Recombinant Mouse COUP transcription factor 2 (Nr2f2)

1. We showed that the orphan receptor COUP-TFII is an important player in hepatic neoangiogenesis. COUP-TFII expression in hepatic stellate cells (HSC) controls the crosstalk between hepatic HSC and endothelial cells coordinating vascular remodelling during liver injury. PMID: 27866920
2. elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance. PMID: 28818950
3. Together, these results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII. PMID: 28005008
4. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons PMID: 28694260
5. A regulatory role of COUP-TFII in the development of muscular dystrophy. PMID: 27617862
6. FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation PMID: 27404388
7. results identify a novel cooperation between MEF2 factors and NR2F2 in the expression of the Akr1c14 gene PMID: 26748576
8. These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch signaling target gene Hey1. PMID: 26719988
9. Myocardial Nr2f2 overexpression causes heart failure. Nr2f2 represses genes critical for mitochondrial ETC enzyme activity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased ROS and lower rates of oxygen consumption. PMID: 26356605
10. Data show that Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2) and its down-regulation control the destination of preoptic area (POa)-derived GABAergic neurons. PMID: 26305926
11. These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival. PMID: 25372459
12. COUP-TFII cooperates with the nuclear receptor steroidogenic factor 1 (SF1) to further enhance Insl3 promoter activity in Leydig cells. PMID: 24780841
13. Postnatal increase in hepatic COUP-TFII gene expression is involved in the regulation of liver fatty acid oxidation, which in turn sustains an active hepatic gluconeogenesis essential to maintain blood glucose level required for newborn mice survival. PMID: 25783893
14. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. PMID: 25922524
15. MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression. PMID: 25412310
16. miR-302a is induced by osteogenic stimuli and promotes osteoblast differentiation by targeting Chicken ovalbumin upstream promoter transcription factor II PMID: 25215426
17. These data identify an essential role for the nuclear receptor NR2F2 as a direct activator of Star gene expression in Leydig cells, and thus in the control of steroid hormone biosynthesis. PMID: 24899578
18. Critical function of proinflammatory cytokines and the COUP-TFII regulatory gene network in the progression of endometriosis. PMID: 24423359
19. Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII. PMID: 24058409
20. COUP-TFII and related NRs such as the COUPTFs and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene. PMID: 23975195
21. Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires a F/YSXXLXXL/Y motif. NSD1 interaction with liganded NRs is mediated by an overlapping LXXLL motif. PMID: 23975195
22. COUP-TFII promotes atrial genes while suppressing ventricular gene expression. PMID: 23725765
23. COUP-TF II interacts physically with AR in vitro and in vivo. PMID: 23145053
24. earlier-born dMGE-derived COUP-TFII+ interneurons occupy cortical layer V, later-born caudal ganglionic eminences-derived COUP-TFII+ ones preferentially occupy superficial cortical layers PMID: 22791192
25. COUP-TFII expression levels in the ventromedial nucleus are keys in the ability to resist the onset of hypoglycemia-associated autonomic failure. PMID: 23440210
26. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. PMID: 23406903
27. findings reveal that the destruction of the TGF-beta-dependent barrier by COUP-TFII is crucial for the progression of PTEN-mutant prostate cancer into a life-threatening disease PMID: 23201680
28. COUP-TFII plays cell-autonomous roles in the endocardium and the epicardium for endocardial and epicardial EMT, which are required for proper valve and coronary vessel formation during heart development. PMID: 22962329
29. Data show that COUP-TFII is involved in the control of renin gene expression. PMID: 22645148
30. COUP-TFII negatively regulates osteoblast differentiation via interaction with Runx2, and during the differentiation state, BMP2-induced Runx2 represses COUP-TFII expression and promotes osteoblast differentiation. PMID: 22493443
31. The results showed, for the first time, that COUP-TFII plays a central role in the specification of metanephric fate and in the maintenance of metanephric mesenchyme proliferation and survival by acting as a crucial regulator of Eya1 and Wt1 expression. PMID: 22669823
32. It was concluded that both Nr2f2 and Nr2f6 negatively regulate renin promoter activity, but may do so by divergent mechanisms. PMID: 22278040
33. COUP-TFII is a novel component of the GLP-1 signaling cascade that increases beta-cell number during the neonatal period. PMID: 22292058
34. COUP-TFII controls amygdala patterning by regulating neuropilin expression. PMID: 22492355
35. COUP-TFII directs the plasticity of mesenchymal precursors primarily through the combined modulation of Wnt signaling, Runx2 activity, as well as PPARgamma and Sox9 expression. PMID: 21873211
36. COUP-TFII regulates several nuclear hormone receptors, and critical metabolic and muscle specific genes. PMID: 21119012
37. LHbeta promoter activity is further regulated by the orphan nuclear receptors, chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and COUP-TFII). PMID: 20797425
38. hypothalamic COUP-TFII gene expression could be a central integrator of insulin and melanocortin signaling pathway within the ventromedial hypothalamus PMID: 20976162
39. Overexpression of COUP-TFII is associated with pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling. PMID: 20978203
40. The results demonstrate that during the periimplantation period, COUP-TFII regulates embryo attachment and decidualization through controlling ER activity. COUP-TFII expression is still required in the postimplantation period to facilitate placentation. PMID: 20219888
41. neuropilin-2 transcriptional regulation by COUP-TFII modulates multiple steps in murine lymphatic vessel development PMID: 20364082
42. the nuclear hormone receptor Coup-TFII is necessary for the activation of Prox1 in embryonic veins by directly binding a conserved DNA domain in the regulatory region of Prox1 PMID: 20360386
43. COUP-TFII is a major angiogenesis regulator within the tumor microenvironment. PMID: 20133706
44. These results suggested that endoglin plays distinct and cell-autonomous roles in vSMC recruitment and arteriovenous specification via COUPTFII in angiogenesis that may contribute to hereditary hemorrhagic telangiectasia. PMID: 19705428
45. we found that COUP-TFI and -TFII play roles in amacrine cell differentiation, and COUP-TFgamma has distinct expression pattern and roles during retinal development. PMID: 19766631
46. tissue distribution of COUP-TFII in developing mouse tissues PMID: 12385758
47. COUP-TFII represses the alpha-subunit of mitochondrial F1F0 ATP synthase (ATPA) complex and inhibits the USF2-dependent transactivation of the ATPA promoter through competition for an overlapping bindng site in the ATPA cis-acting regulatory element 1. PMID: 12614160
48. COUP-TFII is required for limb and skeletal muscle development. PMID: 15572686
49. COUP-TFII is a new, important regulator of glucose homeostasis and insulin sensitivity. PMID: 15855320
50. COUP-TFII has a critical role in repressing Notch signalling to maintain vein identity, which suggests that vein identity is under genetic control and is not derived by a default pathway PMID: 15875024

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KEGG: mmu:11819

STRING: 10090.ENSMUSP00000032768

UniGene: Mm.158143