC2 is well positioned to regulate synapse structure and function. PMID: 24952644
10. ASIC2 knockout mice showed less sensitization to challenge cocaine when compared to wild-type. PMID: 23644053
11. Currents from ASIC1a(-/-) muscle afferents were less pH-sensitive and displayed faster recovery, currents from ASIC2(-/-) showed diminished potentiation by zinc, and currents from ASIC3(-/-) displayed slower desensitization than those from wild-type. PMID: 23109675
12. Anions modulate a variety of acid-sensing ion channel properties and are dependent on subunit composition. The mechanism of modulation for ASIC2a and -3 is distinct from that of ASIC1a. PMID: 23135698
13. loss of ACCN1 function does not modify dental fluorosis severity in mice PMID: 22243220
14. Therefore, PICK1 interacts with BNaC/ASIC channels and may regulate their subcellular distribution or function in both peripheral and central neurons PMID: 11739374
15. These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons. PMID: 11854527
16. Photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a(ASIC2a) and ASIC2b; ASIC2 knock-out mice are more sensitive to light-induced retinal degeneration. PMID: 14762118
17. findings indicate that the absolute and relative amounts of ASIC subunits (ASIC1 & ASIC2) determine the amplitude and properties of hippocampal H(+)-gated currents and therefore may contribute to normal physiology and pathophysiology. PMID: 14960591
18. ASIC2b has a role in regulation of ASIC3 via the partner protein PICK-1 PMID: 14976185
19. results indicate that ASIC2 is not required for acid taste in mice, and that if a universal mammalian acid taste transduction mechanism exists, it likely uses other acid-sensitive receptors or ion channels PMID: 15102924
20. our data do not support a role of ASIC2 in cutaneous mechanosensation and visceral mechanonociception. PMID: 15169849
21. we report for the first time that serum- and glucocorticoid-inducible kinase-1 regulates transcription of ENaC subunits PMID: 15536167
22. ASIC2 is not directly involved in the mechanotransduction of the mammalian cochlea. ASIC2 contributes to suprathreshold functions of the cochlea. PMID: 15537887
23. In-situ hybridization studies showed that ASIC1b transcripts were expressed in the inner and outer hair cells.Immunohistochemical analyses revealed that the ASIC1b channels were located at the insertions of the stereocilia into the hair cells. PMID: 16951561
24. ASIC1, 2, and 3 are expressed preferentially in colonic neurons within thoracolumbar DRG. QPCR of whole thoracolumbar DRG revealed and abundance of ASIC2 > ASIC1 > ASIC3. PMID: 17177258
25. Acid sensing ion channels 2 are required for inhibition of visceral nociceptors by benzamil. PMID: 17467171
26. AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a, and calcineurin regulates ASIC1a and ASIC2a activity PMID: 17548344
27. Normal ASIC2 expression is required for normal pressure-induced constriction in the middle cerebral artery. PMID: 18296560
28. SGK1 and SGK1.1, driven by distinct promoters, any changes in SGK1 transcript level must be examined to define the isoform induced by each stimulus or neurological disorder PMID: 18334630
29. Following formalin injection, ASIC1(-/-) and ASIC2(-/-) mice showed enhanced pain behaviour PMID: 18801682
30. These data demonstrate that chronic cocaine exposure can upregulate ASIC expression in the striatum in a subunit-selective (ASIC1 and ASIC2) manner. PMID: 19427358
31. The results of this study indicate that ASIC2 facilitates ASIC1a localization and function in dendritic spines and suggest that the two subunits work in concert to regulate neuronal function. PMID: 19571134
32. ASIC2a and -3 are the major ASIC subunits in cardiac dorsal root ganglia neurons and provide potential molecular targets to attenuate chest pain and deleterious reflexes associated with cardiac disease. PMID: 19590043

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KEGG: mmu:11418

UniGene: Mm.234998