Recombinant Mouse Canalicular multispecific organic anion transporter 1 (Abcc2), partial

1. The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity. PMID: 29976647
2. Circadian oscillation of Mrp2 protein expression was clearly observed in the mouse liver with levels down at the light phase and up at the dark phase. PMID: 28479363
3. Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog. PMID: 24641901
4. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice. PMID: 24334255
5. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells. PMID: 22914987
6. hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis PMID: 23125159
7. Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX. PMID: 21841039
8. hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation. PMID: 22057277
9. Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan PMID: 21674030
10. In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism. PMID: 21451505
11. Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic. PMID: 20584751
12. NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow PMID: 20404332
13. Mrp2 mediates the adenosine triphosphate-dependent transport of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine but not S-(1,2-dichlorovinyl)-l-cysteine (DCVC) and may be involved in renal secretion of Ac-DCVC. PMID: 20060011
14. Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX. PMID: 19996279
15. Mrp2 transcription is down-regulated by Y-box protein 1. PMID: 12963034
16. mutation in the canalicular mdr2 is an important factor during the development of progressive familial cholestasis PMID: 12967592
17. nuclear factor, erythroid derived 2, like 2 appears to regulate Mrp2 gene expression via an antioxidant-response element element located at the proximal region of its promoter in response to exposure to xenobiotics PMID: 16426233
18. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 are reviewed. PMID: 17273943
19. Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo. PMID: 17485564
20. This decrease was not due to reduced cellular DMP uptake, as shown by normal expression of Oatp1b2 in livers of TR(-) rats and functional DMP uptake into isolated TR(-) rat hepatocytes. PMID: 17707334
21. There are important species differences in the transport efficiency of MRP2 substrates and in the modulation of transport by other compounds that should be taken into account, when results obtained in mice are extrapolated to humans. PMID: 18180270
22. Like Mrp2, GSTpi protein expression increased with pregnane X receptor activation PMID: 18349876
23. Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3. PMID: 19017997
24. Abcc2 is important for (biliary) excretion of MTX and its toxic metabolite 7OH-MTX. PMID: 19088030
25. membrane cholesterol content is a critical determinant of ABCB11/ABCC2 transport activity, which might provide an explanation for the etiology of ATP8B1 disease PMID: 19228692
26. Complex pharmacokinetic behavior of ezetimibe depends on intestinal abcc2, abcc3, and abcg2. PMID: 19443695

Show More

Hide All

KEGG: mmu:12780

STRING: 10090.ENSMUSP00000026208

UniGene: Mm.39054