Recombinant Mouse Anion exchange protein 2 (Slc4a2), partial

1. results strongly suggest that Ae2 is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 expression and fungal clearance is regulated. PMID: 27391897
2. Data indicate a key functional role of anion exchanger 2 (AE2) in the maintenance of the normal physiology of biliary epithelial cells (BEC) and the pathogenic consequences of reduced AE2 expression, including abnormal intrinsic characteristics of BEC and their production of signal molecules that lead to the chronic inflammatory responses in small bile ducts. PMID: 27592379
3. AE2 deficiency results in intrahepatic T-cell activation and PD-1/PD-L1 mediated deletion, favoring autoimmune cholangitis. PMID: 26396175
4. These findings demonstrate that CD8(+) T cells are critically dependent on Ae2 for pHi homeostasis and tuning of cell proliferation and activation. Ae2 thus constitutes a novel target to modulate CD8(+) T-cell responses. PMID: 24515893
5. Rescue of SLC4A2-deficient osteoclasts with functionally defined mutants of SLC4A2 indicates regulation of actin cytoskeletal reorganization by anion-exchange activity and intracellular pH, independent of SLC4A2's long N-terminal cytoplasmic domain. PMID: 23341620
6. expression of Slc4a2 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development. PMID: 20929715
7. AE2 is a component of the basolateral ion transport mechanisms that support anion secretion in the proximal colon. PMID: 20110461
8. GFP-tagged Ae2 localization depends upon MAPK activity PMID: 19823673
9. results are consistent with the hypothesis that AE2 mediates the major portion of the exchange across the basolateral membrane of mouse parotid and sublingual acinar cells PMID: 12958022
10. Male Ae2-/- mice are infertile, with an interruption of spermiogenesis. PMID: 14673081
11. AE2 is essential for gastric acid secretion and for normal development of secretory canalicular and tubulovesicular membranes in mouse parietal cells PMID: 15123620
12. importance to pH-dependent regulation of AE2 activity of the surrounding region of aa 312-578 PMID: 15452108
13. there are regulatory determinants in the AE2 N-terminal cytoplasmic domain of AE2c1 PMID: 16286476
14. Knockout mice, which suffer from severe hemolytic anemia and spherocytosis, display cardiac hypertrophy and impaired cardiac function. PMID: 17056673
15. contribution of nonconserved charged residues within the C-terminal transmembrane domain of AE2 to regulation by pH through mutation to the corresponding AE1 residues PMID: 17492309
16. Basolateral bicarbonate secretion via the anionic exchanger Ae2 is essential for mineral growth in the maturation stage enamel. PMID: 18042363
17. Mouse strain-specific coding polymorphism in the Slc4a2/Ae2 gene encodes Ae2c2 variants differing in isoform-specific dominant negative activity. PMID: 18192337
18. These results highlight the importance of bicarbonate transport via Ae2 in maintaining pH(i) homeostasis in cultured mouse fibroblasts. PMID: 18319251
19. AE2 is expressed at the apical membrane. Transcripts for AE2a were detected in RNA isolated from cultured ameloblast-like LS8 cells. AE2 is expressed in ameloblasts in vivo in a polarized fashion. PMID: 18362326
20. Ae2 deficiency alters pH(i) homeostasis in immunocytes and gene expression profile in cholangiocytes, leading to immunologic and hepatobiliary changes that resemble PBC. PMID: 18471521
21. data highlight SLC4A2 as a critical mediator of osteoclast differentiation and function in vitro and in vivo. PMID: 18971331
22. critical segments of RL1 constitute part of an AE2 pH sensor that, together with residues within the N-terminal half of the TMD, constrain the AE2 polypeptide in a conformation required for regulation of anion exchange by pHi. PMID: 19103596
23. Severe osteopetrosis was encountered in Ae2 knockout (Ae2-/-) mice where the skeletal development was impaired with a higher diffuse radio-density on x-ray examination and the bone marrow cavity was occupied by irregular bone speculae PMID: 19164575
24. In contrast to the abnormalities observed in the long bones, the skull of Ae2(a,b)(-/-) mice showed no alterations, indicating that calvaria osteoclasts may display normal resorptive activity. PMID: 19564250

Show More

Hide All

KEGG: mmu:20535

STRING: 10090.ENSMUSP00000078972

UniGene: Mm.4580