Recombinant Mouse C->U-editing enzyme APOBEC-1 (Apobec1)

1. APOBEC1-mediated RNA editing occurs within brain microglia cells and is key to maintaining their resting status. Apobec1-/- mice display age-related signs of CNS neurodegeneration. PMID: 29167375
2. Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners. PMID: 27582469
3. substantial rearrangement/duplication of transgene elements is present, and transgene integration was accompanied by the deletion of a 19,500 bp fragment of genomic DNA that contains the promoter, exon 1 and part of intron 1 of the APOBEC1 complementation factor (A1cf) gene, as well as several elements that are predicted to regulate chromosomal architecture PMID: 27165291
4. The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney. PMID: 28069890
5. Apobec-1-dependent C-to-U RNA editing exerts broad functional effects in a tissue-specific manner. PMID: 24946870
6. RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing. PMID: 24916387
7. In contrast to in vitro results, APOBEC1 neither inhibited nor significantly drove the molecular evolution of Friend retrovirus in wild type or APOBEC1 knockout mice. PMID: 25303118
8. Individual genetic variability at the Apobec1 locus results in differential rates of C-to-U(T) editing in murine macrophages; with mouse strains expressing mostly a truncated alternative transcript isoform of Apobec1 exhibiting lower rates of editing. PMID: 24249727
9. The transgenic rescue of intestinal apobec-1 expression restores C-to-U RNA editing of apoB mRNA in vivo, including the canonical site at position 6666 and also at approximately 20 other newly identified downstream sites present in WT mice. PMID: 22993231
10. Results suggest that apo B mRNA editing protein (Apobec1 cytidine deaminase) plays a central role in controlling testicular germ cell tumors susceptibility in both a conventional and a transgenerational manner. PMID: 22923694
11. The transcriptomics approach to RNA editing presented in this study dramatically expands the list of APOBEC1 mRNA editing targets and reveals a novel cellular mechanism for the modification of transcript 3' UTRs. PMID: 21258325
12. LDL receptor and the apolipoprotein B mRNA editing enzyme Apobec1 are regulated via calcium signaling in mechanistic response to genetic, mechanical, and environmental insults that trigger an imbalance of intracellular calcium homeostasis PMID: 20667539
13. studies establish the existence of preferential degradation of intestinal apolipoprotein B-100 and subtle defects in triglyceride secretion in apolipoprotein B editing complex 1-/- mice PMID: 12816761
14. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling PMID: 12896982
15. apobec-1-mediated apoB mRNA editing is regulated by BAG-4 PMID: 14559896
16. RNA editing of this protein is unable to induce somatic hypermutation in mammalian cells. PMID: 14559972
17. Lipopolysaccharide increases intestinal stem cell survival through apobec-1-mediated regulation of cyclooxygenase-2 messenger RNA stability. PMID: 15480992
18. Deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation. PMID: 17875695
19. Murine APOBEC1 is a hypermutator of both RNA and single-stranded DNA in vivo, which could exert occasional side effects upon overexpression. PMID: 18983852
20. the AU-rich RNA binding-protein Apobec-1 mediates post-transcriptional regulation of Cyp7a1 expression and influences susceptibility to diet-induced gallstone formation PMID: 19386592

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KEGG: mmu:11810

STRING: 10090.ENSMUSP00000108204

UniGene: Mm.3333