Recombinant Mouse Amiloride-sensitive sodium channel subunit beta (Scnn1b), partial

1. Scnn1b-Tg mice exhibited an approximately 50% reduction mucociliary clearance PMID: 28435155
2. Loss of betaENaC function resulted in meibomian gland disease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 MG disease and was sex dependent. PMID: 29107074
3. Nedd4-2-mediated ubiquitination of beta-ENaC leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport. PMID: 24093724
4. Our findings are consistent with the role of betaENaC as a vascular smooth muscle cell mechanosensor and function of evolutionarily related nematode degenerin proteins. PMID: 23552864
5. Cys substitutions at sites in the wrist domains of the beta and gamma subunits alter the Na+ self-inhibition response. PMID: 23144453
6. These findings demonstrate that myogenic constriction in afferent arterioles is dependent on normal expression of betaENaC PMID: 22419697
7. loss of beta-ENaC associated with early signs of renal injury and increased mean arterial pressure PMID: 21543417
8. generation of transgenic mice with airway-specific overexpression of the epithelial Na(+) channel (ENaC) is an alternative approach to mimic cystic fibrosis ion transport pathophysiology in the lung PMID: 21658636
9. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. PMID: 20566636
10. Il-6 activates ENaC-beta channels in cortical collecting duct cells. PMID: 20504903
11. Beta-ENaC is an important mediator of renal myogenic constriction-mediated renal blood flow autoregulation in vivo. PMID: 19889952
12. increase in whole cell current is attributed to a difference in the density of conducting channels with Liddle mutation in kidney PMID: 12684224
13. beta ENaC is a substrate for methylation in mouse cortical collecting duct cells PMID: 16469734
14. Mice heterozygous for beta-ENaC have a small but detectable defect in their ability to conserve Na+ and a more readily apparent defect in the ability to secrete K+. PMID: 16571596
15. beta and gammaENaC proteins are essential in mediating myogenic vasoconstriction in mouse renal interlobar arteries PMID: 16849693
16. Constitutive ENaC activation improved sodium-driven alveolar fluid clearance in the mouse lung, and attenuated the severity of hydrostatic pulmonary oedema. PMID: 17430990
17. both mouse and human mammary cells express all ENaC subunits, and they are regulated by steroid hormones in a temporal and cell-specific manner both in culture and in vivo PMID: 17510235
18. Epidermal growth factor inhibits sodium absorption via an ERK1/2-mediated down-regulation of Scnnb1. PMID: 17724164
19. Aldosterone-induced transcriptional up-regulation of the channel's beta- and gamma-subunit (beta ENaC and gamma ENaC) and of the serum- and glucocorticoid-inducible kinase 1 (SGK1) was similar in colon tissue from Liddle and wild-type animals. PMID: 18006588
20. despite the compensatory increase in alpha- and gamma-ENaC protein expression observed in mutant mouse lung, low expression of beta-ENaC results in a moderate impairment of baseline alveolar fluid clearance and in decreased AFC sensitivity to amiloride. PMID: 18024719
21. Amiloride administration did not have benefits if treatment was started after the development of CF-like lung disease in betaENaC-overexpressing mice. PMID: 18849497
22. There is a critical role of ENaC in the in vivo pathogenesis of cystic fibrosis (CF) lung disease and amiloride may be an effective preventive therapy for CF patients. PMID: 19060118
23. Middle cerebral artery pressure-induced constriction is inhibited in a mouse model of reduced betaENaC. PMID: 19553501

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KEGG: mmu:20277

STRING: 10090.ENSMUSP00000033161

UniGene: Mm.7709